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Gene: TMOD3 |
Gene summary for TMOD3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMOD3 | Gene ID | 29766 |
| Gene name | tropomodulin 3 | |
| Gene Alias | UTMOD | |
| Cytomap | 15q21.2 | |
| Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q9NYL9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 29766 | TMOD3 | LZE2T | Human | Esophagus | ESCC | 7.95e-04 | 8.34e-01 | 0.082 |
| 29766 | TMOD3 | LZE4T | Human | Esophagus | ESCC | 1.91e-19 | 8.00e-01 | 0.0811 |
| 29766 | TMOD3 | LZE5T | Human | Esophagus | ESCC | 4.05e-04 | 9.78e-01 | 0.0514 |
| 29766 | TMOD3 | LZE7T | Human | Esophagus | ESCC | 1.49e-07 | 5.87e-01 | 0.0667 |
| 29766 | TMOD3 | LZE8T | Human | Esophagus | ESCC | 3.05e-12 | 5.22e-01 | 0.067 |
| 29766 | TMOD3 | LZE20T | Human | Esophagus | ESCC | 5.99e-09 | 3.77e-01 | 0.0662 |
| 29766 | TMOD3 | LZE22D1 | Human | Esophagus | HGIN | 3.30e-03 | 2.42e-01 | 0.0595 |
| 29766 | TMOD3 | LZE22T | Human | Esophagus | ESCC | 6.36e-05 | 4.53e-01 | 0.068 |
| 29766 | TMOD3 | LZE24T | Human | Esophagus | ESCC | 3.21e-20 | 5.56e-01 | 0.0596 |
| 29766 | TMOD3 | LZE21T | Human | Esophagus | ESCC | 3.23e-05 | 5.43e-01 | 0.0655 |
| 29766 | TMOD3 | LZE6T | Human | Esophagus | ESCC | 3.67e-09 | 7.54e-01 | 0.0845 |
| 29766 | TMOD3 | P1T-E | Human | Esophagus | ESCC | 5.09e-18 | 1.10e+00 | 0.0875 |
| 29766 | TMOD3 | P2T-E | Human | Esophagus | ESCC | 6.80e-28 | 4.10e-01 | 0.1177 |
| 29766 | TMOD3 | P4T-E | Human | Esophagus | ESCC | 5.40e-37 | 1.02e+00 | 0.1323 |
| 29766 | TMOD3 | P5T-E | Human | Esophagus | ESCC | 1.58e-44 | 8.31e-01 | 0.1327 |
| 29766 | TMOD3 | P8T-E | Human | Esophagus | ESCC | 8.45e-60 | 1.34e+00 | 0.0889 |
| 29766 | TMOD3 | P9T-E | Human | Esophagus | ESCC | 3.95e-28 | 8.37e-01 | 0.1131 |
| 29766 | TMOD3 | P10T-E | Human | Esophagus | ESCC | 6.83e-58 | 1.04e+00 | 0.116 |
| 29766 | TMOD3 | P11T-E | Human | Esophagus | ESCC | 1.56e-09 | 5.68e-01 | 0.1426 |
| 29766 | TMOD3 | P12T-E | Human | Esophagus | ESCC | 9.31e-34 | 7.48e-01 | 0.1122 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0032984110 | Thyroid | PTC | protein-containing complex disassembly | 114/5968 | 224/18723 | 2.26e-09 | 6.33e-08 | 114 |
| GO:0010639112 | Thyroid | PTC | negative regulation of organelle organization | 163/5968 | 348/18723 | 3.04e-09 | 8.39e-08 | 163 |
| GO:000806423 | Thyroid | PTC | regulation of actin polymerization or depolymerization | 98/5968 | 188/18723 | 6.00e-09 | 1.53e-07 | 98 |
| GO:003004125 | Thyroid | PTC | actin filament polymerization | 99/5968 | 191/18723 | 7.40e-09 | 1.85e-07 | 99 |
| GO:003083220 | Thyroid | PTC | regulation of actin filament length | 98/5968 | 189/18723 | 8.58e-09 | 2.10e-07 | 98 |
| GO:004578718 | Thyroid | PTC | positive regulation of cell cycle | 144/5968 | 313/18723 | 9.93e-08 | 1.99e-06 | 144 |
| GO:003083326 | Thyroid | PTC | regulation of actin filament polymerization | 88/5968 | 172/18723 | 1.07e-07 | 2.11e-06 | 88 |
| GO:19019908 | Thyroid | PTC | regulation of mitotic cell cycle phase transition | 138/5968 | 299/18723 | 1.44e-07 | 2.78e-06 | 138 |
| GO:0034101113 | Thyroid | PTC | erythrocyte homeostasis | 69/5968 | 129/18723 | 2.85e-07 | 4.90e-06 | 69 |
| GO:004593119 | Thyroid | PTC | positive regulation of mitotic cell cycle | 65/5968 | 121/18723 | 5.08e-07 | 8.26e-06 | 65 |
| GO:0048872113 | Thyroid | PTC | homeostasis of number of cells | 125/5968 | 272/18723 | 7.25e-07 | 1.14e-05 | 125 |
| GO:0002262113 | Thyroid | PTC | myeloid cell homeostasis | 79/5968 | 157/18723 | 1.11e-06 | 1.64e-05 | 79 |
| GO:0030218113 | Thyroid | PTC | erythrocyte differentiation | 63/5968 | 120/18723 | 2.14e-06 | 2.89e-05 | 63 |
| GO:19019878 | Thyroid | PTC | regulation of cell cycle phase transition | 167/5968 | 390/18723 | 2.97e-06 | 3.87e-05 | 167 |
| GO:0031032110 | Thyroid | PTC | actomyosin structure organization | 91/5968 | 196/18723 | 1.35e-05 | 1.45e-04 | 91 |
| GO:0030099113 | Thyroid | PTC | myeloid cell differentiation | 160/5968 | 381/18723 | 1.75e-05 | 1.82e-04 | 160 |
| GO:0031333112 | Thyroid | PTC | negative regulation of protein-containing complex assembly | 68/5968 | 141/18723 | 3.61e-05 | 3.37e-04 | 68 |
| GO:1902904111 | Thyroid | PTC | negative regulation of supramolecular fiber organization | 78/5968 | 167/18723 | 4.16e-05 | 3.80e-04 | 78 |
| GO:009006816 | Thyroid | PTC | positive regulation of cell cycle process | 103/5968 | 236/18723 | 9.03e-05 | 7.50e-04 | 103 |
| GO:00436247 | Thyroid | PTC | cellular protein complex disassembly | 64/5968 | 136/18723 | 1.49e-04 | 1.15e-03 | 64 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMOD3 | SNV | Missense_Mutation | c.473N>A | p.Gly158Asp | p.G158D | Q9NYL9 | protein_coding | tolerated(0.64) | benign(0.007) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | |
| TMOD3 | SNV | Missense_Mutation | novel | c.871G>T | p.Asp291Tyr | p.D291Y | Q9NYL9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
| TMOD3 | SNV | Missense_Mutation | novel | c.959N>T | p.Tyr320Phe | p.Y320F | Q9NYL9 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| TMOD3 | SNV | Missense_Mutation | rs757302528 | c.526N>A | p.Val176Ile | p.V176I | Q9NYL9 | protein_coding | tolerated(0.24) | benign(0.012) | TCGA-CI-6622-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
| TMOD3 | deletion | Frame_Shift_Del | rs759399045 | c.275delN | p.Ile97TyrfsTer23 | p.I97Yfs*23 | Q9NYL9 | protein_coding | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
| TMOD3 | SNV | Missense_Mutation | rs746856695 | c.833N>T | p.Ala278Val | p.A278V | Q9NYL9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0GW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TMOD3 | SNV | Missense_Mutation | novel | c.343N>A | p.Leu115Ile | p.L115I | Q9NYL9 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TMOD3 | SNV | Missense_Mutation | c.43C>A | p.Leu15Ile | p.L15I | Q9NYL9 | protein_coding | tolerated(1) | benign(0.107) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMOD3 | SNV | Missense_Mutation | c.311N>A | p.Pro104His | p.P104H | Q9NYL9 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMOD3 | SNV | Missense_Mutation | c.73T>C | p.Ser25Pro | p.S25P | Q9NYL9 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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