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Gene: CSNK2A1 |
Gene summary for CSNK2A1 |
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Gene information | Species | Human | Gene symbol | CSNK2A1 | Gene ID | 1457 |
Gene name | casein kinase 2 alpha 1 | |
Gene Alias | CK2A1 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | P68400 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1457 | CSNK2A1 | GSM4909292 | Human | Breast | IDC | 4.51e-05 | 5.92e-01 | 0.1236 |
1457 | CSNK2A1 | GSM4909293 | Human | Breast | IDC | 4.40e-25 | 6.13e-01 | 0.1581 |
1457 | CSNK2A1 | GSM4909296 | Human | Breast | IDC | 1.70e-04 | -1.01e-01 | 0.1524 |
1457 | CSNK2A1 | GSM4909297 | Human | Breast | IDC | 6.24e-04 | -7.29e-02 | 0.1517 |
1457 | CSNK2A1 | GSM4909298 | Human | Breast | IDC | 1.95e-02 | 2.13e-01 | 0.1551 |
1457 | CSNK2A1 | GSM4909311 | Human | Breast | IDC | 1.33e-18 | -9.43e-02 | 0.1534 |
1457 | CSNK2A1 | GSM4909312 | Human | Breast | IDC | 5.15e-08 | 9.35e-02 | 0.1552 |
1457 | CSNK2A1 | GSM4909317 | Human | Breast | IDC | 7.08e-06 | 4.04e-01 | 0.1355 |
1457 | CSNK2A1 | GSM4909319 | Human | Breast | IDC | 6.61e-18 | -1.95e-01 | 0.1563 |
1457 | CSNK2A1 | GSM4909320 | Human | Breast | IDC | 2.00e-05 | -2.10e-02 | 0.1575 |
1457 | CSNK2A1 | GSM4909321 | Human | Breast | IDC | 4.32e-09 | -1.27e-01 | 0.1559 |
1457 | CSNK2A1 | ctrl6 | Human | Breast | Precancer | 2.48e-02 | 3.24e-01 | -0.0061 |
1457 | CSNK2A1 | M2 | Human | Breast | IDC | 4.29e-02 | 3.39e-01 | 0.21 |
1457 | CSNK2A1 | P1 | Human | Breast | IDC | 2.83e-09 | 8.31e-02 | 0.1527 |
1457 | CSNK2A1 | DCIS2 | Human | Breast | DCIS | 6.46e-55 | 1.62e-01 | 0.0085 |
1457 | CSNK2A1 | CA_HPV_3 | Human | Cervix | CC | 7.54e-05 | 1.41e-02 | 0.0414 |
1457 | CSNK2A1 | CCI_2 | Human | Cervix | CC | 3.21e-03 | 5.26e-01 | 0.5249 |
1457 | CSNK2A1 | CCI_3 | Human | Cervix | CC | 5.26e-04 | 5.16e-01 | 0.516 |
1457 | CSNK2A1 | sample3 | Human | Cervix | CC | 4.64e-05 | 1.20e-01 | 0.1387 |
1457 | CSNK2A1 | T3 | Human | Cervix | CC | 2.84e-03 | 1.30e-01 | 0.1389 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003133027 | Skin | AK | negative regulation of cellular catabolic process | 61/1910 | 262/18723 | 4.95e-10 | 5.42e-08 | 61 |
GO:001604920 | Skin | AK | cell growth | 93/1910 | 482/18723 | 9.55e-10 | 9.42e-08 | 93 |
GO:000989627 | Skin | AK | positive regulation of catabolic process | 94/1910 | 492/18723 | 1.32e-09 | 1.26e-07 | 94 |
GO:000989526 | Skin | AK | negative regulation of catabolic process | 68/1910 | 320/18723 | 3.17e-09 | 2.65e-07 | 68 |
GO:005254727 | Skin | AK | regulation of peptidase activity | 88/1910 | 461/18723 | 4.65e-09 | 3.44e-07 | 88 |
GO:004586127 | Skin | AK | negative regulation of proteolysis | 72/1910 | 351/18723 | 5.40e-09 | 3.90e-07 | 72 |
GO:005254827 | Skin | AK | regulation of endopeptidase activity | 82/1910 | 432/18723 | 2.03e-08 | 1.18e-06 | 82 |
GO:004217724 | Skin | AK | negative regulation of protein catabolic process | 33/1910 | 121/18723 | 9.33e-08 | 4.25e-06 | 33 |
GO:003017717 | Skin | AK | positive regulation of Wnt signaling pathway | 35/1910 | 140/18723 | 3.93e-07 | 1.48e-05 | 35 |
GO:200005925 | Skin | AK | negative regulation of ubiquitin-dependent protein catabolic process | 18/1910 | 48/18723 | 4.80e-07 | 1.74e-05 | 18 |
GO:190305120 | Skin | AK | negative regulation of proteolysis involved in cellular protein catabolic process | 21/1910 | 64/18723 | 7.37e-07 | 2.49e-05 | 21 |
GO:190336320 | Skin | AK | negative regulation of cellular protein catabolic process | 23/1910 | 75/18723 | 8.63e-07 | 2.82e-05 | 23 |
GO:200011627 | Skin | AK | regulation of cysteine-type endopeptidase activity | 48/1910 | 235/18723 | 2.09e-06 | 6.01e-05 | 48 |
GO:000155820 | Skin | AK | regulation of cell growth | 73/1910 | 414/18723 | 2.21e-06 | 6.27e-05 | 73 |
GO:004328127 | Skin | AK | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 44/1910 | 209/18723 | 2.38e-06 | 6.65e-05 | 44 |
GO:000645726 | Skin | AK | protein folding | 44/1910 | 212/18723 | 3.54e-06 | 8.91e-05 | 44 |
GO:001046625 | Skin | AK | negative regulation of peptidase activity | 51/1910 | 262/18723 | 4.43e-06 | 1.07e-04 | 51 |
GO:005134626 | Skin | AK | negative regulation of hydrolase activity | 67/1910 | 379/18723 | 5.22e-06 | 1.21e-04 | 67 |
GO:006107725 | Skin | AK | chaperone-mediated protein folding | 20/1910 | 67/18723 | 6.97e-06 | 1.55e-04 | 20 |
GO:001095120 | Skin | AK | negative regulation of endopeptidase activity | 49/1910 | 252/18723 | 6.98e-06 | 1.55e-04 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0413716 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0452018 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0413717 | Breast | Precancer | Mitophagy - animal | 15/684 | 72/8465 | 5.22e-04 | 3.93e-03 | 3.01e-03 | 15 |
hsa0452019 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0502023 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0501023 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0502223 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0413723 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0502033 | Breast | IDC | Prion disease | 102/867 | 273/8465 | 3.70e-34 | 4.01e-32 | 3.00e-32 | 102 |
hsa0501033 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0502233 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0413733 | Breast | IDC | Mitophagy - animal | 17/867 | 72/8465 | 7.61e-04 | 6.04e-03 | 4.52e-03 | 17 |
hsa0502043 | Breast | DCIS | Prion disease | 100/846 | 273/8465 | 1.44e-33 | 1.55e-31 | 1.14e-31 | 100 |
hsa0501043 | Breast | DCIS | Alzheimer disease | 105/846 | 384/8465 | 3.23e-23 | 1.49e-21 | 1.10e-21 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CSNK2A1 | SNV | Missense_Mutation | rs61730061 | c.398T>C | p.Ile133Thr | p.I133T | P68400 | protein_coding | deleterious(0.02) | probably_damaging(0.937) | TCGA-AN-A0XP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CSNK2A1 | SNV | Missense_Mutation | c.228N>T | p.Lys76Asn | p.K76N | P68400 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
CSNK2A1 | SNV | Missense_Mutation | c.785N>G | p.Asn262Ser | p.N262S | P68400 | protein_coding | tolerated(0.13) | benign(0.006) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CSNK2A1 | SNV | Missense_Mutation | novel | c.134N>C | p.Leu45Ser | p.L45S | P68400 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CSNK2A1 | SNV | Missense_Mutation | c.989N>T | p.Asp330Val | p.D330V | P68400 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-AA-3489-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CSNK2A1 | SNV | Missense_Mutation | c.1154N>A | p.Ala385Asp | p.A385D | P68400 | protein_coding | deleterious_low_confidence(0) | benign(0.056) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CSNK2A1 | SNV | Missense_Mutation | c.811N>T | p.Asp271Tyr | p.D271Y | P68400 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CSNK2A1 | SNV | Missense_Mutation | c.420T>G | p.Ile140Met | p.I140M | P68400 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CSNK2A1 | SNV | Missense_Mutation | c.833G>A | p.Arg278Gln | p.R278Q | P68400 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CSNK2A1 | SNV | Missense_Mutation | c.848N>A | p.Arg283His | p.R283H | P68400 | protein_coding | tolerated(0.06) | possibly_damaging(0.877) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | inhibitor | 249565806 | SILMITASERTIB | |
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | CX-4945 | SILMITASERTIB | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | TAMATINIB | R-406 | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | inhibitor | 249565820 | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | AZAKENPAULLONE | AZAKENPAULLONE | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | HEPARIN | HEPARIN | 7794926 | |
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | MLN-8054 | MLN-8054 | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | SP-600125 | SP-600125 | ||
1457 | CSNK2A1 | KINASE, TRANSCRIPTION FACTOR, ENZYME, DRUGGABLE GENOME, SERINE THREONINE KINASE, TUMOR SUPPRESSOR | CYC-116 | CYC-116 |
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