Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/PPP1CA_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PPP1CA_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PPP1CA_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/PPP1CA_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PPP1CA_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PPP1CA_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PPP1CA_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PPP1CA_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PPP1CA_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123815 | Prostate | Tumor | positive regulation of extrinsic apoptotic signaling pathway | 23/3246 | 48/18723 | 1.02e-06 | 1.96e-05 | 23 |
GO:006056214 | Prostate | Tumor | epithelial tube morphogenesis | 90/3246 | 325/18723 | 1.93e-06 | 3.34e-05 | 90 |
GO:006113813 | Prostate | Tumor | morphogenesis of a branching epithelium | 57/3246 | 182/18723 | 2.66e-06 | 4.45e-05 | 57 |
GO:005110018 | Prostate | Tumor | negative regulation of binding | 52/3246 | 162/18723 | 3.22e-06 | 5.29e-05 | 52 |
GO:004339317 | Prostate | Tumor | regulation of protein binding | 60/3246 | 196/18723 | 3.36e-06 | 5.45e-05 | 60 |
GO:004346715 | Prostate | Tumor | regulation of generation of precursor metabolites and energy | 43/3246 | 130/18723 | 9.55e-06 | 1.39e-04 | 43 |
GO:000647014 | Prostate | Tumor | protein dephosphorylation | 76/3246 | 281/18723 | 2.86e-05 | 3.46e-04 | 76 |
GO:004275214 | Prostate | Tumor | regulation of circadian rhythm | 39/3246 | 121/18723 | 4.69e-05 | 5.21e-04 | 39 |
GO:004347012 | Prostate | Tumor | regulation of carbohydrate catabolic process | 22/3246 | 56/18723 | 8.33e-05 | 8.38e-04 | 22 |
GO:000600613 | Prostate | Tumor | glucose metabolic process | 55/3246 | 196/18723 | 1.22e-04 | 1.14e-03 | 55 |
GO:003298413 | Prostate | Tumor | protein-containing complex disassembly | 61/3246 | 224/18723 | 1.36e-04 | 1.26e-03 | 61 |
GO:003209114 | Prostate | Tumor | negative regulation of protein binding | 31/3246 | 94/18723 | 1.69e-04 | 1.50e-03 | 31 |
GO:000931415 | Prostate | Tumor | response to radiation | 109/3246 | 456/18723 | 1.94e-04 | 1.70e-03 | 109 |
GO:000610912 | Prostate | Tumor | regulation of carbohydrate metabolic process | 50/3246 | 178/18723 | 2.36e-04 | 2.00e-03 | 50 |
GO:006201214 | Prostate | Tumor | regulation of small molecule metabolic process | 83/3246 | 334/18723 | 2.96e-04 | 2.39e-03 | 83 |
GO:003032314 | Prostate | Tumor | respiratory tube development | 49/3246 | 181/18723 | 6.80e-04 | 4.79e-03 | 49 |
GO:001631113 | Prostate | Tumor | dephosphorylation | 98/3246 | 417/18723 | 7.31e-04 | 5.08e-03 | 98 |
GO:003032415 | Prostate | Tumor | lung development | 48/3246 | 177/18723 | 7.35e-04 | 5.10e-03 | 48 |
GO:001605214 | Prostate | Tumor | carbohydrate catabolic process | 42/3246 | 154/18723 | 1.35e-03 | 8.44e-03 | 42 |
GO:00193187 | Prostate | Tumor | hexose metabolic process | 59/3246 | 237/18723 | 1.96e-03 | 1.14e-02 | 59 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1CA | insertion | In_Frame_Ins | novel | c.223_224insGACCCAGAAGCTCCAAGTTAC | p.Asp75delinsGlyProArgSerSerLysLeuHis | p.D75delinsGPRSSKLH | P62136 | protein_coding | | | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1CA | insertion | Frame_Shift_Ins | novel | c.221_222insCGGGAAGATCCCT | p.Asp75GlyfsTer5 | p.D75Gfs*5 | P62136 | protein_coding | | | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1CA | insertion | Frame_Shift_Ins | novel | c.348_349insGGAGT | p.Leu117GlyfsTer61 | p.L117Gfs*61 | P62136 | protein_coding | | | TCGA-BH-A0B9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PPP1CA | insertion | Frame_Shift_Ins | novel | c.347_348insTTTCTTTACTTTTTTGAGA | p.Leu117PhefsTer12 | p.L117Ffs*12 | P62136 | protein_coding | | | TCGA-BH-A0B9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PPP1CA | deletion | Frame_Shift_Del | novel | c.620delC | p.Pro207LeufsTer56 | p.P207Lfs*56 | P62136 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
PPP1CA | SNV | Missense_Mutation | | c.461N>A | p.Arg154His | p.R154H | P62136 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.966) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1CA | SNV | Missense_Mutation | novel | c.441N>A | p.Phe147Leu | p.F147L | P62136 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.727) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
PPP1CA | SNV | Missense_Mutation | | c.848N>G | p.Tyr283Cys | p.Y283C | P62136 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(1) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
PPP1CA | SNV | Missense_Mutation | novel | c.379N>A | p.Glu127Lys | p.E127K | P62136 | protein_coding | deleterious_low_confidence(0.01) | benign(0.057) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PPP1CA | SNV | Missense_Mutation | rs774510465 | c.931N>A | p.Asp311Asn | p.D311N | P62136 | protein_coding | deleterious_low_confidence(0.05) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |