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Gene: SH3GLB1 |
Gene summary for SH3GLB1 |
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Gene information | Species | Human | Gene symbol | SH3GLB1 | Gene ID | 51100 |
Gene name | SH3 domain containing GRB2 like, endophilin B1 | |
Gene Alias | Bif-1 | |
Cytomap | 1p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | A0A087WW40 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51100 | SH3GLB1 | LZE2T | Human | Esophagus | ESCC | 1.92e-02 | 3.43e-01 | 0.082 |
51100 | SH3GLB1 | LZE4T | Human | Esophagus | ESCC | 2.57e-07 | 3.28e-01 | 0.0811 |
51100 | SH3GLB1 | LZE8T | Human | Esophagus | ESCC | 1.46e-12 | 1.89e-01 | 0.067 |
51100 | SH3GLB1 | LZE20T | Human | Esophagus | ESCC | 1.53e-05 | 5.54e-01 | 0.0662 |
51100 | SH3GLB1 | LZE22D1 | Human | Esophagus | HGIN | 1.47e-05 | 1.79e-01 | 0.0595 |
51100 | SH3GLB1 | LZE22T | Human | Esophagus | ESCC | 5.16e-09 | 2.29e-01 | 0.068 |
51100 | SH3GLB1 | LZE24T | Human | Esophagus | ESCC | 9.95e-20 | 6.67e-01 | 0.0596 |
51100 | SH3GLB1 | LZE21T | Human | Esophagus | ESCC | 3.42e-07 | 3.46e-02 | 0.0655 |
51100 | SH3GLB1 | LZE6T | Human | Esophagus | ESCC | 4.01e-06 | 3.08e-02 | 0.0845 |
51100 | SH3GLB1 | P1T-E | Human | Esophagus | ESCC | 2.33e-09 | 9.50e-01 | 0.0875 |
51100 | SH3GLB1 | P2T-E | Human | Esophagus | ESCC | 1.80e-39 | 6.46e-01 | 0.1177 |
51100 | SH3GLB1 | P4T-E | Human | Esophagus | ESCC | 7.76e-25 | 7.39e-01 | 0.1323 |
51100 | SH3GLB1 | P5T-E | Human | Esophagus | ESCC | 2.14e-36 | 9.61e-01 | 0.1327 |
51100 | SH3GLB1 | P8T-E | Human | Esophagus | ESCC | 3.36e-29 | 7.17e-01 | 0.0889 |
51100 | SH3GLB1 | P9T-E | Human | Esophagus | ESCC | 1.07e-12 | 5.82e-01 | 0.1131 |
51100 | SH3GLB1 | P10T-E | Human | Esophagus | ESCC | 1.14e-29 | 6.32e-01 | 0.116 |
51100 | SH3GLB1 | P11T-E | Human | Esophagus | ESCC | 7.21e-17 | 1.16e+00 | 0.1426 |
51100 | SH3GLB1 | P12T-E | Human | Esophagus | ESCC | 2.27e-94 | 2.19e+00 | 0.1122 |
51100 | SH3GLB1 | P15T-E | Human | Esophagus | ESCC | 5.64e-32 | 8.25e-01 | 0.1149 |
51100 | SH3GLB1 | P16T-E | Human | Esophagus | ESCC | 2.09e-24 | 3.21e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0031334113 | Thyroid | PTC | positive regulation of protein-containing complex assembly | 121/5968 | 237/18723 | 5.70e-10 | 1.81e-08 | 121 |
GO:000703315 | Thyroid | PTC | vacuole organization | 96/5968 | 180/18723 | 1.80e-09 | 5.13e-08 | 96 |
GO:190321416 | Thyroid | PTC | regulation of protein targeting to mitochondrion | 33/5968 | 44/18723 | 5.20e-09 | 1.34e-07 | 33 |
GO:190374718 | Thyroid | PTC | regulation of establishment of protein localization to mitochondrion | 36/5968 | 50/18723 | 6.68e-09 | 1.70e-07 | 36 |
GO:190353310 | Thyroid | PTC | regulation of protein targeting | 51/5968 | 81/18723 | 8.40e-09 | 2.07e-07 | 51 |
GO:001050810 | Thyroid | PTC | positive regulation of autophagy | 70/5968 | 124/18723 | 1.30e-08 | 3.08e-07 | 70 |
GO:0031668113 | Thyroid | PTC | cellular response to extracellular stimulus | 120/5968 | 246/18723 | 2.13e-08 | 4.91e-07 | 120 |
GO:0031669112 | Thyroid | PTC | cellular response to nutrient levels | 106/5968 | 215/18723 | 6.96e-08 | 1.44e-06 | 106 |
GO:0042594111 | Thyroid | PTC | response to starvation | 98/5968 | 197/18723 | 1.24e-07 | 2.41e-06 | 98 |
GO:0009267112 | Thyroid | PTC | cellular response to starvation | 80/5968 | 156/18723 | 3.52e-07 | 5.90e-06 | 80 |
GO:19039558 | Thyroid | PTC | positive regulation of protein targeting to mitochondrion | 24/5968 | 32/18723 | 6.76e-07 | 1.07e-05 | 24 |
GO:0031667113 | Thyroid | PTC | response to nutrient levels | 201/5968 | 474/18723 | 7.00e-07 | 1.10e-05 | 201 |
GO:190374910 | Thyroid | PTC | positive regulation of establishment of protein localization to mitochondrion | 26/5968 | 36/18723 | 7.90e-07 | 1.22e-05 | 26 |
GO:000004514 | Thyroid | PTC | autophagosome assembly | 54/5968 | 99/18723 | 2.46e-06 | 3.22e-05 | 54 |
GO:190503713 | Thyroid | PTC | autophagosome organization | 55/5968 | 103/18723 | 4.75e-06 | 5.79e-05 | 55 |
GO:190211516 | Thyroid | PTC | regulation of organelle assembly | 88/5968 | 186/18723 | 7.41e-06 | 8.65e-05 | 88 |
GO:000091019 | Thyroid | PTC | cytokinesis | 82/5968 | 173/18723 | 1.37e-05 | 1.47e-04 | 82 |
GO:007266518 | Thyroid | PTC | protein localization to vacuole | 38/5968 | 67/18723 | 2.28e-05 | 2.28e-04 | 38 |
GO:00162395 | Thyroid | PTC | positive regulation of macroautophagy | 36/5968 | 63/18723 | 2.98e-05 | 2.86e-04 | 36 |
GO:004311219 | Thyroid | PTC | receptor metabolic process | 77/5968 | 166/18723 | 6.21e-05 | 5.47e-04 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa041406 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414011 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa041409 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414014 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414024 | Oral cavity | LP | Autophagy - animal | 55/2418 | 141/8465 | 4.54e-03 | 1.87e-02 | 1.20e-02 | 55 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SH3GLB1 | SNV | Missense_Mutation | rs533090731 | c.878N>G | p.Asn293Ser | p.N293S | protein_coding | tolerated(0.87) | benign(0.077) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
SH3GLB1 | SNV | Missense_Mutation | rs777019424 | c.413N>T | p.Thr138Met | p.T138M | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-EK-A2RL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | taxol | PD | |
SH3GLB1 | SNV | Missense_Mutation | c.254N>C | p.Arg85Thr | p.R85T | protein_coding | deleterious(0.03) | probably_damaging(0.962) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SH3GLB1 | SNV | Missense_Mutation | c.926N>A | p.Gly309Asp | p.G309D | protein_coding | tolerated(0.28) | benign(0.088) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
SH3GLB1 | SNV | Missense_Mutation | novel | c.666N>T | p.Gln222His | p.Q222H | protein_coding | tolerated(0.41) | probably_damaging(0.978) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SH3GLB1 | SNV | Missense_Mutation | rs751120404 | c.618N>A | p.Phe206Leu | p.F206L | protein_coding | tolerated(0.79) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SH3GLB1 | SNV | Missense_Mutation | c.1181N>G | p.Asn394Ser | p.N394S | protein_coding | tolerated(1) | probably_damaging(0.999) | TCGA-G4-6625-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SH3GLB1 | SNV | Missense_Mutation | novel | c.427T>G | p.Phe143Val | p.F143V | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SH3GLB1 | SNV | Missense_Mutation | novel | c.940N>A | p.Ala314Thr | p.A314T | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SH3GLB1 | SNV | Missense_Mutation | novel | c.133N>A | p.Leu45Ile | p.L45I | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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