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Gene: YTHDC1 |
Gene summary for YTHDC1 |
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Gene information | Species | Human | Gene symbol | YTHDC1 | Gene ID | 91746 |
Gene name | YTH domain containing 1 | |
Gene Alias | YT521 | |
Cytomap | 4q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96MU7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91746 | YTHDC1 | LZE4T | Human | Esophagus | ESCC | 1.17e-23 | 6.48e-01 | 0.0811 |
91746 | YTHDC1 | LZE7T | Human | Esophagus | ESCC | 9.51e-07 | 7.92e-01 | 0.0667 |
91746 | YTHDC1 | LZE8T | Human | Esophagus | ESCC | 1.52e-12 | 3.57e-01 | 0.067 |
91746 | YTHDC1 | LZE20T | Human | Esophagus | ESCC | 5.53e-06 | 5.02e-01 | 0.0662 |
91746 | YTHDC1 | LZE24T | Human | Esophagus | ESCC | 1.74e-14 | 5.77e-01 | 0.0596 |
91746 | YTHDC1 | LZE21T | Human | Esophagus | ESCC | 1.38e-05 | 7.44e-01 | 0.0655 |
91746 | YTHDC1 | LZE6T | Human | Esophagus | ESCC | 5.29e-10 | 1.41e-01 | 0.0845 |
91746 | YTHDC1 | P1T-E | Human | Esophagus | ESCC | 1.68e-17 | 9.90e-01 | 0.0875 |
91746 | YTHDC1 | P2T-E | Human | Esophagus | ESCC | 1.05e-51 | 9.08e-01 | 0.1177 |
91746 | YTHDC1 | P4T-E | Human | Esophagus | ESCC | 1.20e-28 | 8.49e-01 | 0.1323 |
91746 | YTHDC1 | P5T-E | Human | Esophagus | ESCC | 1.18e-21 | 4.85e-01 | 0.1327 |
91746 | YTHDC1 | P8T-E | Human | Esophagus | ESCC | 3.82e-44 | 7.93e-01 | 0.0889 |
91746 | YTHDC1 | P9T-E | Human | Esophagus | ESCC | 4.11e-14 | 5.30e-01 | 0.1131 |
91746 | YTHDC1 | P10T-E | Human | Esophagus | ESCC | 2.53e-39 | 8.01e-01 | 0.116 |
91746 | YTHDC1 | P11T-E | Human | Esophagus | ESCC | 2.08e-12 | 8.46e-01 | 0.1426 |
91746 | YTHDC1 | P12T-E | Human | Esophagus | ESCC | 5.35e-40 | 7.66e-01 | 0.1122 |
91746 | YTHDC1 | P15T-E | Human | Esophagus | ESCC | 2.21e-31 | 8.24e-01 | 0.1149 |
91746 | YTHDC1 | P16T-E | Human | Esophagus | ESCC | 1.66e-40 | 7.08e-01 | 0.1153 |
91746 | YTHDC1 | P17T-E | Human | Esophagus | ESCC | 3.48e-09 | 6.15e-01 | 0.1278 |
91746 | YTHDC1 | P19T-E | Human | Esophagus | ESCC | 4.16e-07 | 6.50e-01 | 0.1662 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000038126 | Thyroid | ATC | regulation of alternative mRNA splicing, via spliceosome | 36/6293 | 60/18723 | 2.48e-05 | 2.16e-04 | 36 |
GO:000637812 | Thyroid | ATC | mRNA polyadenylation | 28/6293 | 44/18723 | 4.39e-05 | 3.54e-04 | 28 |
GO:000640613 | Thyroid | ATC | mRNA export from nucleus | 34/6293 | 59/18723 | 1.29e-04 | 9.10e-04 | 34 |
GO:007142713 | Thyroid | ATC | mRNA-containing ribonucleoprotein complex export from nucleus | 34/6293 | 59/18723 | 1.29e-04 | 9.10e-04 | 34 |
GO:000024515 | Thyroid | ATC | spliceosomal complex assembly | 38/6293 | 79/18723 | 5.28e-03 | 2.15e-02 | 38 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YTHDC1 | SNV | Missense_Mutation | novel | c.1038N>A | p.Ser346Arg | p.S346R | protein_coding | tolerated(0.3) | benign(0.157) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
YTHDC1 | SNV | Missense_Mutation | c.485N>A | p.Arg162His | p.R162H | protein_coding | tolerated_low_confidence(0.08) | benign(0.361) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
YTHDC1 | SNV | Missense_Mutation | c.937N>T | p.Asp313Tyr | p.D313Y | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-AQ-A1H2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | herceptin | SD | ||
YTHDC1 | SNV | Missense_Mutation | rs766073192 | c.561N>G | p.Ser187Arg | p.S187R | protein_coding | deleterious_low_confidence(0) | benign(0.191) | TCGA-AQ-A1H3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
YTHDC1 | SNV | Missense_Mutation | c.92A>G | p.Tyr31Cys | p.Y31C | protein_coding | tolerated_low_confidence(0.26) | probably_damaging(0.996) | TCGA-AR-A2LQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | ||
YTHDC1 | SNV | Missense_Mutation | c.1165N>A | p.Leu389Ile | p.L389I | protein_coding | deleterious(0.05) | benign(0.174) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
YTHDC1 | SNV | Missense_Mutation | rs756562328 | c.2044N>T | p.Arg682Trp | p.R682W | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.649) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
YTHDC1 | SNV | Missense_Mutation | novel | c.713A>T | p.Glu238Val | p.E238V | protein_coding | tolerated_low_confidence(0.08) | benign(0.006) | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
YTHDC1 | insertion | Nonsense_Mutation | novel | c.260_261insCCAATTCTCTGATGTTTAAAGA | p.Lys88GlnfsTer6 | p.K88Qfs*6 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
YTHDC1 | SNV | Missense_Mutation | novel | c.280G>A | p.Glu94Lys | p.E94K | protein_coding | deleterious_low_confidence(0.01) | benign(0.051) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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