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Gene: INS |
Gene summary for INS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | INS | Gene ID | 3630 |
| Gene name | insulin | |
| Gene Alias | IDDM | |
| Cytomap | 11p15.5 | |
| Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | I3WAC9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3630 | INS | HTA12-15-2 | Human | Pancreas | PDAC | 4.21e-07 | 6.33e-01 | 0.2315 |
| 3630 | INS | HTA12-16-5 | Human | Pancreas | PDAC | 1.34e-09 | 5.46e-01 | 0.047 |
| 3630 | INS | HTA12-29-1 | Human | Pancreas | PDAC | 1.10e-17 | 5.45e-01 | 0.3722 |
| 3630 | INS | HTA12-9-1 | Human | Pancreas | PDAC | 1.54e-02 | 3.32e-01 | 0.1532 |
| 3630 | INS | HTA12-9-2 | Human | Pancreas | PDAC | 3.02e-06 | -8.82e-01 | 0.0835 |
| 3630 | INS | 3829-EC | Human | Pancreas | PanIN | 3.51e-44 | 7.24e-01 | 0.009 |
| 3630 | INS | 4347-EC | Human | Pancreas | PanIN | 4.13e-187 | 1.20e+00 | 0.0572 |
| 3630 | INS | 4741-EC1 | Human | Pancreas | PanIN | 1.43e-45 | 8.66e-01 | 0.0223 |
| 3630 | INS | 181429 | Human | Pancreas | PDAC | 1.38e-04 | -1.64e+00 | 0.1416 |
| 3630 | INS | DS20191261Tumor | Human | Pancreas | PDAC | 1.19e-32 | -1.64e+00 | 0.1367 |
| 3630 | INS | DS20191261TumorKeller | Human | Pancreas | PDAC | 1.12e-06 | -1.64e+00 | 0.1407 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00620131 | Colorectum | FAP | positive regulation of small molecule metabolic process | 34/2622 | 143/18723 | 1.15e-03 | 1.10e-02 | 34 |
| GO:00336744 | Colorectum | FAP | positive regulation of kinase activity | 89/2622 | 467/18723 | 1.33e-03 | 1.22e-02 | 89 |
| GO:00316232 | Colorectum | FAP | receptor internalization | 28/2622 | 113/18723 | 1.56e-03 | 1.39e-02 | 28 |
| GO:19005421 | Colorectum | FAP | regulation of purine nucleotide metabolic process | 22/2622 | 84/18723 | 2.27e-03 | 1.84e-02 | 22 |
| GO:00454292 | Colorectum | FAP | positive regulation of nitric oxide biosynthetic process | 13/2622 | 40/18723 | 2.31e-03 | 1.86e-02 | 13 |
| GO:0046323 | Colorectum | FAP | glucose import | 20/2622 | 74/18723 | 2.36e-03 | 1.88e-02 | 20 |
| GO:00801642 | Colorectum | FAP | regulation of nitric oxide metabolic process | 18/2622 | 64/18723 | 2.37e-03 | 1.89e-02 | 18 |
| GO:0008286 | Colorectum | FAP | insulin receptor signaling pathway | 28/2622 | 116/18723 | 2.37e-03 | 1.89e-02 | 28 |
| GO:0043405 | Colorectum | FAP | regulation of MAP kinase activity | 39/2622 | 177/18723 | 2.38e-03 | 1.90e-02 | 39 |
| GO:0045821 | Colorectum | FAP | positive regulation of glycolytic process | 8/2622 | 19/18723 | 2.61e-03 | 2.03e-02 | 8 |
| GO:0045913 | Colorectum | FAP | positive regulation of carbohydrate metabolic process | 20/2622 | 75/18723 | 2.80e-03 | 2.15e-02 | 20 |
| GO:19044072 | Colorectum | FAP | positive regulation of nitric oxide metabolic process | 13/2622 | 41/18723 | 2.96e-03 | 2.25e-02 | 13 |
| GO:0006140 | Colorectum | FAP | regulation of nucleotide metabolic process | 22/2622 | 86/18723 | 3.11e-03 | 2.33e-02 | 22 |
| GO:00073462 | Colorectum | FAP | regulation of mitotic cell cycle | 85/2622 | 457/18723 | 3.41e-03 | 2.48e-02 | 85 |
| GO:00454282 | Colorectum | FAP | regulation of nitric oxide biosynthetic process | 17/2622 | 62/18723 | 4.12e-03 | 2.84e-02 | 17 |
| GO:00432442 | Colorectum | FAP | regulation of protein-containing complex disassembly | 28/2622 | 121/18723 | 4.50e-03 | 3.06e-02 | 28 |
| GO:00900681 | Colorectum | FAP | positive regulation of cell cycle process | 48/2622 | 236/18723 | 4.53e-03 | 3.08e-02 | 48 |
| GO:00970622 | Colorectum | FAP | dendritic spine maintenance | 8/2622 | 21/18723 | 5.43e-03 | 3.53e-02 | 8 |
| GO:0046324 | Colorectum | FAP | regulation of glucose import | 16/2622 | 59/18723 | 5.95e-03 | 3.75e-02 | 16 |
| GO:0002092 | Colorectum | FAP | positive regulation of receptor internalization | 9/2622 | 26/18723 | 6.73e-03 | 4.14e-02 | 9 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Breast | ADJ |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Breast | Healthy |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Breast | IDC |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Breast | Precancer |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Cervix | ADJ |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Cervix | Healthy |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Cervix | Precancer |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | ADJ |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | CRC |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | FAP |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | Healthy |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | MSI-H |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | MSS |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Endometrium | ADJ |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Endometrium | AEH |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Endometrium | EEC |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Endometrium | Healthy |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | Esophagus | ESCC |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | GC | ADJ |
| NAMPT | INSR | NAMPT_INSR | VISFATIN | GC | GC |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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