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Gene: UBQLN1 |
Gene summary for UBQLN1 |
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Gene information | Species | Human | Gene symbol | UBQLN1 | Gene ID | 29979 |
Gene name | ubiquilin 1 | |
Gene Alias | DA41 | |
Cytomap | 9q21.32 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9UMX0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29979 | UBQLN1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.91e-02 | 8.20e-01 | 0.3487 |
29979 | UBQLN1 | A015-C-203 | Human | Colorectum | FAP | 3.83e-14 | -3.04e-01 | -0.1294 |
29979 | UBQLN1 | A002-C-201 | Human | Colorectum | FAP | 4.83e-02 | -1.96e-01 | 0.0324 |
29979 | UBQLN1 | A001-C-108 | Human | Colorectum | FAP | 1.69e-09 | -2.63e-01 | -0.0272 |
29979 | UBQLN1 | A002-C-205 | Human | Colorectum | FAP | 3.94e-07 | -3.54e-01 | -0.1236 |
29979 | UBQLN1 | A015-C-006 | Human | Colorectum | FAP | 6.70e-04 | -3.22e-01 | -0.0994 |
29979 | UBQLN1 | A015-C-106 | Human | Colorectum | FAP | 6.82e-04 | -2.28e-01 | -0.0511 |
29979 | UBQLN1 | A002-C-114 | Human | Colorectum | FAP | 2.86e-05 | -3.30e-01 | -0.1561 |
29979 | UBQLN1 | A015-C-104 | Human | Colorectum | FAP | 8.09e-14 | -2.63e-01 | -0.1899 |
29979 | UBQLN1 | A001-C-014 | Human | Colorectum | FAP | 1.56e-06 | -2.56e-01 | 0.0135 |
29979 | UBQLN1 | A002-C-016 | Human | Colorectum | FAP | 1.70e-10 | -2.45e-01 | 0.0521 |
29979 | UBQLN1 | A015-C-002 | Human | Colorectum | FAP | 1.16e-02 | -2.60e-01 | -0.0763 |
29979 | UBQLN1 | A001-C-203 | Human | Colorectum | FAP | 7.63e-06 | -2.50e-01 | -0.0481 |
29979 | UBQLN1 | A002-C-116 | Human | Colorectum | FAP | 7.00e-17 | -2.79e-01 | -0.0452 |
29979 | UBQLN1 | A014-C-008 | Human | Colorectum | FAP | 2.28e-03 | -3.11e-01 | -0.191 |
29979 | UBQLN1 | A018-E-020 | Human | Colorectum | FAP | 2.45e-05 | -2.77e-01 | -0.2034 |
29979 | UBQLN1 | F034 | Human | Colorectum | FAP | 1.72e-12 | -3.14e-01 | -0.0665 |
29979 | UBQLN1 | F072B | Human | Colorectum | FAP | 1.08e-04 | -1.50e-01 | 0.257 |
29979 | UBQLN1 | LZE2T | Human | Esophagus | ESCC | 6.71e-05 | 4.33e-01 | 0.082 |
29979 | UBQLN1 | LZE4T | Human | Esophagus | ESCC | 1.96e-20 | 5.49e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003497627 | Thyroid | HT | response to endoplasmic reticulum stress | 41/1272 | 256/18723 | 2.43e-07 | 1.20e-05 | 41 |
GO:007048227 | Thyroid | HT | response to oxygen levels | 50/1272 | 347/18723 | 3.61e-07 | 1.65e-05 | 50 |
GO:006113630 | Thyroid | HT | regulation of proteasomal protein catabolic process | 33/1272 | 187/18723 | 3.78e-07 | 1.70e-05 | 33 |
GO:200005830 | Thyroid | HT | regulation of ubiquitin-dependent protein catabolic process | 30/1272 | 164/18723 | 5.75e-07 | 2.44e-05 | 30 |
GO:000989629 | Thyroid | HT | positive regulation of catabolic process | 63/1272 | 492/18723 | 8.49e-07 | 3.45e-05 | 63 |
GO:003243430 | Thyroid | HT | regulation of proteasomal ubiquitin-dependent protein catabolic process | 26/1272 | 134/18723 | 1.01e-06 | 3.99e-05 | 26 |
GO:003629327 | Thyroid | HT | response to decreased oxygen levels | 46/1272 | 322/18723 | 1.34e-06 | 5.14e-05 | 46 |
GO:003133129 | Thyroid | HT | positive regulation of cellular catabolic process | 56/1272 | 427/18723 | 1.63e-06 | 6.16e-05 | 56 |
GO:000166627 | Thyroid | HT | response to hypoxia | 44/1272 | 307/18723 | 2.07e-06 | 7.53e-05 | 44 |
GO:190040724 | Thyroid | HT | regulation of cellular response to oxidative stress | 19/1272 | 89/18723 | 6.62e-06 | 1.95e-04 | 19 |
GO:190320124 | Thyroid | HT | regulation of oxidative stress-induced cell death | 17/1272 | 74/18723 | 7.10e-06 | 2.04e-04 | 17 |
GO:190217525 | Thyroid | HT | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 10/1272 | 29/18723 | 1.23e-05 | 3.21e-04 | 10 |
GO:190288225 | Thyroid | HT | regulation of response to oxidative stress | 19/1272 | 98/18723 | 2.82e-05 | 6.13e-04 | 19 |
GO:001049829 | Thyroid | HT | proteasomal protein catabolic process | 57/1272 | 490/18723 | 4.84e-05 | 9.66e-04 | 57 |
GO:003647325 | Thyroid | HT | cell death in response to oxidative stress | 18/1272 | 95/18723 | 6.24e-05 | 1.16e-03 | 18 |
GO:190180026 | Thyroid | HT | positive regulation of proteasomal protein catabolic process | 20/1272 | 114/18723 | 7.81e-05 | 1.38e-03 | 20 |
GO:190305226 | Thyroid | HT | positive regulation of proteolysis involved in cellular protein catabolic process | 22/1272 | 133/18723 | 8.77e-05 | 1.48e-03 | 22 |
GO:003243626 | Thyroid | HT | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 17/1272 | 90/18723 | 1.03e-04 | 1.73e-03 | 17 |
GO:190589727 | Thyroid | HT | regulation of response to endoplasmic reticulum stress | 16/1272 | 82/18723 | 1.09e-04 | 1.81e-03 | 16 |
GO:000863124 | Thyroid | HT | intrinsic apoptotic signaling pathway in response to oxidative stress | 11/1272 | 45/18723 | 1.61e-04 | 2.43e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa050146 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa041416 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa050147 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa041417 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa050148 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa041418 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa050149 | Colorectum | FAP | Amyotrophic lateral sclerosis | 91/1404 | 364/8465 | 1.84e-05 | 2.36e-04 | 1.44e-04 | 91 |
hsa041419 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBQLN1 | SNV | Missense_Mutation | c.1615N>G | p.Gln539Glu | p.Q539E | Q9UMX0 | protein_coding | deleterious(0.02) | probably_damaging(0.943) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
UBQLN1 | SNV | Missense_Mutation | novel | c.1727N>C | p.Ile576Thr | p.I576T | Q9UMX0 | protein_coding | deleterious(0.05) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UBQLN1 | SNV | Missense_Mutation | c.1642N>G | p.Gln548Glu | p.Q548E | Q9UMX0 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-C5-A7CL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
UBQLN1 | SNV | Missense_Mutation | c.914N>T | p.Ser305Phe | p.S305F | Q9UMX0 | protein_coding | deleterious(0) | possibly_damaging(0.736) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
UBQLN1 | SNV | Missense_Mutation | c.567C>G | p.Ile189Met | p.I189M | Q9UMX0 | protein_coding | tolerated(0.16) | benign(0.062) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
UBQLN1 | SNV | Missense_Mutation | rs764735825 | c.162G>T | p.Glu54Asp | p.E54D | Q9UMX0 | protein_coding | tolerated(0.45) | probably_damaging(0.976) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
UBQLN1 | SNV | Missense_Mutation | c.407A>C | p.Asn136Thr | p.N136T | Q9UMX0 | protein_coding | tolerated(0.8) | benign(0.01) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
UBQLN1 | SNV | Missense_Mutation | c.1363T>C | p.Ser455Pro | p.S455P | Q9UMX0 | protein_coding | deleterious(0.02) | possibly_damaging(0.849) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBQLN1 | SNV | Missense_Mutation | novel | c.560N>C | p.Val187Ala | p.V187A | Q9UMX0 | protein_coding | tolerated(0.66) | benign(0.278) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UBQLN1 | SNV | Missense_Mutation | c.558N>T | p.Met186Ile | p.M186I | Q9UMX0 | protein_coding | deleterious(0.01) | benign(0.114) | TCGA-AZ-4614-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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