GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016493 | Colorectum | FAP | osteoblast differentiation | 51/2622 | 229/18723 | 4.40e-04 | 5.22e-03 | 51 |
GO:00601473 | Colorectum | FAP | regulation of posttranscriptional gene silencing | 17/2622 | 52/18723 | 4.84e-04 | 5.59e-03 | 17 |
GO:00507924 | Colorectum | FAP | regulation of viral process | 39/2622 | 164/18723 | 5.21e-04 | 5.91e-03 | 39 |
GO:00609662 | Colorectum | FAP | regulation of gene silencing by RNA | 17/2622 | 53/18723 | 6.20e-04 | 6.82e-03 | 17 |
GO:00022441 | Colorectum | FAP | hematopoietic progenitor cell differentiation | 29/2622 | 114/18723 | 8.35e-04 | 8.71e-03 | 29 |
GO:19039004 | Colorectum | FAP | regulation of viral life cycle | 35/2622 | 148/18723 | 1.09e-03 | 1.05e-02 | 35 |
GO:00450693 | Colorectum | FAP | regulation of viral genome replication | 23/2622 | 85/18723 | 1.14e-03 | 1.09e-02 | 23 |
GO:00508071 | Colorectum | FAP | regulation of synapse organization | 46/2622 | 211/18723 | 1.30e-03 | 1.20e-02 | 46 |
GO:00609971 | Colorectum | FAP | dendritic spine morphogenesis | 18/2622 | 61/18723 | 1.30e-03 | 1.20e-02 | 18 |
GO:0017015 | Colorectum | FAP | regulation of transforming growth factor beta receptor signaling pathway | 31/2622 | 128/18723 | 1.35e-03 | 1.24e-02 | 31 |
GO:00015033 | Colorectum | FAP | ossification | 79/2622 | 408/18723 | 1.53e-03 | 1.37e-02 | 79 |
GO:00990722 | Colorectum | FAP | regulation of postsynaptic membrane neurotransmitter receptor levels | 18/2622 | 62/18723 | 1.60e-03 | 1.42e-02 | 18 |
GO:00071621 | Colorectum | FAP | negative regulation of cell adhesion | 61/2622 | 303/18723 | 1.96e-03 | 1.65e-02 | 61 |
GO:1903844 | Colorectum | FAP | regulation of cellular response to transforming growth factor beta stimulus | 31/2622 | 131/18723 | 2.01e-03 | 1.67e-02 | 31 |
GO:00072191 | Colorectum | FAP | Notch signaling pathway | 38/2622 | 172/18723 | 2.56e-03 | 2.01e-02 | 38 |
GO:0050803 | Colorectum | FAP | regulation of synapse structure or activity | 46/2622 | 218/18723 | 2.59e-03 | 2.03e-02 | 46 |
GO:0060216 | Colorectum | FAP | definitive hemopoiesis | 8/2622 | 19/18723 | 2.61e-03 | 2.03e-02 | 8 |
GO:0090092 | Colorectum | FAP | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 52/2622 | 256/18723 | 3.33e-03 | 2.44e-02 | 52 |
GO:0060428 | Colorectum | FAP | lung epithelium development | 12/2622 | 37/18723 | 3.43e-03 | 2.48e-02 | 12 |
GO:0030323 | Colorectum | FAP | respiratory tube development | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADA | SNV | Missense_Mutation | | c.217N>A | p.Ala73Thr | p.A73T | P00813 | protein_coding | deleterious(0.01) | benign(0.386) | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
ADA | SNV | Missense_Mutation | rs748974674 | c.935N>G | p.Lys312Arg | p.K312R | P00813 | protein_coding | tolerated(0.15) | benign(0.007) | TCGA-A8-A08O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | PD |
ADA | SNV | Missense_Mutation | rs121908721 | c.872N>T | p.Ser291Leu | p.S291L | P00813 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A1HE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADA | insertion | Frame_Shift_Ins | novel | c.1006_1007insTGGGTACTACAAGTTG | p.Pro336LeufsTer9 | p.P336Lfs*9 | P00813 | protein_coding | | | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
ADA | insertion | Frame_Shift_Ins | novel | c.946_947insT | p.Gly316ValfsTer4 | p.G316Vfs*4 | P00813 | protein_coding | | | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | | SD |
ADA | insertion | Nonsense_Mutation | novel | c.944_945insCCCAGGCTGAATAAGTCCATTCCTGCACGTGTCTGCGA | p.Met315IlefsTer4 | p.M315Ifs*4 | P00813 | protein_coding | | | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | | SD |
ADA | SNV | Missense_Mutation | | c.347C>T | p.Pro116Leu | p.P116L | P00813 | protein_coding | deleterious(0.01) | possibly_damaging(0.614) | TCGA-EX-A69L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ADA | SNV | Missense_Mutation | novel | c.340N>A | p.Pro114Thr | p.P114T | P00813 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-ZJ-AAX4-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ADA | SNV | Missense_Mutation | | c.824N>G | p.Asp275Gly | p.D275G | P00813 | protein_coding | tolerated(0.15) | benign(0.045) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADA | SNV | Missense_Mutation | | c.754N>A | p.Leu252Met | p.L252M | P00813 | protein_coding | deleterious(0.05) | probably_damaging(0.987) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | 2,3-DIDEOXYADENOSINE | | 3496090 |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | PENTOSTATIN | PENTOSTATIN | |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | DIPYRIDAMOLE | DIPYRIDAMOLE | |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | inhibitor | 178101507 | PENTOSTATIN | |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | 6-METHYLMERCAPTOPURINE RIBOSIDE | | 10102 |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy | | |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | HYDROCORTISONE | HYDROCORTISONE | 2395837 |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | Pentostatin | PENTOSTATIN | |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | CORDYCEPIN | CORDYCEPIN | 24283924 |
100 | ADA | DRUGGABLE GENOME, ENZYME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | | COBALT | | 9144774 |