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Gene: PCID2 |
Gene summary for PCID2 |
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Gene information | Species | Human | Gene symbol | PCID2 | Gene ID | 55795 |
Gene name | PCI domain containing 2 | |
Gene Alias | F10 | |
Cytomap | 13q34 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q5JVF3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55795 | PCID2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.01e-13 | 8.03e-01 | 0.281 |
55795 | PCID2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.99e-13 | 7.49e-01 | 0.3859 |
55795 | PCID2 | A015-C-203 | Human | Colorectum | FAP | 1.02e-05 | -9.66e-02 | -0.1294 |
55795 | PCID2 | A001-C-119 | Human | Colorectum | FAP | 1.39e-04 | -2.97e-01 | -0.1557 |
55795 | PCID2 | A001-C-108 | Human | Colorectum | FAP | 2.07e-03 | -1.16e-01 | -0.0272 |
55795 | PCID2 | A002-C-205 | Human | Colorectum | FAP | 3.71e-07 | -2.45e-01 | -0.1236 |
55795 | PCID2 | A015-C-006 | Human | Colorectum | FAP | 8.41e-03 | 6.79e-02 | -0.0994 |
55795 | PCID2 | A002-C-114 | Human | Colorectum | FAP | 2.89e-05 | -2.26e-01 | -0.1561 |
55795 | PCID2 | A015-C-104 | Human | Colorectum | FAP | 1.69e-10 | -2.31e-01 | -0.1899 |
55795 | PCID2 | A002-C-116 | Human | Colorectum | FAP | 2.17e-07 | -1.94e-01 | -0.0452 |
55795 | PCID2 | A014-C-008 | Human | Colorectum | FAP | 3.37e-02 | -2.11e-01 | -0.191 |
55795 | PCID2 | A018-E-020 | Human | Colorectum | FAP | 5.16e-03 | -1.60e-01 | -0.2034 |
55795 | PCID2 | F034 | Human | Colorectum | FAP | 2.46e-02 | -8.74e-02 | -0.0665 |
55795 | PCID2 | LZE4T | Human | Esophagus | ESCC | 1.23e-08 | 2.62e-01 | 0.0811 |
55795 | PCID2 | LZE7T | Human | Esophagus | ESCC | 1.68e-05 | 4.40e-01 | 0.0667 |
55795 | PCID2 | LZE8T | Human | Esophagus | ESCC | 1.68e-07 | 2.08e-01 | 0.067 |
55795 | PCID2 | LZE24T | Human | Esophagus | ESCC | 3.68e-07 | 2.02e-01 | 0.0596 |
55795 | PCID2 | LZE6T | Human | Esophagus | ESCC | 6.15e-04 | 3.68e-01 | 0.0845 |
55795 | PCID2 | P1T-E | Human | Esophagus | ESCC | 8.29e-05 | 2.39e-01 | 0.0875 |
55795 | PCID2 | P2T-E | Human | Esophagus | ESCC | 6.70e-13 | 3.68e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007142713 | Thyroid | ATC | mRNA-containing ribonucleoprotein complex export from nucleus | 34/6293 | 59/18723 | 1.29e-04 | 9.10e-04 | 34 |
GO:005254834 | Thyroid | ATC | regulation of endopeptidase activity | 181/6293 | 432/18723 | 1.70e-04 | 1.16e-03 | 181 |
GO:000829811 | Thyroid | ATC | intracellular mRNA localization | 11/6293 | 13/18723 | 2.30e-04 | 1.49e-03 | 11 |
GO:007102711 | Thyroid | ATC | nuclear RNA surveillance | 11/6293 | 13/18723 | 2.30e-04 | 1.49e-03 | 11 |
GO:007102811 | Thyroid | ATC | nuclear mRNA surveillance | 11/6293 | 13/18723 | 2.30e-04 | 1.49e-03 | 11 |
GO:004586134 | Thyroid | ATC | negative regulation of proteolysis | 146/6293 | 351/18723 | 9.84e-04 | 5.22e-03 | 146 |
GO:005134629 | Thyroid | ATC | negative regulation of hydrolase activity | 155/6293 | 379/18723 | 1.64e-03 | 8.23e-03 | 155 |
GO:007102511 | Thyroid | ATC | RNA surveillance | 11/6293 | 15/18723 | 1.94e-03 | 9.41e-03 | 11 |
GO:1903706112 | Thyroid | ATC | regulation of hemopoiesis | 148/6293 | 367/18723 | 3.87e-03 | 1.68e-02 | 148 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCID2 | SNV | Missense_Mutation | c.509N>C | p.Arg170Pro | p.R170P | Q5JVF3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PCID2 | SNV | Missense_Mutation | rs750326771 | c.301A>G | p.Arg101Gly | p.R101G | Q5JVF3 | protein_coding | tolerated(0.09) | benign(0) | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PCID2 | SNV | Missense_Mutation | c.419N>T | p.Ser140Leu | p.S140L | Q5JVF3 | protein_coding | tolerated(0.44) | benign(0) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCID2 | SNV | Missense_Mutation | c.331G>C | p.Glu111Gln | p.E111Q | Q5JVF3 | protein_coding | tolerated(0.42) | benign(0) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
PCID2 | insertion | Nonsense_Mutation | novel | c.1295_1296insTCCCAAGTAGCTGGGAGCACAGGTGCATGCCACCACACCCA | p.His433ProfsTer3 | p.H433Pfs*3 | Q5JVF3 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PCID2 | insertion | In_Frame_Ins | novel | c.1027_1028insTACCACATTTCATCA | p.Gly343delinsValProHisPheIleSer | p.G343delinsVPHFIS | Q5JVF3 | protein_coding | TCGA-AN-A0FK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
PCID2 | SNV | Missense_Mutation | novel | c.814C>T | p.Arg272Cys | p.R272C | Q5JVF3 | protein_coding | deleterious(0.05) | possibly_damaging(0.854) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PCID2 | SNV | Missense_Mutation | rs768260894 | c.497C>T | p.Ala166Val | p.A166V | Q5JVF3 | protein_coding | tolerated(0.27) | benign(0.038) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PCID2 | SNV | Missense_Mutation | c.912N>A | p.Met304Ile | p.M304I | Q5JVF3 | protein_coding | deleterious(0.04) | benign(0.015) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PCID2 | SNV | Missense_Mutation | c.811N>A | p.Gly271Arg | p.G271R | Q5JVF3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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