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Gene: DDX1 |
Gene summary for DDX1 |
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Gene information | Species | Human | Gene symbol | DDX1 | Gene ID | 1653 |
Gene name | DEAD-box helicase 1 | |
Gene Alias | DBP-RB | |
Cytomap | 2p24.3 | |
Gene Type | protein-coding | GO ID | GO:0000245 | UniProtAcc | A3RJH1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1653 | DDX1 | LZE2T | Human | Esophagus | ESCC | 1.99e-02 | 4.31e-01 | 0.082 |
1653 | DDX1 | LZE4T | Human | Esophagus | ESCC | 1.19e-10 | 4.16e-01 | 0.0811 |
1653 | DDX1 | LZE7T | Human | Esophagus | ESCC | 3.17e-05 | 3.15e-01 | 0.0667 |
1653 | DDX1 | LZE8T | Human | Esophagus | ESCC | 8.09e-03 | 7.79e-02 | 0.067 |
1653 | DDX1 | LZE20T | Human | Esophagus | ESCC | 1.02e-04 | 4.22e-02 | 0.0662 |
1653 | DDX1 | LZE22T | Human | Esophagus | ESCC | 7.06e-03 | 3.14e-01 | 0.068 |
1653 | DDX1 | LZE24T | Human | Esophagus | ESCC | 1.96e-08 | 2.56e-01 | 0.0596 |
1653 | DDX1 | P1T-E | Human | Esophagus | ESCC | 7.30e-06 | 3.18e-01 | 0.0875 |
1653 | DDX1 | P2T-E | Human | Esophagus | ESCC | 3.19e-30 | 6.22e-01 | 0.1177 |
1653 | DDX1 | P4T-E | Human | Esophagus | ESCC | 1.57e-22 | 6.00e-01 | 0.1323 |
1653 | DDX1 | P5T-E | Human | Esophagus | ESCC | 5.32e-13 | 2.61e-01 | 0.1327 |
1653 | DDX1 | P8T-E | Human | Esophagus | ESCC | 2.45e-21 | 3.62e-01 | 0.0889 |
1653 | DDX1 | P9T-E | Human | Esophagus | ESCC | 3.80e-15 | 3.76e-01 | 0.1131 |
1653 | DDX1 | P10T-E | Human | Esophagus | ESCC | 2.64e-36 | 5.99e-01 | 0.116 |
1653 | DDX1 | P11T-E | Human | Esophagus | ESCC | 1.50e-13 | 5.19e-01 | 0.1426 |
1653 | DDX1 | P12T-E | Human | Esophagus | ESCC | 1.70e-33 | 6.09e-01 | 0.1122 |
1653 | DDX1 | P15T-E | Human | Esophagus | ESCC | 1.73e-13 | 1.94e-01 | 0.1149 |
1653 | DDX1 | P16T-E | Human | Esophagus | ESCC | 1.53e-13 | 2.62e-01 | 0.1153 |
1653 | DDX1 | P17T-E | Human | Esophagus | ESCC | 3.51e-06 | 2.66e-01 | 0.1278 |
1653 | DDX1 | P19T-E | Human | Esophagus | ESCC | 7.37e-04 | 4.47e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004312212 | Liver | HCC | regulation of I-kappaB kinase/NF-kappaB signaling | 138/7958 | 249/18723 | 2.47e-05 | 2.58e-04 | 138 |
GO:001058611 | Liver | HCC | miRNA metabolic process | 22/7958 | 27/18723 | 3.97e-05 | 3.90e-04 | 22 |
GO:005110012 | Liver | HCC | negative regulation of binding | 94/7958 | 162/18723 | 4.69e-05 | 4.50e-04 | 94 |
GO:005105411 | Liver | HCC | positive regulation of DNA metabolic process | 113/7958 | 201/18723 | 5.76e-05 | 5.33e-04 | 113 |
GO:003209112 | Liver | HCC | negative regulation of protein binding | 59/7958 | 94/18723 | 5.79e-05 | 5.34e-04 | 59 |
GO:200102211 | Liver | HCC | positive regulation of response to DNA damage stimulus | 64/7958 | 105/18723 | 1.03e-04 | 8.88e-04 | 64 |
GO:000975521 | Liver | HCC | hormone-mediated signaling pathway | 106/7958 | 190/18723 | 1.45e-04 | 1.17e-03 | 106 |
GO:003052121 | Liver | HCC | androgen receptor signaling pathway | 31/7958 | 44/18723 | 1.63e-04 | 1.30e-03 | 31 |
GO:003206911 | Liver | HCC | regulation of nuclease activity | 18/7958 | 22/18723 | 1.91e-04 | 1.49e-03 | 18 |
GO:00323552 | Liver | HCC | response to estradiol | 81/7958 | 141/18723 | 2.39e-04 | 1.79e-03 | 81 |
GO:0009303 | Liver | HCC | rRNA transcription | 25/7958 | 34/18723 | 2.42e-04 | 1.81e-03 | 25 |
GO:0006360 | Liver | HCC | transcription by RNA polymerase I | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:003239211 | Liver | HCC | DNA geometric change | 54/7958 | 90/18723 | 6.04e-04 | 3.79e-03 | 54 |
GO:00062824 | Liver | HCC | regulation of DNA repair | 74/7958 | 130/18723 | 6.27e-04 | 3.89e-03 | 74 |
GO:00900683 | Liver | HCC | positive regulation of cell cycle process | 125/7958 | 236/18723 | 7.21e-04 | 4.40e-03 | 125 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:003052021 | Liver | HCC | intracellular estrogen receptor signaling pathway | 35/7958 | 54/18723 | 7.73e-04 | 4.65e-03 | 35 |
GO:0006356 | Liver | HCC | regulation of transcription by RNA polymerase I | 24/7958 | 34/18723 | 8.62e-04 | 5.13e-03 | 24 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:007124112 | Liver | HCC | cellular response to inorganic substance | 119/7958 | 226/18723 | 1.26e-03 | 6.92e-03 | 119 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX1 | SNV | Missense_Mutation | c.2095N>A | p.Gly699Arg | p.G699R | Q92499 | protein_coding | tolerated(0.22) | benign(0.303) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
DDX1 | SNV | Missense_Mutation | novel | c.1433G>C | p.Gly478Ala | p.G478A | Q92499 | protein_coding | tolerated(0.09) | benign(0.255) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
DDX1 | SNV | Missense_Mutation | novel | c.449C>T | p.Ser150Phe | p.S150F | Q92499 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-EW-A423-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
DDX1 | SNV | Missense_Mutation | novel | c.351G>T | p.Lys117Asn | p.K117N | Q92499 | protein_coding | tolerated(0.06) | possibly_damaging(0.787) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DDX1 | SNV | Missense_Mutation | c.1925N>A | p.Arg642Lys | p.R642K | Q92499 | protein_coding | tolerated(0.82) | benign(0.003) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
DDX1 | SNV | Missense_Mutation | c.238N>G | p.Thr80Ala | p.T80A | Q92499 | protein_coding | tolerated(0.59) | benign(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
DDX1 | SNV | Missense_Mutation | c.387G>A | p.Met129Ile | p.M129I | Q92499 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DDX1 | SNV | Missense_Mutation | c.1757N>G | p.Tyr586Cys | p.Y586C | Q92499 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
DDX1 | SNV | Missense_Mutation | novel | c.1274N>C | p.Phe425Ser | p.F425S | Q92499 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DDX1 | SNV | Missense_Mutation | c.1859N>T | p.Ala620Val | p.A620V | Q92499 | protein_coding | deleterious(0.01) | possibly_damaging(0.776) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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