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Gene: SNX1 |
Gene summary for SNX1 |
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Gene information | Species | Human | Gene symbol | SNX1 | Gene ID | 6642 |
Gene name | sorting nexin 1 | |
Gene Alias | HsT17379 | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q13596 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6642 | SNX1 | LZE2T | Human | Esophagus | ESCC | 4.47e-02 | 4.23e-01 | 0.082 |
6642 | SNX1 | LZE4T | Human | Esophagus | ESCC | 8.41e-14 | 4.15e-01 | 0.0811 |
6642 | SNX1 | LZE7T | Human | Esophagus | ESCC | 3.76e-09 | 6.14e-01 | 0.0667 |
6642 | SNX1 | LZE8T | Human | Esophagus | ESCC | 5.92e-09 | 2.21e-01 | 0.067 |
6642 | SNX1 | LZE20T | Human | Esophagus | ESCC | 3.91e-05 | 1.67e-01 | 0.0662 |
6642 | SNX1 | LZE24T | Human | Esophagus | ESCC | 4.38e-22 | 3.92e-01 | 0.0596 |
6642 | SNX1 | LZE21T | Human | Esophagus | ESCC | 1.90e-05 | 2.02e-01 | 0.0655 |
6642 | SNX1 | LZE6T | Human | Esophagus | ESCC | 9.07e-05 | 2.80e-01 | 0.0845 |
6642 | SNX1 | P1T-E | Human | Esophagus | ESCC | 1.25e-08 | 6.16e-01 | 0.0875 |
6642 | SNX1 | P2T-E | Human | Esophagus | ESCC | 5.33e-31 | 7.67e-01 | 0.1177 |
6642 | SNX1 | P4T-E | Human | Esophagus | ESCC | 2.54e-29 | 8.41e-01 | 0.1323 |
6642 | SNX1 | P5T-E | Human | Esophagus | ESCC | 5.68e-20 | 3.36e-01 | 0.1327 |
6642 | SNX1 | P8T-E | Human | Esophagus | ESCC | 3.60e-40 | 8.54e-01 | 0.0889 |
6642 | SNX1 | P9T-E | Human | Esophagus | ESCC | 7.52e-12 | 3.67e-01 | 0.1131 |
6642 | SNX1 | P10T-E | Human | Esophagus | ESCC | 6.44e-35 | 6.55e-01 | 0.116 |
6642 | SNX1 | P11T-E | Human | Esophagus | ESCC | 6.28e-10 | 6.03e-01 | 0.1426 |
6642 | SNX1 | P12T-E | Human | Esophagus | ESCC | 9.19e-40 | 8.10e-01 | 0.1122 |
6642 | SNX1 | P15T-E | Human | Esophagus | ESCC | 5.68e-52 | 1.11e+00 | 0.1149 |
6642 | SNX1 | P16T-E | Human | Esophagus | ESCC | 1.09e-74 | 2.24e+00 | 0.1153 |
6642 | SNX1 | P17T-E | Human | Esophagus | ESCC | 9.76e-07 | 4.25e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00608401 | Thyroid | ATC | artery development | 48/6293 | 100/18723 | 1.97e-03 | 9.52e-03 | 48 |
GO:0035904 | Thyroid | ATC | aorta development | 30/6293 | 58/18723 | 3.31e-03 | 1.48e-02 | 30 |
GO:003162310 | Thyroid | ATC | receptor internalization | 52/6293 | 113/18723 | 4.05e-03 | 1.74e-02 | 52 |
GO:004354715 | Thyroid | ATC | positive regulation of GTPase activity | 106/6293 | 255/18723 | 4.58e-03 | 1.89e-02 | 106 |
GO:0060976 | Thyroid | ATC | coronary vasculature development | 24/6293 | 46/18723 | 7.13e-03 | 2.82e-02 | 24 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414425 | Prostate | BPH | Endocytosis | 89/1718 | 251/8465 | 1.06e-08 | 1.29e-07 | 7.99e-08 | 89 |
hsa04144111 | Prostate | BPH | Endocytosis | 89/1718 | 251/8465 | 1.06e-08 | 1.29e-07 | 7.99e-08 | 89 |
hsa0414426 | Prostate | Tumor | Endocytosis | 92/1791 | 251/8465 | 7.83e-09 | 1.04e-07 | 6.43e-08 | 92 |
hsa0414435 | Prostate | Tumor | Endocytosis | 92/1791 | 251/8465 | 7.83e-09 | 1.04e-07 | 6.43e-08 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX1 | SNV | Missense_Mutation | novel | c.38N>C | p.Arg13Thr | p.R13T | Q13596 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.886) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
SNX1 | SNV | Missense_Mutation | c.76G>A | p.Glu26Lys | p.E26K | Q13596 | protein_coding | tolerated_low_confidence(0.25) | benign(0.221) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SNX1 | SNV | Missense_Mutation | rs780100137 | c.1424N>A | p.Arg475Gln | p.R475Q | Q13596 | protein_coding | deleterious(0.04) | probably_damaging(0.939) | TCGA-BH-A0BT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SNX1 | insertion | Nonsense_Mutation | novel | c.1435_1436insGGCCTTCCTGAGGCCTAGTCCCCCTGTTCTTTTTC | p.Ile479ArgfsTer4 | p.I479Rfs*4 | Q13596 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
SNX1 | insertion | In_Frame_Ins | novel | c.478_479insGTAAAC | p.Asn160delinsSerLysHis | p.N160delinsSKH | Q13596 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SNX1 | SNV | Missense_Mutation | rs754631936 | c.1300N>A | p.Glu434Lys | p.E434K | Q13596 | protein_coding | tolerated(0.6) | probably_damaging(0.973) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNX1 | SNV | Missense_Mutation | c.1306C>T | p.Arg436Trp | p.R436W | Q13596 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-C5-A2M2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SNX1 | SNV | Missense_Mutation | c.262C>G | p.Leu88Val | p.L88V | Q13596 | protein_coding | deleterious(0.01) | possibly_damaging(0.668) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SNX1 | SNV | Missense_Mutation | c.76N>C | p.Glu26Gln | p.E26Q | Q13596 | protein_coding | tolerated_low_confidence(0.19) | possibly_damaging(0.51) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SNX1 | SNV | Missense_Mutation | novel | c.1291C>T | p.Arg431Trp | p.R431W | Q13596 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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