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Gene: ATP5F1D |
Gene summary for ATP5F1D |
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Gene information | Species | Human | Gene symbol | ATP5F1D | Gene ID | 513 |
Gene name | ATP synthase F1 subunit delta | |
Gene Alias | ATP5D | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P30049 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
513 | ATP5F1D | GSM4909285 | Human | Breast | IDC | 5.17e-11 | 1.44e-01 | 0.21 |
513 | ATP5F1D | GSM4909286 | Human | Breast | IDC | 2.37e-19 | 1.31e-02 | 0.1081 |
513 | ATP5F1D | GSM4909290 | Human | Breast | IDC | 3.46e-04 | 1.46e-01 | 0.2096 |
513 | ATP5F1D | GSM4909291 | Human | Breast | IDC | 8.76e-10 | 4.79e-01 | 0.1753 |
513 | ATP5F1D | GSM4909293 | Human | Breast | IDC | 2.10e-10 | 1.11e-01 | 0.1581 |
513 | ATP5F1D | GSM4909296 | Human | Breast | IDC | 1.94e-09 | -4.02e-01 | 0.1524 |
513 | ATP5F1D | GSM4909297 | Human | Breast | IDC | 5.92e-06 | -1.30e-02 | 0.1517 |
513 | ATP5F1D | GSM4909298 | Human | Breast | IDC | 2.43e-13 | 3.46e-01 | 0.1551 |
513 | ATP5F1D | GSM4909299 | Human | Breast | IDC | 2.02e-02 | 2.23e-01 | 0.035 |
513 | ATP5F1D | GSM4909301 | Human | Breast | IDC | 1.26e-02 | 3.05e-01 | 0.1577 |
513 | ATP5F1D | GSM4909302 | Human | Breast | IDC | 7.25e-05 | 3.64e-01 | 0.1545 |
513 | ATP5F1D | GSM4909303 | Human | Breast | IDC | 2.40e-05 | 4.28e-01 | 0.0438 |
513 | ATP5F1D | GSM4909304 | Human | Breast | IDC | 2.15e-26 | 6.47e-01 | 0.1636 |
513 | ATP5F1D | GSM4909305 | Human | Breast | IDC | 1.20e-17 | 3.88e-01 | 0.0436 |
513 | ATP5F1D | GSM4909306 | Human | Breast | IDC | 7.51e-07 | 3.51e-01 | 0.1564 |
513 | ATP5F1D | GSM4909308 | Human | Breast | IDC | 9.05e-29 | 4.72e-01 | 0.158 |
513 | ATP5F1D | GSM4909311 | Human | Breast | IDC | 5.87e-29 | -5.14e-02 | 0.1534 |
513 | ATP5F1D | GSM4909317 | Human | Breast | IDC | 5.07e-19 | 3.70e-01 | 0.1355 |
513 | ATP5F1D | GSM4909318 | Human | Breast | IDC | 3.67e-05 | 6.50e-01 | 0.2031 |
513 | ATP5F1D | GSM4909319 | Human | Breast | IDC | 6.74e-39 | -2.27e-01 | 0.1563 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000914122 | Lung | AAH | nucleoside triphosphate metabolic process | 12/613 | 112/18723 | 3.05e-04 | 1.45e-02 | 12 |
GO:00061198 | Lung | AAH | oxidative phosphorylation | 13/613 | 141/18723 | 7.49e-04 | 2.63e-02 | 13 |
GO:000915222 | Lung | AAH | purine ribonucleotide biosynthetic process | 14/613 | 169/18723 | 1.36e-03 | 3.62e-02 | 14 |
GO:001598522 | Lung | AAH | energy coupled proton transport, down electrochemical gradient | 5/613 | 26/18723 | 1.38e-03 | 3.62e-02 | 5 |
GO:001598622 | Lung | AAH | ATP synthesis coupled proton transport | 5/613 | 26/18723 | 1.38e-03 | 3.62e-02 | 5 |
GO:004603418 | Prostate | BPH | ATP metabolic process | 120/3107 | 277/18723 | 4.78e-26 | 1.48e-22 | 120 |
GO:000611917 | Prostate | BPH | oxidative phosphorylation | 77/3107 | 141/18723 | 5.53e-25 | 1.14e-21 | 77 |
GO:000906016 | Prostate | BPH | aerobic respiration | 86/3107 | 189/18723 | 9.81e-21 | 1.01e-17 | 86 |
GO:000609116 | Prostate | BPH | generation of precursor metabolites and energy | 161/3107 | 490/18723 | 3.05e-19 | 1.45e-16 | 161 |
GO:001598016 | Prostate | BPH | energy derivation by oxidation of organic compounds | 115/3107 | 318/18723 | 1.55e-17 | 4.36e-15 | 115 |
GO:004533316 | Prostate | BPH | cellular respiration | 92/3107 | 230/18723 | 1.67e-17 | 4.49e-15 | 92 |
GO:000915018 | Prostate | BPH | purine ribonucleotide metabolic process | 107/3107 | 368/18723 | 1.18e-09 | 5.19e-08 | 107 |
GO:000914417 | Prostate | BPH | purine nucleoside triphosphate metabolic process | 38/3107 | 88/18723 | 3.68e-09 | 1.41e-07 | 38 |
GO:000920510 | Prostate | BPH | purine ribonucleoside triphosphate metabolic process | 36/3107 | 82/18723 | 5.49e-09 | 1.99e-07 | 36 |
GO:000683916 | Prostate | BPH | mitochondrial transport | 79/3107 | 254/18723 | 6.77e-09 | 2.38e-07 | 79 |
GO:000925917 | Prostate | BPH | ribonucleotide metabolic process | 108/3107 | 385/18723 | 8.73e-09 | 2.97e-07 | 108 |
GO:000616318 | Prostate | BPH | purine nucleotide metabolic process | 109/3107 | 396/18723 | 2.28e-08 | 6.94e-07 | 109 |
GO:001969317 | Prostate | BPH | ribose phosphate metabolic process | 109/3107 | 396/18723 | 2.28e-08 | 6.94e-07 | 109 |
GO:001003818 | Prostate | BPH | response to metal ion | 104/3107 | 373/18723 | 2.32e-08 | 6.99e-07 | 104 |
GO:007252118 | Prostate | BPH | purine-containing compound metabolic process | 113/3107 | 416/18723 | 2.77e-08 | 8.13e-07 | 113 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
513 | ATP5F1D | TRANSPORTER | ENFLURANE | ENFLURANE | ||
513 | ATP5F1D | TRANSPORTER | DESFLURANE | DESFLURANE | ||
513 | ATP5F1D | TRANSPORTER | METHOXYFLURANE | METHOXYFLURANE | ||
513 | ATP5F1D | TRANSPORTER | METHOXYFLURANE | METHOXYFLURANE | ||
513 | ATP5F1D | TRANSPORTER | HALOTHANE | HALOTHANE | ||
513 | ATP5F1D | TRANSPORTER | DESFLURANE | DESFLURANE | ||
513 | ATP5F1D | TRANSPORTER | HALOTHANE | HALOTHANE | ||
513 | ATP5F1D | TRANSPORTER | SEVOFLURANE | SEVOFLURANE | ||
513 | ATP5F1D | TRANSPORTER | SEVOFLURANE | SEVOFLURANE | ||
513 | ATP5F1D | TRANSPORTER | ENFLURANE | ENFLURANE |
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