Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ROCK1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ROCK1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ROCK1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ROCK1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ROCK1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ROCK1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ROCK1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00435882 | Lung | IAC | skin development | 49/2061 | 263/18723 | 1.56e-04 | 2.82e-03 | 49 |
GO:00070438 | Lung | IAC | cell-cell junction assembly | 31/2061 | 146/18723 | 2.38e-04 | 4.06e-03 | 31 |
GO:00990034 | Lung | IAC | vesicle-mediated transport in synapse | 39/2061 | 200/18723 | 2.71e-04 | 4.49e-03 | 39 |
GO:00434103 | Lung | IAC | positive regulation of MAPK cascade | 78/2061 | 480/18723 | 2.72e-04 | 4.50e-03 | 78 |
GO:00019546 | Lung | IAC | positive regulation of cell-matrix adhesion | 16/2061 | 58/18723 | 3.85e-04 | 5.87e-03 | 16 |
GO:0045604 | Lung | IAC | regulation of epidermal cell differentiation | 16/2061 | 58/18723 | 3.85e-04 | 5.87e-03 | 16 |
GO:00708305 | Lung | IAC | bicellular tight junction assembly | 18/2061 | 70/18723 | 4.40e-04 | 6.51e-03 | 18 |
GO:0045682 | Lung | IAC | regulation of epidermis development | 17/2061 | 65/18723 | 5.07e-04 | 7.33e-03 | 17 |
GO:00518943 | Lung | IAC | positive regulation of focal adhesion assembly | 10/2061 | 28/18723 | 5.17e-04 | 7.37e-03 | 10 |
GO:00353085 | Lung | IAC | negative regulation of protein dephosphorylation | 11/2061 | 34/18723 | 7.21e-04 | 9.59e-03 | 11 |
GO:00433938 | Lung | IAC | regulation of protein binding | 37/2061 | 196/18723 | 7.28e-04 | 9.60e-03 | 37 |
GO:00511007 | Lung | IAC | negative regulation of binding | 32/2061 | 162/18723 | 7.30e-04 | 9.60e-03 | 32 |
GO:00031587 | Lung | IAC | endothelium development | 28/2061 | 136/18723 | 7.79e-04 | 1.01e-02 | 28 |
GO:00458618 | Lung | IAC | negative regulation of proteolysis | 58/2061 | 351/18723 | 1.04e-03 | 1.24e-02 | 58 |
GO:00030124 | Lung | IAC | muscle system process | 71/2061 | 452/18723 | 1.29e-03 | 1.45e-02 | 71 |
GO:00099135 | Lung | IAC | epidermal cell differentiation | 37/2061 | 202/18723 | 1.29e-03 | 1.45e-02 | 37 |
GO:00705073 | Lung | IAC | regulation of microtubule cytoskeleton organization | 29/2061 | 148/18723 | 1.44e-03 | 1.55e-02 | 29 |
GO:00353038 | Lung | IAC | regulation of dephosphorylation | 26/2061 | 128/18723 | 1.45e-03 | 1.55e-02 | 26 |
GO:00071596 | Lung | IAC | leukocyte cell-cell adhesion | 60/2061 | 371/18723 | 1.47e-03 | 1.57e-02 | 60 |
GO:00301006 | Lung | IAC | regulation of endocytosis | 38/2061 | 211/18723 | 1.54e-03 | 1.64e-02 | 38 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ROCK1 | SNV | Missense_Mutation | | c.1741C>G | p.Leu581Val | p.L581V | Q13464 | protein_coding | tolerated(0.29) | benign(0.01) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
ROCK1 | SNV | Missense_Mutation | | c.3607N>A | p.Glu1203Lys | p.E1203K | Q13464 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A7-A26G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
ROCK1 | SNV | Missense_Mutation | | c.3989N>A | p.Arg1330Gln | p.R1330Q | Q13464 | protein_coding | deleterious(0.02) | benign(0.227) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROCK1 | SNV | Missense_Mutation | | c.808N>A | p.Glu270Lys | p.E270K | Q13464 | protein_coding | deleterious(0.01) | possibly_damaging(0.805) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROCK1 | SNV | Missense_Mutation | | c.509N>C | p.Val170Ala | p.V170A | Q13464 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROCK1 | SNV | Missense_Mutation | | c.3490N>T | p.Pro1164Ser | p.P1164S | Q13464 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
ROCK1 | SNV | Missense_Mutation | rs761438534 | c.3146N>G | p.Asn1049Ser | p.N1049S | Q13464 | protein_coding | tolerated(0.17) | benign(0.024) | TCGA-LD-A66U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ROCK1 | insertion | Frame_Shift_Ins | novel | c.290_291insT | p.Thr98HisfsTer14 | p.T98Hfs*14 | Q13464 | protein_coding | | | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ROCK1 | insertion | Frame_Shift_Ins | novel | c.289_290insACAGAAGATATAGAAAACTTAAT | p.Ser97TyrfsTer16 | p.S97Yfs*16 | Q13464 | protein_coding | | | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ROCK1 | insertion | Frame_Shift_Ins | novel | c.3011_3012insAC | p.Asn1004LysfsTer7 | p.N1004Kfs*7 | Q13464 | protein_coding | | | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 336446944 | | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | CHEMBL3545065 | VEROSUDIL | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | Rhopressa | NETARSUDIL DIMESYLATE | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | BAY-613606 | CHEMBL541400 | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | inhibitor | 310264692 | VEROSUDIL | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | PMID28048944-Compound-7 | | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | DNDI1417467 | CHEMBL1997335 | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | FASUDIL | FASUDIL | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | PMID28048944-Compound-6 | | |
6093 | ROCK1 | KINASE, DRUGGABLE GENOME, ENZYME, SERINE THREONINE KINASE | | SP-600125 | SP-600125 | |