Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CHCHD10

Gene summary for CHCHD10

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CHCHD10

Gene ID

400916

Gene namecoiled-coil-helix-coiled-coil-helix domain containing 10
Gene AliasC22orf16
Cytomap22q11.23
Gene Typeprotein-coding
GO ID

GO:0000959

UniProtAcc

B5MBW9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
400916CHCHD10CA_HPV_1HumanCervixCC9.81e-077.06e-020.0264
400916CHCHD10CCI_1HumanCervixCC2.17e-08-6.65e-010.528
400916CHCHD10CCI_3HumanCervixCC2.01e-06-5.70e-010.516
400916CHCHD10CCII_1HumanCervixCC2.75e-22-7.06e-010.3249
400916CHCHD10sample1HumanCervixCC5.48e-094.31e-010.0959
400916CHCHD10L1HumanCervixCC3.16e-11-4.45e-010.0802
400916CHCHD10T1HumanCervixCC9.13e-052.93e-010.0918
400916CHCHD10HTA11_2487_2000001011HumanColorectumSER5.86e-261.06e+00-0.1808
400916CHCHD10HTA11_1938_2000001011HumanColorectumAD2.49e-097.25e-01-0.0811
400916CHCHD10HTA11_78_2000001011HumanColorectumAD1.55e-064.68e-01-0.1088
400916CHCHD10HTA11_347_2000001011HumanColorectumAD9.05e-411.18e+00-0.1954
400916CHCHD10HTA11_411_2000001011HumanColorectumSER1.42e-071.07e+00-0.2602
400916CHCHD10HTA11_3361_2000001011HumanColorectumAD1.20e-231.07e+00-0.1207
400916CHCHD10HTA11_83_2000001011HumanColorectumSER2.91e-118.33e-01-0.1526
400916CHCHD10HTA11_696_2000001011HumanColorectumAD3.29e-389.67e-01-0.1464
400916CHCHD10HTA11_866_2000001011HumanColorectumAD6.06e-207.19e-01-0.1001
400916CHCHD10HTA11_1391_2000001011HumanColorectumAD2.04e-168.04e-01-0.059
400916CHCHD10HTA11_2992_2000001011HumanColorectumSER3.21e-109.43e-01-0.1706
400916CHCHD10HTA11_5212_2000001011HumanColorectumAD9.91e-078.30e-01-0.2061
400916CHCHD10HTA11_5216_2000001011HumanColorectumSER3.52e-036.91e-01-0.1462
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:19026863StomachCAGmitochondrial outer membrane permeabilization involved in programmed cell death5/55240/187236.14e-034.88e-025
GO:004603451StomachSIMATP metabolic process48/708277/187236.21e-191.46e-1548
GO:00061195StomachSIMoxidative phosphorylation31/708141/187231.21e-157.15e-1331
GO:000609151StomachSIMgeneration of precursor metabolites and energy58/708490/187231.10e-145.18e-1258
GO:00090605StomachSIMaerobic respiration32/708189/187239.30e-133.37e-1032
GO:00453335StomachSIMcellular respiration34/708230/187239.47e-123.19e-0934
GO:00159805StomachSIMenergy derivation by oxidation of organic compounds40/708318/187232.55e-117.53e-0940
GO:00086375StomachSIMapoptotic mitochondrial changes18/708107/187231.00e-078.64e-0618
GO:00512355StomachSIMmaintenance of location29/708327/187232.01e-056.37e-0429
GO:00108214StomachSIMregulation of mitochondrion organization16/708144/187231.13e-042.68e-0316
GO:00516515StomachSIMmaintenance of location in cell20/708214/187231.88e-043.97e-0320
GO:00068395StomachSIMmitochondrial transport22/708254/187232.74e-045.21e-0322
GO:00451855StomachSIMmaintenance of protein location11/70894/187238.33e-041.14e-0211
GO:003250721StomachSIMmaintenance of protein location in cell8/70865/187233.03e-032.92e-028
GO:000700631StomachSIMmitochondrial membrane organization11/708116/187234.50e-033.94e-0211
GO:00725952StomachSIMmaintenance of protein localization in organelle6/70842/187234.70e-034.08e-026
GO:0009060112ThyroidPTCaerobic respiration126/5968189/187237.07e-231.78e-20126
GO:0046034113ThyroidPTCATP metabolic process167/5968277/187231.18e-222.66e-20167
GO:0034504111ThyroidPTCprotein localization to nucleus170/5968290/187233.34e-216.38e-19170
GO:0006091112ThyroidPTCgeneration of precursor metabolites and energy252/5968490/187238.24e-201.13e-17252
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501418CervixCCAmyotrophic lateral sclerosis103/1267364/84651.79e-114.47e-102.64e-10103
hsa0501419CervixCCAmyotrophic lateral sclerosis103/1267364/84651.79e-114.47e-102.64e-10103
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa050141ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa050142ColorectumSERAmyotrophic lateral sclerosis138/1580364/84659.89e-192.99e-172.17e-17138
hsa050143ColorectumSERAmyotrophic lateral sclerosis138/1580364/84659.89e-192.99e-172.17e-17138
hsa050144ColorectumMSSAmyotrophic lateral sclerosis156/1875364/84651.43e-194.62e-182.83e-18156
hsa050145ColorectumMSSAmyotrophic lateral sclerosis156/1875364/84651.43e-194.62e-182.83e-18156
hsa050148ColorectumFAPAmyotrophic lateral sclerosis91/1404364/84651.84e-052.36e-041.44e-0491
hsa050149ColorectumFAPAmyotrophic lateral sclerosis91/1404364/84651.84e-052.36e-041.44e-0491
hsa0501420EndometriumAEHAmyotrophic lateral sclerosis123/1197364/84652.17e-227.82e-215.72e-21123
hsa05014110EndometriumAEHAmyotrophic lateral sclerosis123/1197364/84652.17e-227.82e-215.72e-21123
hsa0501425EndometriumEECAmyotrophic lateral sclerosis128/1237364/84659.83e-244.04e-223.01e-22128
hsa0501435EndometriumEECAmyotrophic lateral sclerosis128/1237364/84659.83e-244.04e-223.01e-22128
hsa0501430EsophagusHGINAmyotrophic lateral sclerosis140/1383364/84652.13e-251.16e-239.19e-24140
hsa05014113EsophagusHGINAmyotrophic lateral sclerosis140/1383364/84652.13e-251.16e-239.19e-24140
hsa05014210EsophagusESCCAmyotrophic lateral sclerosis266/4205364/84651.31e-202.20e-181.13e-18266
hsa0501438EsophagusESCCAmyotrophic lateral sclerosis266/4205364/84651.31e-202.20e-181.13e-18266
hsa0501414LiverCirrhoticAmyotrophic lateral sclerosis187/2530364/84651.56e-186.50e-174.01e-17187
hsa0501415LiverCirrhoticAmyotrophic lateral sclerosis187/2530364/84651.56e-186.50e-174.01e-17187
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CHCHD10SNVMissense_Mutationrs562212051c.328N>Ap.Ala110Thrp.A110Tprotein_codingtolerated(0.41)benign(0.307)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
CHCHD10SNVMissense_Mutationnovelc.402N>Tp.Glu134Aspp.E134Dprotein_codingdeleterious(0.04)probably_damaging(0.994)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
CHCHD10SNVMissense_Mutationnovelc.173N>Tp.Gly58Valp.G58Vprotein_codingdeleterious(0)probably_damaging(0.999)TCGA-DD-AACI-01Liverliver hepatocellular carcinomaMale>=65I/IIUnknownUnknownPD
CHCHD10SNVMissense_Mutationc.427N>Ap.His143Asnp.H143Nprotein_codingtolerated(1)benign(0.003)TCGA-66-2734-01Lunglung squamous cell carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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