![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TXNIP |
Gene summary for TXNIP |
![]() |
Gene information | Species | Human | Gene symbol | TXNIP | Gene ID | 10628 |
Gene name | thioredoxin interacting protein | |
Gene Alias | ARRDC6 | |
Cytomap | 1q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9H3M7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10628 | TXNIP | GSM4909285 | Human | Breast | IDC | 3.46e-09 | 3.59e-01 | 0.21 |
10628 | TXNIP | GSM4909286 | Human | Breast | IDC | 7.78e-06 | -1.45e-01 | 0.1081 |
10628 | TXNIP | GSM4909290 | Human | Breast | IDC | 6.47e-07 | -4.54e-01 | 0.2096 |
10628 | TXNIP | GSM4909294 | Human | Breast | IDC | 1.29e-02 | 2.07e-01 | 0.2022 |
10628 | TXNIP | GSM4909296 | Human | Breast | IDC | 8.46e-10 | -3.99e-01 | 0.1524 |
10628 | TXNIP | GSM4909297 | Human | Breast | IDC | 7.38e-06 | -4.16e-02 | 0.1517 |
10628 | TXNIP | GSM4909298 | Human | Breast | IDC | 3.62e-61 | 9.82e-01 | 0.1551 |
10628 | TXNIP | GSM4909303 | Human | Breast | IDC | 1.80e-11 | 7.60e-01 | 0.0438 |
10628 | TXNIP | GSM4909304 | Human | Breast | IDC | 4.28e-12 | -4.67e-01 | 0.1636 |
10628 | TXNIP | GSM4909305 | Human | Breast | IDC | 6.61e-04 | 3.68e-01 | 0.0436 |
10628 | TXNIP | GSM4909308 | Human | Breast | IDC | 5.37e-04 | -3.75e-01 | 0.158 |
10628 | TXNIP | GSM4909311 | Human | Breast | IDC | 7.30e-19 | -3.61e-01 | 0.1534 |
10628 | TXNIP | GSM4909317 | Human | Breast | IDC | 5.79e-31 | 8.18e-01 | 0.1355 |
10628 | TXNIP | GSM4909318 | Human | Breast | IDC | 1.08e-02 | 4.91e-01 | 0.2031 |
10628 | TXNIP | GSM4909319 | Human | Breast | IDC | 1.16e-23 | -5.25e-01 | 0.1563 |
10628 | TXNIP | GSM4909321 | Human | Breast | IDC | 5.34e-23 | -5.24e-01 | 0.1559 |
10628 | TXNIP | brca10 | Human | Breast | Precancer | 3.00e-05 | -4.04e-01 | -0.0029 |
10628 | TXNIP | M1 | Human | Breast | IDC | 8.97e-13 | 5.66e-01 | 0.1577 |
10628 | TXNIP | NCCBC11 | Human | Breast | DCIS | 5.79e-07 | 6.32e-01 | 0.1232 |
10628 | TXNIP | NCCBC14 | Human | Breast | DCIS | 3.13e-06 | -1.18e-01 | 0.2021 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004254228 | Thyroid | HT | response to hydrogen peroxide | 32/1272 | 146/18723 | 2.66e-09 | 2.64e-07 | 32 |
GO:004854530 | Thyroid | HT | response to steroid hormone | 54/1272 | 339/18723 | 3.80e-09 | 3.52e-07 | 54 |
GO:007259428 | Thyroid | HT | establishment of protein localization to organelle | 60/1272 | 422/18723 | 4.06e-08 | 2.69e-06 | 60 |
GO:003450420 | Thyroid | HT | protein localization to nucleus | 42/1272 | 290/18723 | 2.68e-06 | 9.37e-05 | 42 |
GO:001003830 | Thyroid | HT | response to metal ion | 50/1272 | 373/18723 | 3.12e-06 | 1.08e-04 | 50 |
GO:003428428 | Thyroid | HT | response to monosaccharide | 34/1272 | 225/18723 | 9.32e-06 | 2.59e-04 | 34 |
GO:000974329 | Thyroid | HT | response to carbohydrate | 36/1272 | 253/18723 | 2.00e-05 | 4.63e-04 | 36 |
GO:190165426 | Thyroid | HT | response to ketone | 29/1272 | 194/18723 | 5.04e-05 | 9.95e-04 | 29 |
GO:000691325 | Thyroid | HT | nucleocytoplasmic transport | 39/1272 | 301/18723 | 7.81e-05 | 1.38e-03 | 39 |
GO:005116925 | Thyroid | HT | nuclear transport | 39/1272 | 301/18723 | 7.81e-05 | 1.38e-03 | 39 |
GO:000974625 | Thyroid | HT | response to hexose | 31/1272 | 219/18723 | 8.12e-05 | 1.41e-03 | 31 |
GO:000974920 | Thyroid | HT | response to glucose | 29/1272 | 212/18723 | 2.47e-04 | 3.45e-03 | 29 |
GO:000941026 | Thyroid | HT | response to xenobiotic stimulus | 50/1272 | 462/18723 | 7.49e-04 | 8.32e-03 | 50 |
GO:000961219 | Thyroid | HT | response to mechanical stimulus | 28/1272 | 216/18723 | 7.49e-04 | 8.32e-03 | 28 |
GO:001703820 | Thyroid | HT | protein import | 27/1272 | 206/18723 | 7.79e-04 | 8.53e-03 | 27 |
GO:00023473 | Thyroid | HT | response to tumor cell | 9/1272 | 39/18723 | 9.90e-04 | 1.01e-02 | 9 |
GO:005159218 | Thyroid | HT | response to calcium ion | 19/1272 | 149/18723 | 5.92e-03 | 3.76e-02 | 19 |
GO:0072594112 | Thyroid | PTC | establishment of protein localization to organelle | 244/5968 | 422/18723 | 1.18e-28 | 4.97e-26 | 244 |
GO:0006913112 | Thyroid | PTC | nucleocytoplasmic transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
GO:0051169112 | Thyroid | PTC | nuclear transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046213 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
hsa0462112 | Cervix | CC | NOD-like receptor signaling pathway | 41/1267 | 186/8465 | 5.90e-03 | 1.95e-02 | 1.15e-02 | 41 |
hsa046219 | Esophagus | HGIN | NOD-like receptor signaling pathway | 45/1383 | 186/8465 | 3.40e-03 | 2.54e-02 | 2.02e-02 | 45 |
hsa0462114 | Esophagus | HGIN | NOD-like receptor signaling pathway | 45/1383 | 186/8465 | 3.40e-03 | 2.54e-02 | 2.02e-02 | 45 |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa0462132 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa046218 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462113 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462121 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa0462131 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXNIP | SNV | Missense_Mutation | c.511N>G | p.Met171Val | p.M171V | Q9H3M7 | protein_coding | tolerated(0.05) | benign(0.007) | TCGA-A1-A0SP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||
TXNIP | SNV | Missense_Mutation | c.392N>A | p.Arg131His | p.R131H | Q9H3M7 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
TXNIP | insertion | In_Frame_Ins | novel | c.267_268insCAG | p.Val89_Ile90insGln | p.V89_I90insQ | Q9H3M7 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TXNIP | insertion | Frame_Shift_Ins | novel | c.265_266insAGGTTGCAGTGAGCCCAGAC | p.Val89GlufsTer8 | p.V89Efs*8 | Q9H3M7 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TXNIP | deletion | Frame_Shift_Del | novel | c.705_708delNNNN | p.Val237GlufsTer40 | p.V237Efs*40 | Q9H3M7 | protein_coding | TCGA-DS-A3LQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
TXNIP | SNV | Missense_Mutation | c.26N>A | p.Ser9Tyr | p.S9Y | Q9H3M7 | protein_coding | deleterious(0.01) | benign(0.025) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TXNIP | SNV | Missense_Mutation | c.561N>C | p.Lys187Asn | p.K187N | Q9H3M7 | protein_coding | deleterious(0) | possibly_damaging(0.543) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TXNIP | SNV | Missense_Mutation | c.1141G>A | p.Val381Met | p.V381M | Q9H3M7 | protein_coding | deleterious(0.02) | benign(0.017) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TXNIP | SNV | Missense_Mutation | c.26C>A | p.Ser9Tyr | p.S9Y | Q9H3M7 | protein_coding | deleterious(0.01) | benign(0.025) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TXNIP | insertion | In_Frame_Ins | novel | c.989-1_989insTAAAGATGA | p.Ala330delinsValLysMetThr | p.A330delinsVKMT | Q9H3M7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10628 | TXNIP | TRANSCRIPTION FACTOR | FAS-LIGAND | 12706526 |
Page: 1 |