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Gene: IGFBP2 |
Gene summary for IGFBP2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | IGFBP2 | Gene ID | 3485 |
| Gene name | insulin like growth factor binding protein 2 | |
| Gene Alias | IBP2 | |
| Cytomap | 2q35 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P18065 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3485 | IGFBP2 | GSM4909281 | Human | Breast | IDC | 1.35e-11 | 3.23e-01 | 0.21 |
| 3485 | IGFBP2 | GSM4909293 | Human | Breast | IDC | 5.87e-95 | 1.29e+00 | 0.1581 |
| 3485 | IGFBP2 | GSM4909301 | Human | Breast | IDC | 1.10e-03 | 2.17e-01 | 0.1577 |
| 3485 | IGFBP2 | GSM4909303 | Human | Breast | IDC | 2.38e-06 | 4.93e-01 | 0.0438 |
| 3485 | IGFBP2 | GSM4909307 | Human | Breast | IDC | 2.28e-07 | 2.77e-01 | 0.1569 |
| 3485 | IGFBP2 | GSM4909308 | Human | Breast | IDC | 1.58e-04 | 2.05e-01 | 0.158 |
| 3485 | IGFBP2 | GSM4909316 | Human | Breast | IDC | 4.73e-08 | 6.75e-01 | 0.21 |
| 3485 | IGFBP2 | GSM4909319 | Human | Breast | IDC | 2.28e-07 | 5.55e-02 | 0.1563 |
| 3485 | IGFBP2 | GSM4909321 | Human | Breast | IDC | 8.62e-13 | 4.56e-01 | 0.1559 |
| 3485 | IGFBP2 | ctrl6 | Human | Breast | Precancer | 3.78e-14 | 6.46e-01 | -0.0061 |
| 3485 | IGFBP2 | NCCBC3 | Human | Breast | DCIS | 1.61e-02 | 2.63e-01 | 0.1198 |
| 3485 | IGFBP2 | NCCBC5 | Human | Breast | DCIS | 1.68e-03 | 3.42e-01 | 0.2046 |
| 3485 | IGFBP2 | P3 | Human | Breast | IDC | 6.53e-05 | 6.65e-01 | 0.1542 |
| 3485 | IGFBP2 | DCIS2 | Human | Breast | DCIS | 5.83e-06 | -8.19e-02 | 0.0085 |
| 3485 | IGFBP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.03e-08 | 4.26e-01 | 0.0155 |
| 3485 | IGFBP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.04e-06 | 5.72e-01 | -0.1808 |
| 3485 | IGFBP2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.76e-02 | 7.79e-01 | 0.0216 |
| 3485 | IGFBP2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.89e-30 | 1.27e+00 | -0.0811 |
| 3485 | IGFBP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.97e-27 | 1.03e+00 | -0.1088 |
| 3485 | IGFBP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.77e-04 | 4.32e-01 | -0.1954 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0043567 | Skin | AK | regulation of insulin-like growth factor receptor signaling pathway | 7/1910 | 24/18723 | 8.26e-03 | 4.13e-02 | 7 |
| GO:004854529 | Skin | cSCC | response to steroid hormone | 135/4864 | 339/18723 | 1.34e-08 | 4.09e-07 | 135 |
| GO:000756827 | Skin | cSCC | aging | 127/4864 | 339/18723 | 1.80e-06 | 3.02e-05 | 127 |
| GO:001605524 | Skin | cSCC | Wnt signaling pathway | 158/4864 | 444/18723 | 3.80e-06 | 5.70e-05 | 158 |
| GO:019873824 | Skin | cSCC | cell-cell signaling by wnt | 158/4864 | 446/18723 | 5.08e-06 | 7.38e-05 | 158 |
| GO:001003829 | Skin | cSCC | response to metal ion | 132/4864 | 373/18723 | 3.11e-05 | 3.42e-04 | 132 |
| GO:003011124 | Skin | cSCC | regulation of Wnt signaling pathway | 117/4864 | 328/18723 | 5.80e-05 | 5.75e-04 | 117 |
| GO:003166728 | Skin | cSCC | response to nutrient levels | 160/4864 | 474/18723 | 8.44e-05 | 8.02e-04 | 160 |
| GO:0051384110 | Skin | cSCC | response to glucocorticoid | 57/4864 | 148/18723 | 5.30e-04 | 3.97e-03 | 57 |
| GO:0031960110 | Skin | cSCC | response to corticosteroid | 63/4864 | 167/18723 | 5.35e-04 | 3.97e-03 | 63 |
| GO:0009410110 | Skin | cSCC | response to xenobiotic stimulus | 151/4864 | 462/18723 | 6.76e-04 | 4.82e-03 | 151 |
| GO:006007024 | Skin | cSCC | canonical Wnt signaling pathway | 104/4864 | 303/18723 | 7.13e-04 | 5.03e-03 | 104 |
| GO:006082824 | Skin | cSCC | regulation of canonical Wnt signaling pathway | 87/4864 | 253/18723 | 1.74e-03 | 1.06e-02 | 87 |
| GO:000758416 | Skin | cSCC | response to nutrient | 63/4864 | 174/18723 | 1.78e-03 | 1.08e-02 | 63 |
| GO:004578529 | Skin | cSCC | positive regulation of cell adhesion | 139/4864 | 437/18723 | 3.39e-03 | 1.84e-02 | 139 |
| GO:000961224 | Skin | cSCC | response to mechanical stimulus | 73/4864 | 216/18723 | 6.22e-03 | 3.04e-02 | 73 |
| GO:003235523 | Skin | cSCC | response to estradiol | 50/4864 | 141/18723 | 7.85e-03 | 3.65e-02 | 50 |
| GO:00094106 | Stomach | GC | response to xenobiotic stimulus | 61/1159 | 462/18723 | 1.68e-08 | 1.43e-06 | 61 |
| GO:00100386 | Stomach | GC | response to metal ion | 52/1159 | 373/18723 | 3.24e-08 | 2.44e-06 | 52 |
| GO:0031960 | Stomach | GC | response to corticosteroid | 30/1159 | 167/18723 | 1.18e-07 | 7.16e-06 | 30 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| IGFBP2 | SNV | Missense_Mutation | c.871N>A | p.Gly291Arg | p.G291R | P18065 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| IGFBP2 | SNV | Missense_Mutation | c.751G>A | p.Glu251Lys | p.E251K | P18065 | protein_coding | deleterious(0) | possibly_damaging(0.845) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| IGFBP2 | SNV | Missense_Mutation | c.797N>C | p.Leu266Pro | p.L266P | P18065 | protein_coding | tolerated(0.07) | probably_damaging(0.927) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| IGFBP2 | SNV | Missense_Mutation | c.961N>G | p.Thr321Ala | p.T321A | P18065 | protein_coding | tolerated_low_confidence(0.56) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| IGFBP2 | SNV | Missense_Mutation | novel | c.530N>A | p.Gly177Asp | p.G177D | P18065 | protein_coding | tolerated(0.33) | benign(0.07) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| IGFBP2 | SNV | Missense_Mutation | c.577N>A | p.Glu193Lys | p.E193K | P18065 | protein_coding | tolerated(0.06) | possibly_damaging(0.604) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| IGFBP2 | SNV | Missense_Mutation | novel | c.463G>A | p.Glu155Lys | p.E155K | P18065 | protein_coding | tolerated(0.05) | benign(0.294) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| IGFBP2 | SNV | Missense_Mutation | novel | c.500N>C | p.Met167Thr | p.M167T | P18065 | protein_coding | tolerated(0.77) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| IGFBP2 | SNV | Missense_Mutation | c.838N>T | p.Arg280Cys | p.R280C | P18065 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BS-A0UA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| IGFBP2 | SNV | Missense_Mutation | rs774149508 | c.725N>A | p.Arg242His | p.R242H | P18065 | protein_coding | tolerated(0.06) | benign(0.029) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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