Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SREBF2

Gene summary for SREBF2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SREBF2

Gene ID

6721

Gene namesterol regulatory element binding transcription factor 2
Gene AliasSREBP-2
Cytomap22q13.2
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

A0A024R1Q0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6721SREBF2CCI_1HumanCervixCC4.86e-231.45e+000.528
6721SREBF2CCI_2HumanCervixCC8.35e-068.48e-010.5249
6721SREBF2CCI_3HumanCervixCC1.05e-341.67e+000.516
6721SREBF2HTA11_3410_2000001011HumanColorectumAD1.50e-10-4.53e-010.0155
6721SREBF2HTA11_2487_2000001011HumanColorectumSER2.26e-024.68e-01-0.1808
6721SREBF2HTA11_347_2000001011HumanColorectumAD7.12e-309.51e-01-0.1954
6721SREBF2HTA11_411_2000001011HumanColorectumSER4.58e-099.45e-01-0.2602
6721SREBF2HTA11_2112_2000001011HumanColorectumSER1.64e-136.99e-01-0.2196
6721SREBF2HTA11_83_2000001011HumanColorectumSER4.41e-096.81e-01-0.1526
6721SREBF2HTA11_696_2000001011HumanColorectumAD1.17e-097.15e-01-0.1464
6721SREBF2HTA11_546_2000001011HumanColorectumAD1.21e-025.42e-01-0.0842
6721SREBF2HTA11_866_3004761011HumanColorectumAD7.45e-05-4.78e-010.096
6721SREBF2HTA11_6818_2000001021HumanColorectumAD2.66e-03-4.07e-010.0588
6721SREBF2HTA11_99999965062_69753HumanColorectumMSI-H2.05e-101.09e+000.3487
6721SREBF2HTA11_99999974143_84620HumanColorectumMSS1.35e-22-6.55e-010.3005
6721SREBF2F007HumanColorectumFAP5.28e-03-4.54e-010.1176
6721SREBF2A002-C-010HumanColorectumFAP3.26e-10-4.35e-010.242
6721SREBF2A001-C-207HumanColorectumFAP8.00e-07-5.07e-010.1278
6721SREBF2A015-C-203HumanColorectumFAP4.60e-38-6.53e-01-0.1294
6721SREBF2A015-C-204HumanColorectumFAP4.89e-08-5.00e-01-0.0228
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:007265519Oral cavityLPestablishment of protein localization to mitochondrion68/4623120/187236.98e-147.16e-1268
GO:003238616Oral cavityLPregulation of intracellular transport145/4623337/187238.58e-148.27e-12145
GO:003238819Oral cavityLPpositive regulation of intracellular transport97/4623202/187234.79e-134.30e-1197
GO:003315719Oral cavityLPregulation of intracellular protein transport106/4623229/187237.85e-136.68e-11106
GO:000662619Oral cavityLPprotein targeting to mitochondrion58/4623100/187231.23e-121.00e-1058
GO:0022411110Oral cavityLPcellular component disassembly173/4623443/187239.97e-127.44e-10173
GO:001050615Oral cavityLPregulation of autophagy132/4623317/187231.82e-111.28e-09132
GO:1904951110Oral cavityLPpositive regulation of establishment of protein localization132/4623319/187233.06e-112.00e-09132
GO:009031615Oral cavityLPpositive regulation of intracellular protein transport78/4623160/187233.53e-112.28e-0978
GO:190300815Oral cavityLPorganelle disassembly60/4623114/187231.28e-107.30e-0960
GO:0051222110Oral cavityLPpositive regulation of protein transport123/4623303/187236.05e-102.96e-08123
GO:000698415Oral cavityLPER-nucleus signaling pathway30/462346/187237.25e-092.91e-0730
GO:0071496110Oral cavityLPcellular response to external stimulus124/4623320/187231.44e-085.36e-07124
GO:001082118Oral cavityLPregulation of mitochondrion organization65/4623144/187236.61e-082.24e-0665
GO:0031667110Oral cavityLPresponse to nutrient levels165/4623474/187233.87e-071.12e-05165
GO:000042215Oral cavityLPautophagy of mitochondrion41/462381/187234.23e-071.21e-0541
GO:006172615Oral cavityLPmitochondrion disassembly41/462381/187234.23e-071.21e-0541
GO:0031668110Oral cavityLPcellular response to extracellular stimulus91/4623246/187231.07e-051.94e-0491
GO:190353314Oral cavityLPregulation of protein targeting37/462381/187233.07e-054.74e-0437
GO:003166919Oral cavityLPcellular response to nutrient levels79/4623215/187235.16e-057.21e-0479
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
SREBF2ABSColorectumADACSS2,FDPS,SIPA1L3, etc.2.79e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SREBF2ABSColorectumSERACSS2,FDPS,SIPA1L3, etc.2.71e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SREBF2SMCPancreasHealthyHMGCS1,IDI1,CWC27, etc.6.36e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
SREBF2CAFPancreasPDACHMGCS1,IDI1,CWC27, etc.1.02e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SREBF2SNVMissense_Mutationc.1412N>Tp.Pro471Leup.P471LQ12772protein_codingdeleterious(0.02)benign(0.154)TCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
SREBF2SNVMissense_Mutationrs147747695c.2562N>Ap.Met854Ilep.M854IQ12772protein_codingdeleterious(0.04)benign(0)TCGA-BH-A0HP-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapydoxorubicinSD
SREBF2SNVMissense_Mutationc.1334N>Gp.Ser445Cysp.S445CQ12772protein_codingdeleterious(0)probably_damaging(0.997)TCGA-BH-A18U-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
SREBF2insertionFrame_Shift_Insnovelc.653_654insAAAAATTAGCp.Thr219LysfsTer99p.T219Kfs*99Q12772protein_codingTCGA-A8-A07J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
SREBF2insertionNonsense_Mutationnovelc.1267_1268insGATTAACCCAGGAAGAGTCTCAGACCTCATGAAGTACTGCCp.Asp423GlyfsTer11p.D423Gfs*11Q12772protein_codingTCGA-A8-A08H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SREBF2deletionFrame_Shift_Delnovelc.1435delCp.Arg479AlafsTer19p.R479Afs*19Q12772protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
SREBF2deletionFrame_Shift_Delnovelc.3047delGp.Gly1016AlafsTer26p.G1016Afs*26Q12772protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
SREBF2SNVMissense_Mutationrs200228342c.1418N>Tp.Ala473Valp.A473VQ12772protein_codingdeleterious(0.02)benign(0.266)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SREBF2SNVMissense_Mutationc.2674G>Ap.Asp892Asnp.D892NQ12772protein_codingdeleterious(0)probably_damaging(0.997)TCGA-LP-A4AV-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SREBF2SNVMissense_Mutationc.2661N>Tp.Trp887Cysp.W887CQ12772protein_codingdeleterious(0)probably_damaging(0.998)TCGA-ZJ-AAXD-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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