Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/CIRBP_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/CIRBP_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CIRBP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CIRBP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CIRBP_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CIRBP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CIRBP_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CIRBP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CIRBP_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CIRBP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CIRBP_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CIRBP_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CIRBP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190237311 | Liver | HCC | negative regulation of mRNA catabolic process | 37/7958 | 63/18723 | 6.82e-03 | 2.73e-02 | 37 |
GO:004825511 | Liver | HCC | mRNA stabilization | 33/7958 | 56/18723 | 9.64e-03 | 3.63e-02 | 33 |
GO:004348432 | Liver | Cyst | regulation of RNA splicing | 20/496 | 148/18723 | 2.35e-09 | 4.36e-07 | 20 |
GO:004802431 | Liver | Cyst | regulation of mRNA splicing, via spliceosome | 15/496 | 101/18723 | 6.62e-08 | 8.56e-06 | 15 |
GO:000037732 | Liver | Cyst | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 26/496 | 320/18723 | 4.57e-07 | 4.77e-05 | 26 |
GO:000039832 | Liver | Cyst | mRNA splicing, via spliceosome | 26/496 | 320/18723 | 4.57e-07 | 4.77e-05 | 26 |
GO:000037532 | Liver | Cyst | RNA splicing, via transesterification reactions | 26/496 | 324/18723 | 5.80e-07 | 5.76e-05 | 26 |
GO:000838032 | Liver | Cyst | RNA splicing | 31/496 | 434/18723 | 6.22e-07 | 6.04e-05 | 31 |
GO:005068431 | Liver | Cyst | regulation of mRNA processing | 16/496 | 137/18723 | 7.19e-07 | 6.82e-05 | 16 |
GO:190331131 | Liver | Cyst | regulation of mRNA metabolic process | 22/496 | 288/18723 | 9.42e-06 | 6.49e-04 | 22 |
GO:000641732 | Liver | Cyst | regulation of translation | 28/496 | 468/18723 | 5.69e-05 | 3.00e-03 | 28 |
GO:004572722 | Liver | Cyst | positive regulation of translation | 13/496 | 136/18723 | 6.75e-05 | 3.39e-03 | 13 |
GO:190331232 | Liver | Cyst | negative regulation of mRNA metabolic process | 10/496 | 92/18723 | 1.61e-04 | 6.53e-03 | 10 |
GO:003425032 | Liver | Cyst | positive regulation of cellular amide metabolic process | 13/496 | 162/18723 | 3.89e-04 | 1.21e-02 | 13 |
GO:003133032 | Liver | Cyst | negative regulation of cellular catabolic process | 16/496 | 262/18723 | 1.75e-03 | 3.87e-02 | 16 |
GO:000989532 | Liver | Cyst | negative regulation of catabolic process | 18/496 | 320/18723 | 2.31e-03 | 4.60e-02 | 18 |
GO:004802622 | Liver | Cyst | positive regulation of mRNA splicing, via spliceosome | 4/496 | 22/18723 | 2.44e-03 | 4.77e-02 | 4 |
GO:00434848 | Lung | IAC | regulation of RNA splicing | 49/2061 | 148/18723 | 4.76e-13 | 7.06e-10 | 49 |
GO:19033117 | Lung | IAC | regulation of mRNA metabolic process | 71/2061 | 288/18723 | 3.76e-11 | 1.24e-08 | 71 |
GO:00480248 | Lung | IAC | regulation of mRNA splicing, via spliceosome | 34/2061 | 101/18723 | 1.05e-09 | 1.95e-07 | 34 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CIRBP | SNV | Missense_Mutation | | c.820N>A | p.Val274Met | p.V274M | | protein_coding | tolerated_low_confidence(0.09) | benign(0.017) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
CIRBP | SNV | Missense_Mutation | rs749046630 | c.493N>A | p.Asp165Asn | p.D165N | | protein_coding | deleterious(0) | possibly_damaging(0.632) | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
CIRBP | SNV | Missense_Mutation | rs148277498 | c.791N>A | p.Arg264His | p.R264H | | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-E2-A14Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD |
CIRBP | SNV | Missense_Mutation | | c.758C>G | p.Ser253Cys | p.S253C | | protein_coding | tolerated_low_confidence(0.06) | benign(0.146) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
CIRBP | SNV | Missense_Mutation | | c.80C>T | p.Ser27Leu | p.S27L | | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CIRBP | SNV | Missense_Mutation | novel | c.643C>G | p.Gln215Glu | p.Q215E | | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CIRBP | SNV | Missense_Mutation | | c.98N>T | p.Ser33Phe | p.S33F | | protein_coding | deleterious(0.04) | probably_damaging(0.986) | TCGA-EA-A3HQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CIRBP | SNV | Missense_Mutation | | c.731N>A | p.Arg244Lys | p.R244K | | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
CIRBP | SNV | Missense_Mutation | rs11555031 | c.49N>G | p.Thr17Ala | p.T17A | | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CIRBP | SNV | Missense_Mutation | | c.5N>T | p.Ala2Val | p.A2V | | protein_coding | deleterious(0) | possibly_damaging(0.526) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |