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Gene: CRK |
Gene summary for CRK |
Gene summary. |
Gene information | Species | Human | Gene symbol | CRK | Gene ID | 1398 |
Gene name | CRK proto-oncogene, adaptor protein | |
Gene Alias | CRKII | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | A0A0S2Z3K9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1398 | CRK | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.52e-02 | -1.71e-01 | 0.0155 |
1398 | CRK | HTA11_347_2000001011 | Human | Colorectum | AD | 5.62e-11 | 5.00e-01 | -0.1954 |
1398 | CRK | HTA11_411_2000001011 | Human | Colorectum | SER | 8.31e-05 | 8.78e-01 | -0.2602 |
1398 | CRK | HTA11_83_2000001011 | Human | Colorectum | SER | 4.62e-02 | 4.63e-01 | -0.1526 |
1398 | CRK | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.13e-05 | 6.12e-01 | -0.059 |
1398 | CRK | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.79e-02 | -1.96e-01 | 0.3859 |
1398 | CRK | A002-C-010 | Human | Colorectum | FAP | 2.08e-02 | -2.13e-01 | 0.242 |
1398 | CRK | A001-C-207 | Human | Colorectum | FAP | 1.95e-04 | -3.53e-01 | 0.1278 |
1398 | CRK | A015-C-203 | Human | Colorectum | FAP | 1.71e-22 | -3.60e-01 | -0.1294 |
1398 | CRK | A015-C-204 | Human | Colorectum | FAP | 7.64e-04 | -2.70e-01 | -0.0228 |
1398 | CRK | A014-C-040 | Human | Colorectum | FAP | 2.14e-02 | -4.20e-01 | -0.1184 |
1398 | CRK | A002-C-201 | Human | Colorectum | FAP | 1.76e-06 | -2.31e-01 | 0.0324 |
1398 | CRK | A001-C-119 | Human | Colorectum | FAP | 8.38e-04 | -3.59e-01 | -0.1557 |
1398 | CRK | A001-C-108 | Human | Colorectum | FAP | 1.18e-12 | -3.04e-01 | -0.0272 |
1398 | CRK | A002-C-205 | Human | Colorectum | FAP | 2.60e-13 | -3.06e-01 | -0.1236 |
1398 | CRK | A001-C-104 | Human | Colorectum | FAP | 5.59e-03 | -2.08e-01 | 0.0184 |
1398 | CRK | A015-C-005 | Human | Colorectum | FAP | 2.05e-05 | -3.24e-01 | -0.0336 |
1398 | CRK | A015-C-006 | Human | Colorectum | FAP | 4.68e-10 | -4.21e-01 | -0.0994 |
1398 | CRK | A015-C-106 | Human | Colorectum | FAP | 8.27e-09 | -1.98e-01 | -0.0511 |
1398 | CRK | A002-C-114 | Human | Colorectum | FAP | 5.30e-10 | -2.53e-01 | -0.1561 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697929 | Skin | cSCC | response to oxidative stress | 184/4864 | 446/18723 | 8.57e-13 | 4.89e-11 | 184 |
GO:000716327 | Skin | cSCC | establishment or maintenance of cell polarity | 103/4864 | 218/18723 | 9.44e-12 | 4.85e-10 | 103 |
GO:005109827 | Skin | cSCC | regulation of binding | 152/4864 | 363/18723 | 2.21e-11 | 1.10e-09 | 152 |
GO:000030228 | Skin | cSCC | response to reactive oxygen species | 97/4864 | 222/18723 | 6.88e-09 | 2.25e-07 | 97 |
GO:004254227 | Skin | cSCC | response to hydrogen peroxide | 68/4864 | 146/18723 | 6.10e-08 | 1.56e-06 | 68 |
GO:000726523 | Skin | cSCC | Ras protein signal transduction | 132/4864 | 337/18723 | 6.17e-08 | 1.57e-06 | 132 |
GO:003001025 | Skin | cSCC | establishment of cell polarity | 65/4864 | 143/18723 | 3.60e-07 | 7.18e-06 | 65 |
GO:004343426 | Skin | cSCC | response to peptide hormone | 150/4864 | 414/18723 | 2.11e-06 | 3.43e-05 | 150 |
GO:004206029 | Skin | cSCC | wound healing | 152/4864 | 422/18723 | 2.66e-06 | 4.26e-05 | 152 |
GO:001081027 | Skin | cSCC | regulation of cell-substrate adhesion | 88/4864 | 221/18723 | 4.26e-06 | 6.32e-05 | 88 |
GO:004339325 | Skin | cSCC | regulation of protein binding | 79/4864 | 196/18723 | 7.59e-06 | 1.04e-04 | 79 |
GO:003297029 | Skin | cSCC | regulation of actin filament-based process | 142/4864 | 397/18723 | 8.50e-06 | 1.13e-04 | 142 |
GO:002260427 | Skin | cSCC | regulation of cell morphogenesis | 114/4864 | 309/18723 | 1.34e-05 | 1.68e-04 | 114 |
GO:003158926 | Skin | cSCC | cell-substrate adhesion | 130/4864 | 363/18723 | 1.87e-05 | 2.23e-04 | 130 |
GO:003295629 | Skin | cSCC | regulation of actin cytoskeleton organization | 127/4864 | 358/18723 | 3.83e-05 | 4.13e-04 | 127 |
GO:001076925 | Skin | cSCC | regulation of cell morphogenesis involved in differentiation | 43/4864 | 96/18723 | 5.00e-05 | 5.18e-04 | 43 |
GO:007155917 | Skin | cSCC | response to transforming growth factor beta | 95/4864 | 256/18723 | 5.21e-05 | 5.31e-04 | 95 |
GO:007156025 | Skin | cSCC | cellular response to transforming growth factor beta stimulus | 92/4864 | 250/18723 | 9.65e-05 | 8.99e-04 | 92 |
GO:007137518 | Skin | cSCC | cellular response to peptide hormone stimulus | 104/4864 | 290/18723 | 1.15e-04 | 1.06e-03 | 104 |
GO:1900024110 | Skin | cSCC | regulation of substrate adhesion-dependent cell spreading | 28/4864 | 57/18723 | 1.47e-04 | 1.32e-03 | 28 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa04722 | Colorectum | AD | Neurotrophin signaling pathway | 50/2092 | 119/8465 | 2.28e-05 | 2.24e-04 | 1.43e-04 | 50 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa05220 | Colorectum | AD | Chronic myeloid leukemia | 31/2092 | 76/8465 | 1.41e-03 | 8.46e-03 | 5.39e-03 | 31 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa05211 | Colorectum | AD | Renal cell carcinoma | 28/2092 | 69/8465 | 2.58e-03 | 1.37e-02 | 8.75e-03 | 28 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa04012 | Colorectum | AD | ErbB signaling pathway | 31/2092 | 85/8465 | 1.02e-02 | 3.91e-02 | 2.50e-02 | 31 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa047221 | Colorectum | AD | Neurotrophin signaling pathway | 50/2092 | 119/8465 | 2.28e-05 | 2.24e-04 | 1.43e-04 | 50 |
hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa052201 | Colorectum | AD | Chronic myeloid leukemia | 31/2092 | 76/8465 | 1.41e-03 | 8.46e-03 | 5.39e-03 | 31 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRK | SNV | Missense_Mutation | novel | c.608N>A | p.Gly203Asp | p.G203D | P46108 | protein_coding | deleterious(0.03) | benign(0.006) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CRK | SNV | Missense_Mutation | novel | c.777G>T | p.Glu259Asp | p.E259D | P46108 | protein_coding | tolerated(0.07) | benign(0.118) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRK | SNV | Missense_Mutation | rs145983279 | c.562G>A | p.Glu188Lys | p.E188K | P46108 | protein_coding | deleterious(0.02) | benign(0.438) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CRK | SNV | Missense_Mutation | novel | c.795N>T | p.Lys265Asn | p.K265N | P46108 | protein_coding | deleterious(0.02) | probably_damaging(0.955) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CRK | SNV | Missense_Mutation | rs748897674 | c.686N>T | p.Pro229Leu | p.P229L | P46108 | protein_coding | deleterious(0.02) | benign(0.157) | TCGA-D1-A16R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRK | SNV | Missense_Mutation | novel | c.385N>A | p.Leu129Ile | p.L129I | P46108 | protein_coding | tolerated(0.23) | benign(0) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CRK | SNV | Missense_Mutation | novel | c.721N>G | p.Arg241Gly | p.R241G | P46108 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRK | deletion | Frame_Shift_Del | c.818delN | p.Gly273ValfsTer66 | p.G273Vfs*66 | P46108 | protein_coding | TCGA-55-7725-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CRK | SNV | Missense_Mutation | rs776920144 | c.559N>A | p.Val187Ile | p.V187I | P46108 | protein_coding | tolerated(0.09) | possibly_damaging(0.63) | TCGA-CN-5365-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CRK | SNV | Missense_Mutation | c.172N>G | p.Ser58Ala | p.S58A | P46108 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CH-5748-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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