Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510995 | Colorectum | CRC | positive regulation of binding | 36/2078 | 173/18723 | 1.42e-04 | 2.62e-03 | 36 |
GO:00434095 | Colorectum | CRC | negative regulation of MAPK cascade | 37/2078 | 180/18723 | 1.51e-04 | 2.74e-03 | 37 |
GO:00486084 | Colorectum | CRC | reproductive structure development | 72/2078 | 424/18723 | 1.55e-04 | 2.80e-03 | 72 |
GO:00300995 | Colorectum | CRC | myeloid cell differentiation | 66/2078 | 381/18723 | 1.59e-04 | 2.87e-03 | 66 |
GO:00605623 | Colorectum | CRC | epithelial tube morphogenesis | 58/2078 | 325/18723 | 1.74e-04 | 3.10e-03 | 58 |
GO:00106344 | Colorectum | CRC | positive regulation of epithelial cell migration | 36/2078 | 176/18723 | 2.04e-04 | 3.48e-03 | 36 |
GO:00106325 | Colorectum | CRC | regulation of epithelial cell migration | 53/2078 | 292/18723 | 2.11e-04 | 3.55e-03 | 53 |
GO:00302185 | Colorectum | CRC | erythrocyte differentiation | 27/2078 | 120/18723 | 2.50e-04 | 4.09e-03 | 27 |
GO:0001823 | Colorectum | CRC | mesonephros development | 23/2078 | 96/18723 | 2.68e-04 | 4.32e-03 | 23 |
GO:00085442 | Colorectum | CRC | epidermis development | 57/2078 | 324/18723 | 2.88e-04 | 4.59e-03 | 57 |
GO:0001657 | Colorectum | CRC | ureteric bud development | 22/2078 | 91/18723 | 3.14e-04 | 4.89e-03 | 22 |
GO:00302245 | Colorectum | CRC | monocyte differentiation | 12/2078 | 36/18723 | 3.29e-04 | 5.04e-03 | 12 |
GO:00097914 | Colorectum | CRC | post-embryonic development | 20/2078 | 80/18723 | 3.62e-04 | 5.45e-03 | 20 |
GO:0072163 | Colorectum | CRC | mesonephric epithelium development | 22/2078 | 92/18723 | 3.71e-04 | 5.55e-03 | 22 |
GO:0072164 | Colorectum | CRC | mesonephric tubule development | 22/2078 | 92/18723 | 3.71e-04 | 5.55e-03 | 22 |
GO:00351963 | Colorectum | CRC | production of miRNAs involved in gene silencing by miRNA | 15/2078 | 52/18723 | 3.74e-04 | 5.57e-03 | 15 |
GO:00022625 | Colorectum | CRC | myeloid cell homeostasis | 32/2078 | 157/18723 | 4.77e-04 | 6.90e-03 | 32 |
GO:00901325 | Colorectum | CRC | epithelium migration | 61/2078 | 360/18723 | 5.02e-04 | 7.11e-03 | 61 |
GO:00073693 | Colorectum | CRC | gastrulation | 36/2078 | 185/18723 | 5.54e-04 | 7.70e-03 | 36 |
GO:00513485 | Colorectum | CRC | negative regulation of transferase activity | 48/2078 | 268/18723 | 5.56e-04 | 7.70e-03 | 48 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa05418 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa054181 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
hsa049192 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa054182 | Colorectum | SER | Fluid shear stress and atherosclerosis | 40/1580 | 139/8465 | 2.28e-03 | 1.75e-02 | 1.27e-02 | 40 |
hsa049193 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa054183 | Colorectum | SER | Fluid shear stress and atherosclerosis | 40/1580 | 139/8465 | 2.28e-03 | 1.75e-02 | 1.27e-02 | 40 |
hsa049194 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa054184 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa049195 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa054185 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa054186 | Colorectum | MSI-H | Fluid shear stress and atherosclerosis | 25/797 | 139/8465 | 1.11e-03 | 1.20e-02 | 1.01e-02 | 25 |
hsa049196 | Colorectum | MSI-H | Thyroid hormone signaling pathway | 21/797 | 121/8465 | 4.18e-03 | 4.10e-02 | 3.44e-02 | 21 |
hsa054187 | Colorectum | MSI-H | Fluid shear stress and atherosclerosis | 25/797 | 139/8465 | 1.11e-03 | 1.20e-02 | 1.01e-02 | 25 |
hsa049197 | Colorectum | MSI-H | Thyroid hormone signaling pathway | 21/797 | 121/8465 | 4.18e-03 | 4.10e-02 | 3.44e-02 | 21 |
hsa049198 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa054188 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMP4 | SNV | Missense_Mutation | | c.404A>T | p.Asn135Ile | p.N135I | P12644 | protein_coding | tolerated(0.12) | benign(0.1) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BMP4 | SNV | Missense_Mutation | rs747238009 | c.340N>T | p.Ala114Ser | p.A114S | P12644 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
BMP4 | deletion | Frame_Shift_Del | novel | c.179delN | p.Thr60AsnfsTer58 | p.T60Nfs*58 | P12644 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
BMP4 | SNV | Missense_Mutation | rs750868626 | c.1223N>A | p.Arg408His | p.R408H | P12644 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMP4 | SNV | Missense_Mutation | rs773416502 | c.484N>T | p.Arg162Trp | p.R162W | P12644 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMP4 | SNV | Missense_Mutation | novel | c.646N>C | p.Asp216His | p.D216H | P12644 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
BMP4 | SNV | Missense_Mutation | | c.464N>G | p.Ser155Cys | p.S155C | P12644 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMP4 | SNV | Missense_Mutation | | c.313N>C | p.Glu105Gln | p.E105Q | P12644 | protein_coding | tolerated(0.7) | benign(0.015) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BMP4 | SNV | Missense_Mutation | novel | c.239N>T | p.Pro80Leu | p.P80L | P12644 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
BMP4 | SNV | Missense_Mutation | novel | c.1154A>G | p.Tyr385Cys | p.Y385C | P12644 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |