Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/DNAJB1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/DNAJB1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/DNAJB1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/DNAJB1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/DNAJB1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/DNAJB1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/DNAJB1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/DNAJB1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/DNAJB1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/DNAJB1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/DNAJB1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/DNAJB1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003596631 | Stomach | CAG | response to topologically incorrect protein | 24/552 | 159/18723 | 4.91e-11 | 1.69e-08 | 24 |
GO:000645831 | Stomach | CAG | 'de novo' protein folding | 13/552 | 43/18723 | 1.80e-10 | 5.73e-08 | 13 |
GO:005108531 | Stomach | CAG | chaperone cofactor-dependent protein refolding | 11/552 | 34/18723 | 2.05e-09 | 3.66e-07 | 11 |
GO:005108431 | Stomach | CAG | 'de novo' posttranslational protein folding | 11/552 | 39/18723 | 1.05e-08 | 1.38e-06 | 11 |
GO:00436183 | Stomach | CAG | regulation of transcription from RNA polymerase II promoter in response to stress | 10/552 | 47/18723 | 8.87e-07 | 5.91e-05 | 10 |
GO:00092663 | Stomach | CAG | response to temperature stimulus | 19/552 | 178/18723 | 1.38e-06 | 8.67e-05 | 19 |
GO:004362031 | Stomach | CAG | regulation of DNA-templated transcription in response to stress | 10/552 | 53/18723 | 2.85e-06 | 1.46e-04 | 10 |
GO:00972013 | Stomach | CAG | negative regulation of transcription from RNA polymerase II promoter in response to stress | 5/552 | 12/18723 | 1.46e-05 | 5.69e-04 | 5 |
GO:00094083 | Stomach | CAG | response to heat | 13/552 | 110/18723 | 2.15e-05 | 7.85e-04 | 13 |
GO:003460531 | Stomach | CAG | cellular response to heat | 10/552 | 69/18723 | 3.26e-05 | 1.09e-03 | 10 |
GO:00708413 | Stomach | CAG | inclusion body assembly | 6/552 | 24/18723 | 5.47e-05 | 1.60e-03 | 6 |
GO:00900833 | Stomach | CAG | regulation of inclusion body assembly | 5/552 | 17/18723 | 1.01e-04 | 2.63e-03 | 5 |
GO:00900843 | Stomach | CAG | negative regulation of inclusion body assembly | 4/552 | 11/18723 | 2.09e-04 | 4.32e-03 | 4 |
GO:000645741 | Stomach | WIM | protein folding | 28/426 | 212/18723 | 6.19e-14 | 8.17e-11 | 28 |
GO:00069864 | Stomach | WIM | response to unfolded protein | 22/426 | 137/18723 | 5.76e-13 | 5.71e-10 | 22 |
GO:00359664 | Stomach | WIM | response to topologically incorrect protein | 22/426 | 159/18723 | 1.25e-11 | 8.26e-09 | 22 |
GO:00510854 | Stomach | WIM | chaperone cofactor-dependent protein refolding | 11/426 | 34/18723 | 1.33e-10 | 5.89e-08 | 11 |
GO:00064584 | Stomach | WIM | 'de novo' protein folding | 12/426 | 43/18723 | 1.34e-10 | 5.89e-08 | 12 |
GO:00610774 | Stomach | WIM | chaperone-mediated protein folding | 14/426 | 67/18723 | 2.63e-10 | 1.04e-07 | 14 |
GO:00510844 | Stomach | WIM | 'de novo' posttranslational protein folding | 11/426 | 39/18723 | 7.03e-10 | 1.74e-07 | 11 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0516414 | Cervix | CC | Influenza A | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0516415 | Cervix | CC | Influenza A | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0516422 | Cervix | HSIL_HPV | Influenza A | 23/459 | 171/8465 | 4.65e-05 | 6.48e-04 | 5.24e-04 | 23 |
hsa0516432 | Cervix | HSIL_HPV | Influenza A | 23/459 | 171/8465 | 4.65e-05 | 6.48e-04 | 5.24e-04 | 23 |
hsa0414144 | Cervix | N_HPV | Protein processing in endoplasmic reticulum | 21/349 | 174/8465 | 8.84e-06 | 1.09e-04 | 8.55e-05 | 21 |
hsa0516441 | Cervix | N_HPV | Influenza A | 16/349 | 171/8465 | 1.81e-03 | 1.12e-02 | 8.75e-03 | 16 |
hsa0414154 | Cervix | N_HPV | Protein processing in endoplasmic reticulum | 21/349 | 174/8465 | 8.84e-06 | 1.09e-04 | 8.55e-05 | 21 |
hsa0516451 | Cervix | N_HPV | Influenza A | 16/349 | 171/8465 | 1.81e-03 | 1.12e-02 | 8.75e-03 | 16 |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJB1 | SNV | Missense_Mutation | | c.148N>C | p.Glu50Gln | p.E50Q | P25685 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
DNAJB1 | SNV | Missense_Mutation | | c.514C>A | p.Leu172Ile | p.L172I | P25685 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-D8-A1JC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
DNAJB1 | insertion | Frame_Shift_Ins | novel | c.387_388insAGTTTCCAGGTGTCTTG | p.Pro130SerfsTer21 | p.P130Sfs*21 | P25685 | protein_coding | | | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNAJB1 | SNV | Missense_Mutation | rs768130288 | c.52N>A | p.Glu18Lys | p.E18K | P25685 | protein_coding | deleterious(0.04) | benign(0.16) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
DNAJB1 | SNV | Missense_Mutation | | c.746G>A | p.Arg249Lys | p.R249K | P25685 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
DNAJB1 | insertion | Frame_Shift_Ins | novel | c.612_613insGGGTCTC | p.Thr205GlyfsTer32 | p.T205Gfs*32 | P25685 | protein_coding | | | TCGA-C5-A2LY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
DNAJB1 | insertion | Nonsense_Mutation | novel | c.610_611insCCTGATTTTTTTTTTTTAA | p.Leu204SerfsTer2 | p.L204Sfs*2 | P25685 | protein_coding | | | TCGA-C5-A2LY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
DNAJB1 | SNV | Missense_Mutation | novel | c.419N>A | p.Gly140Asp | p.G140D | P25685 | protein_coding | tolerated(0.05) | possibly_damaging(0.901) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAJB1 | SNV | Missense_Mutation | | c.210N>C | p.Glu70Asp | p.E70D | P25685 | protein_coding | tolerated(0.14) | benign(0.076) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DNAJB1 | insertion | Frame_Shift_Ins | novel | c.581_582insCCATCTCTCTT | p.Lys195HisfsTer4 | p.K195Hfs*4 | P25685 | protein_coding | | | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |