![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ACD |
Gene summary for ACD |
![]() |
Gene information | Species | Human | Gene symbol | ACD | Gene ID | 65057 |
Gene name | ACD shelterin complex subunit and telomerase recruitment factor | |
Gene Alias | PIP1 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | Q96AP0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65057 | ACD | LZE4T | Human | Esophagus | ESCC | 4.48e-08 | 1.68e-01 | 0.0811 |
65057 | ACD | LZE7T | Human | Esophagus | ESCC | 8.51e-08 | 6.98e-01 | 0.0667 |
65057 | ACD | LZE8T | Human | Esophagus | ESCC | 8.61e-08 | 2.01e-01 | 0.067 |
65057 | ACD | LZE20T | Human | Esophagus | ESCC | 2.95e-03 | 8.92e-02 | 0.0662 |
65057 | ACD | LZE22T | Human | Esophagus | ESCC | 1.69e-03 | 4.51e-01 | 0.068 |
65057 | ACD | LZE24T | Human | Esophagus | ESCC | 2.87e-22 | 4.15e-01 | 0.0596 |
65057 | ACD | LZE21T | Human | Esophagus | ESCC | 1.76e-04 | 3.23e-01 | 0.0655 |
65057 | ACD | LZE6T | Human | Esophagus | ESCC | 1.33e-02 | 2.02e-01 | 0.0845 |
65057 | ACD | P1T-E | Human | Esophagus | ESCC | 7.31e-13 | 4.61e-01 | 0.0875 |
65057 | ACD | P2T-E | Human | Esophagus | ESCC | 1.06e-20 | 3.55e-01 | 0.1177 |
65057 | ACD | P4T-E | Human | Esophagus | ESCC | 5.28e-25 | 5.89e-01 | 0.1323 |
65057 | ACD | P5T-E | Human | Esophagus | ESCC | 6.63e-19 | 4.29e-01 | 0.1327 |
65057 | ACD | P8T-E | Human | Esophagus | ESCC | 8.85e-34 | 6.47e-01 | 0.0889 |
65057 | ACD | P9T-E | Human | Esophagus | ESCC | 2.92e-12 | 2.14e-01 | 0.1131 |
65057 | ACD | P10T-E | Human | Esophagus | ESCC | 3.78e-17 | 2.84e-01 | 0.116 |
65057 | ACD | P11T-E | Human | Esophagus | ESCC | 5.43e-12 | 4.38e-01 | 0.1426 |
65057 | ACD | P12T-E | Human | Esophagus | ESCC | 3.04e-18 | 2.56e-01 | 0.1122 |
65057 | ACD | P15T-E | Human | Esophagus | ESCC | 1.18e-16 | 3.27e-01 | 0.1149 |
65057 | ACD | P16T-E | Human | Esophagus | ESCC | 9.04e-21 | 3.48e-01 | 0.1153 |
65057 | ACD | P17T-E | Human | Esophagus | ESCC | 1.04e-14 | 5.93e-01 | 0.1278 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000725415 | Prostate | Tumor | JNK cascade | 42/3246 | 167/18723 | 6.68e-03 | 3.05e-02 | 42 |
GO:004427211 | Prostate | Tumor | sulfur compound biosynthetic process | 38/3246 | 148/18723 | 6.69e-03 | 3.06e-02 | 38 |
GO:0035338 | Prostate | Tumor | long-chain fatty-acyl-CoA biosynthetic process | 8/3246 | 19/18723 | 1.00e-02 | 4.20e-02 | 8 |
GO:00338662 | Prostate | Tumor | nucleoside bisphosphate biosynthetic process | 18/3246 | 60/18723 | 1.10e-02 | 4.55e-02 | 18 |
GO:00340302 | Prostate | Tumor | ribonucleoside bisphosphate biosynthetic process | 18/3246 | 60/18723 | 1.10e-02 | 4.55e-02 | 18 |
GO:00340332 | Prostate | Tumor | purine nucleoside bisphosphate biosynthetic process | 18/3246 | 60/18723 | 1.10e-02 | 4.55e-02 | 18 |
GO:0016032113 | Thyroid | PTC | viral process | 236/5968 | 415/18723 | 2.48e-26 | 8.24e-24 | 236 |
GO:0019058113 | Thyroid | PTC | viral life cycle | 167/5968 | 317/18723 | 8.87e-15 | 5.89e-13 | 167 |
GO:000726519 | Thyroid | PTC | Ras protein signal transduction | 162/5968 | 337/18723 | 3.16e-10 | 1.02e-08 | 162 |
GO:0048524112 | Thyroid | PTC | positive regulation of viral process | 44/5968 | 65/18723 | 3.24e-09 | 8.76e-08 | 44 |
GO:0019079113 | Thyroid | PTC | viral genome replication | 74/5968 | 131/18723 | 4.85e-09 | 1.26e-07 | 74 |
GO:001969327 | Thyroid | PTC | ribose phosphate metabolic process | 176/5968 | 396/18723 | 8.28e-08 | 1.70e-06 | 176 |
GO:0050792113 | Thyroid | PTC | regulation of viral process | 85/5968 | 164/18723 | 8.33e-08 | 1.70e-06 | 85 |
GO:000915028 | Thyroid | PTC | purine ribonucleotide metabolic process | 165/5968 | 368/18723 | 1.03e-07 | 2.05e-06 | 165 |
GO:007252127 | Thyroid | PTC | purine-containing compound metabolic process | 182/5968 | 416/18723 | 1.92e-07 | 3.51e-06 | 182 |
GO:000925927 | Thyroid | PTC | ribonucleotide metabolic process | 170/5968 | 385/18723 | 2.32e-07 | 4.08e-06 | 170 |
GO:000724926 | Thyroid | PTC | I-kappaB kinase/NF-kappaB signaling | 130/5968 | 281/18723 | 2.78e-07 | 4.80e-06 | 130 |
GO:000616327 | Thyroid | PTC | purine nucleotide metabolic process | 170/5968 | 396/18723 | 2.02e-06 | 2.75e-05 | 170 |
GO:0031098111 | Thyroid | PTC | stress-activated protein kinase signaling cascade | 113/5968 | 247/18723 | 3.16e-06 | 4.10e-05 | 113 |
GO:000675325 | Thyroid | PTC | nucleoside phosphate metabolic process | 205/5968 | 497/18723 | 5.24e-06 | 6.35e-05 | 205 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACD | SNV | Missense_Mutation | c.229N>G | p.Pro77Ala | p.P77A | Q96AP0 | protein_coding | tolerated_low_confidence(0.84) | benign(0) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
ACD | deletion | Frame_Shift_Del | novel | c.1359delA | p.Lys453AsnfsTer10 | p.K453Nfs*10 | Q96AP0 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ACD | SNV | Missense_Mutation | c.874N>T | p.His292Tyr | p.H292Y | Q96AP0 | protein_coding | deleterious(0.01) | benign(0.091) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACD | SNV | Missense_Mutation | c.1006N>A | p.Glu336Lys | p.E336K | Q96AP0 | protein_coding | tolerated(0.07) | benign(0.078) | TCGA-FU-A5XV-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
ACD | insertion | Frame_Shift_Ins | novel | c.1206_1207insTGCTCAC | p.Pro403CysfsTer38 | p.P403Cfs*38 | Q96AP0 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
ACD | SNV | Missense_Mutation | rs747913250 | c.1405N>T | p.Arg469Trp | p.R469W | Q96AP0 | protein_coding | tolerated(0.25) | benign(0) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ACD | SNV | Missense_Mutation | rs762262197 | c.1261C>T | p.Arg421Cys | p.R421C | Q96AP0 | protein_coding | tolerated(0.19) | benign(0.057) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACD | SNV | Missense_Mutation | c.469G>A | p.Val157Met | p.V157M | Q96AP0 | protein_coding | tolerated(0.07) | probably_damaging(0.957) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ACD | SNV | Missense_Mutation | c.1217N>A | p.Cys406Tyr | p.C406Y | Q96AP0 | protein_coding | deleterious(0.04) | possibly_damaging(0.867) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACD | SNV | Missense_Mutation | rs781117606 | c.1409N>T | p.Pro470Leu | p.P470L | Q96AP0 | protein_coding | tolerated(0.09) | benign(0) | TCGA-G4-6306-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |