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Gene: SUN2 |
Gene summary for SUN2 |
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Gene information | Species | Human | Gene symbol | SUN2 | Gene ID | 25777 |
Gene name | Sad1 and UNC84 domain containing 2 | |
Gene Alias | UNC84B | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4E2A6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25777 | SUN2 | LZE2T | Human | Esophagus | ESCC | 2.61e-06 | 5.79e-01 | 0.082 |
25777 | SUN2 | LZE4T | Human | Esophagus | ESCC | 2.56e-08 | 2.42e-02 | 0.0811 |
25777 | SUN2 | LZE7T | Human | Esophagus | ESCC | 2.43e-04 | 1.08e-01 | 0.0667 |
25777 | SUN2 | LZE20T | Human | Esophagus | ESCC | 6.89e-04 | 1.13e-01 | 0.0662 |
25777 | SUN2 | LZE24T | Human | Esophagus | ESCC | 9.03e-07 | -1.59e-02 | 0.0596 |
25777 | SUN2 | LZE6T | Human | Esophagus | ESCC | 4.84e-02 | 1.35e-02 | 0.0845 |
25777 | SUN2 | P1T-E | Human | Esophagus | ESCC | 1.58e-11 | 7.04e-01 | 0.0875 |
25777 | SUN2 | P2T-E | Human | Esophagus | ESCC | 4.77e-16 | 5.14e-01 | 0.1177 |
25777 | SUN2 | P4T-E | Human | Esophagus | ESCC | 8.63e-17 | 3.91e-01 | 0.1323 |
25777 | SUN2 | P8T-E | Human | Esophagus | ESCC | 3.61e-21 | 3.94e-01 | 0.0889 |
25777 | SUN2 | P9T-E | Human | Esophagus | ESCC | 1.34e-06 | 1.26e-01 | 0.1131 |
25777 | SUN2 | P10T-E | Human | Esophagus | ESCC | 1.12e-07 | 6.63e-01 | 0.116 |
25777 | SUN2 | P11T-E | Human | Esophagus | ESCC | 1.24e-18 | 6.59e-01 | 0.1426 |
25777 | SUN2 | P12T-E | Human | Esophagus | ESCC | 2.50e-21 | 3.02e-01 | 0.1122 |
25777 | SUN2 | P15T-E | Human | Esophagus | ESCC | 4.87e-19 | 6.97e-01 | 0.1149 |
25777 | SUN2 | P16T-E | Human | Esophagus | ESCC | 3.18e-21 | 6.68e-01 | 0.1153 |
25777 | SUN2 | P17T-E | Human | Esophagus | ESCC | 2.99e-09 | 5.22e-01 | 0.1278 |
25777 | SUN2 | P19T-E | Human | Esophagus | ESCC | 1.09e-09 | 6.77e-01 | 0.1662 |
25777 | SUN2 | P20T-E | Human | Esophagus | ESCC | 1.63e-11 | 1.55e-01 | 0.1124 |
25777 | SUN2 | P21T-E | Human | Esophagus | ESCC | 1.35e-26 | 7.52e-01 | 0.1617 |
Page: 1 2 3 4 5 6 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004683114 | Skin | cSCC | regulation of RNA export from nucleus | 8/4864 | 12/18723 | 3.61e-03 | 1.94e-02 | 8 |
GO:004348915 | Skin | cSCC | RNA stabilization | 27/4864 | 65/18723 | 4.45e-03 | 2.29e-02 | 27 |
GO:005123527 | Skin | cSCC | maintenance of location | 106/4864 | 327/18723 | 5.17e-03 | 2.61e-02 | 106 |
GO:00094513 | Skin | cSCC | RNA modification | 58/4864 | 167/18723 | 7.33e-03 | 3.47e-02 | 58 |
GO:005165128 | Skin | cSCC | maintenance of location in cell | 72/4864 | 214/18723 | 7.37e-03 | 3.47e-02 | 72 |
GO:009951523 | Skin | cSCC | actin filament-based transport | 11/4864 | 21/18723 | 8.71e-03 | 4.01e-02 | 11 |
GO:004886317 | Skin | cSCC | stem cell differentiation | 69/4864 | 206/18723 | 9.56e-03 | 4.30e-02 | 69 |
GO:0032386111 | Thyroid | PTC | regulation of intracellular transport | 202/5968 | 337/18723 | 1.12e-26 | 3.93e-24 | 202 |
GO:0006913112 | Thyroid | PTC | nucleocytoplasmic transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
GO:0051169112 | Thyroid | PTC | nuclear transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
GO:0006403112 | Thyroid | PTC | RNA localization | 130/5968 | 201/18723 | 9.23e-22 | 1.94e-19 | 130 |
GO:0034504111 | Thyroid | PTC | protein localization to nucleus | 170/5968 | 290/18723 | 3.34e-21 | 6.38e-19 | 170 |
GO:003447018 | Thyroid | PTC | ncRNA processing | 215/5968 | 395/18723 | 7.14e-21 | 1.22e-18 | 215 |
GO:0006401112 | Thyroid | PTC | RNA catabolic process | 163/5968 | 278/18723 | 2.13e-20 | 3.27e-18 | 163 |
GO:0051168112 | Thyroid | PTC | nuclear export | 102/5968 | 154/18723 | 1.78e-18 | 2.01e-16 | 102 |
GO:0034655112 | Thyroid | PTC | nucleobase-containing compound catabolic process | 211/5968 | 407/18723 | 2.72e-17 | 2.52e-15 | 211 |
GO:004682223 | Thyroid | PTC | regulation of nucleocytoplasmic transport | 76/5968 | 106/18723 | 4.11e-17 | 3.70e-15 | 76 |
GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUN2 | SNV | Missense_Mutation | c.1171T>A | p.Ser391Thr | p.S391T | Q9UH99 | protein_coding | tolerated(0.39) | benign(0.014) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
SUN2 | SNV | Missense_Mutation | rs142901119 | c.1106N>A | p.Arg369His | p.R369H | Q9UH99 | protein_coding | tolerated(0.15) | benign(0.033) | TCGA-WT-AB44-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
SUN2 | SNV | Missense_Mutation | c.2203N>A | p.Glu735Lys | p.E735K | Q9UH99 | protein_coding | deleterious(0) | benign(0.151) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
SUN2 | SNV | Missense_Mutation | c.686N>T | p.Ser229Leu | p.S229L | Q9UH99 | protein_coding | tolerated(0.41) | benign(0.21) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SUN2 | SNV | Missense_Mutation | rs142753729 | c.277N>A | p.Ala93Thr | p.A93T | Q9UH99 | protein_coding | tolerated(0.73) | benign(0.026) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SUN2 | SNV | Missense_Mutation | c.481C>A | p.Pro161Thr | p.P161T | Q9UH99 | protein_coding | tolerated(0.57) | benign(0.051) | TCGA-WL-A834-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
SUN2 | SNV | Missense_Mutation | rs145042745 | c.661N>A | p.Val221Ile | p.V221I | Q9UH99 | protein_coding | deleterious(0.01) | probably_damaging(0.945) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SUN2 | SNV | Missense_Mutation | rs752409009 | c.734N>T | p.Thr245Met | p.T245M | Q9UH99 | protein_coding | deleterious(0.02) | possibly_damaging(0.742) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUN2 | SNV | Missense_Mutation | rs752150588 | c.1775N>T | p.Thr592Met | p.T592M | Q9UH99 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SUN2 | SNV | Missense_Mutation | c.2023N>T | p.Asp675Tyr | p.D675Y | Q9UH99 | protein_coding | deleterious(0) | possibly_damaging(0.725) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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