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Gene: AHCY |
Gene summary for AHCY |
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Gene information | Species | Human | Gene symbol | AHCY | Gene ID | 191 |
Gene name | adenosylhomocysteinase | |
Gene Alias | SAHH | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0001666 | UniProtAcc | P23526 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
191 | AHCY | HTA11_78_2000001011 | Human | Colorectum | AD | 1.20e-02 | 2.67e-01 | -0.1088 |
191 | AHCY | HTA11_347_2000001011 | Human | Colorectum | AD | 6.59e-03 | 2.05e-01 | -0.1954 |
191 | AHCY | HTA11_696_2000001011 | Human | Colorectum | AD | 1.88e-03 | 2.34e-01 | -0.1464 |
191 | AHCY | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.25e-08 | 4.78e-01 | -0.059 |
191 | AHCY | HTA11_866_3004761011 | Human | Colorectum | AD | 2.90e-15 | 5.50e-01 | 0.096 |
191 | AHCY | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.12e-07 | 5.66e-01 | 0.0446 |
191 | AHCY | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.72e-06 | 3.59e-01 | 0.0674 |
191 | AHCY | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.00e-07 | 4.04e-01 | 0.0588 |
191 | AHCY | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.44e-08 | 4.69e-01 | 0.281 |
191 | AHCY | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.41e-62 | 1.51e+00 | 0.3859 |
191 | AHCY | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.61e-15 | 7.03e-01 | 0.2585 |
191 | AHCY | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.09e-32 | 7.77e-01 | 0.3005 |
191 | AHCY | LZE4T | Human | Esophagus | ESCC | 8.06e-17 | 9.29e-01 | 0.0811 |
191 | AHCY | LZE5T | Human | Esophagus | ESCC | 9.53e-03 | 6.27e-01 | 0.0514 |
191 | AHCY | LZE7T | Human | Esophagus | ESCC | 7.48e-13 | 1.03e+00 | 0.0667 |
191 | AHCY | LZE8T | Human | Esophagus | ESCC | 2.15e-14 | 7.65e-01 | 0.067 |
191 | AHCY | LZE20T | Human | Esophagus | ESCC | 2.91e-03 | 3.65e-01 | 0.0662 |
191 | AHCY | LZE22D1 | Human | Esophagus | HGIN | 1.80e-03 | 3.64e-01 | 0.0595 |
191 | AHCY | LZE22T | Human | Esophagus | ESCC | 3.93e-05 | 9.94e-01 | 0.068 |
191 | AHCY | LZE24T | Human | Esophagus | ESCC | 2.90e-36 | 2.09e+00 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003112413 | Thyroid | ATC | mRNA 3'-end processing | 40/6293 | 62/18723 | 6.25e-07 | 8.65e-06 | 40 |
GO:002240622 | Thyroid | ATC | membrane docking | 49/6293 | 86/18723 | 7.13e-06 | 7.34e-05 | 49 |
GO:003144014 | Thyroid | ATC | regulation of mRNA 3'-end processing | 21/6293 | 28/18723 | 8.94e-06 | 8.95e-05 | 21 |
GO:0010038210 | Thyroid | ATC | response to metal ion | 165/6293 | 373/18723 | 1.07e-05 | 1.05e-04 | 165 |
GO:000762325 | Thyroid | ATC | circadian rhythm | 100/6293 | 210/18723 | 1.67e-05 | 1.54e-04 | 100 |
GO:004363112 | Thyroid | ATC | RNA polyadenylation | 29/6293 | 45/18723 | 2.26e-05 | 2.00e-04 | 29 |
GO:000637812 | Thyroid | ATC | mRNA polyadenylation | 28/6293 | 44/18723 | 4.39e-05 | 3.54e-04 | 28 |
GO:014005613 | Thyroid | ATC | organelle localization by membrane tethering | 41/6293 | 77/18723 | 2.97e-04 | 1.88e-03 | 41 |
GO:005159225 | Thyroid | ATC | response to calcium ion | 69/6293 | 149/18723 | 8.43e-04 | 4.62e-03 | 69 |
GO:000758418 | Thyroid | ATC | response to nutrient | 78/6293 | 174/18723 | 1.31e-03 | 6.85e-03 | 78 |
GO:000657522 | Thyroid | ATC | cellular modified amino acid metabolic process | 82/6293 | 188/18723 | 2.60e-03 | 1.20e-02 | 82 |
GO:19011363 | Thyroid | ATC | carbohydrate derivative catabolic process | 73/6293 | 172/18723 | 9.43e-03 | 3.47e-02 | 73 |
GO:00725232 | Thyroid | ATC | purine-containing compound catabolic process | 26/6293 | 52/18723 | 1.05e-02 | 3.82e-02 | 26 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00270 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002701 | Liver | Cirrhotic | Cysteine and methionine metabolism | 27/2530 | 52/8465 | 6.98e-04 | 4.15e-03 | 2.56e-03 | 27 |
hsa002702 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
hsa002703 | Liver | HCC | Cysteine and methionine metabolism | 35/4020 | 52/8465 | 3.03e-03 | 9.94e-03 | 5.53e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AHCY | SNV | Missense_Mutation | rs377090568 | c.1280N>T | p.Pro427Leu | p.P427L | P23526 | protein_coding | tolerated_low_confidence(0.06) | benign(0.118) | TCGA-AR-A24L-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | PD |
AHCY | SNV | Missense_Mutation | novel | c.243C>G | p.Ile81Met | p.I81M | P23526 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
AHCY | SNV | Missense_Mutation | novel | c.635N>A | p.Ala212Asp | p.A212D | P23526 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.973) | TCGA-BH-A18Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AHCY | SNV | Missense_Mutation | c.322N>C | p.Glu108Gln | p.E108Q | P23526 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.876) | TCGA-C8-A134-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
AHCY | insertion | Frame_Shift_Ins | novel | c.220-1_220insCCCAGCGACCCCACAGGAAAGAGCTGCTTTGTCCCAT | p.Val74ProfsTer54 | p.V74Pfs*54 | P23526 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AHCY | SNV | Missense_Mutation | rs767274069 | c.1027N>T | p.Arg343Trp | p.R343W | P23526 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.966) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AHCY | SNV | Missense_Mutation | novel | c.501G>A | p.Met167Ile | p.M167I | P23526 | protein_coding | deleterious_low_confidence(0) | benign(0.115) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
AHCY | SNV | Missense_Mutation | novel | c.802G>C | p.Glu268Gln | p.E268Q | P23526 | protein_coding | tolerated_low_confidence(0.24) | benign(0.056) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AHCY | SNV | Missense_Mutation | c.722N>C | p.Ile241Thr | p.I241T | P23526 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.871) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
AHCY | SNV | Missense_Mutation | c.1094A>G | p.Gln365Arg | p.Q365R | P23526 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.829) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
191 | AHCY | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR, ENZYME | inhibitor | 178101808 | CHEMBL202701 |
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