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Gene: S100A10 |
Gene summary for S100A10 |
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Gene information | Species | Human | Gene symbol | S100A10 | Gene ID | 6281 |
Gene name | S100 calcium binding protein A10 | |
Gene Alias | 42C | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P60903 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6281 | S100A10 | GSM4909281 | Human | Breast | IDC | 5.97e-08 | 3.56e-01 | 0.21 |
6281 | S100A10 | GSM4909282 | Human | Breast | IDC | 1.01e-47 | 7.31e-01 | -0.0288 |
6281 | S100A10 | GSM4909285 | Human | Breast | IDC | 9.62e-15 | 4.98e-01 | 0.21 |
6281 | S100A10 | GSM4909286 | Human | Breast | IDC | 4.08e-25 | -8.65e-01 | 0.1081 |
6281 | S100A10 | GSM4909290 | Human | Breast | IDC | 7.88e-03 | 2.24e-01 | 0.2096 |
6281 | S100A10 | GSM4909293 | Human | Breast | IDC | 5.88e-15 | -5.17e-01 | 0.1581 |
6281 | S100A10 | GSM4909297 | Human | Breast | IDC | 1.54e-09 | 2.18e-01 | 0.1517 |
6281 | S100A10 | GSM4909298 | Human | Breast | IDC | 1.68e-25 | -7.93e-01 | 0.1551 |
6281 | S100A10 | GSM4909299 | Human | Breast | IDC | 1.11e-02 | 6.45e-03 | 0.035 |
6281 | S100A10 | GSM4909301 | Human | Breast | IDC | 8.34e-47 | -1.05e+00 | 0.1577 |
6281 | S100A10 | GSM4909303 | Human | Breast | IDC | 4.94e-04 | -7.06e-01 | 0.0438 |
6281 | S100A10 | GSM4909304 | Human | Breast | IDC | 1.95e-05 | -1.45e-01 | 0.1636 |
6281 | S100A10 | GSM4909305 | Human | Breast | IDC | 1.13e-02 | -4.62e-02 | 0.0436 |
6281 | S100A10 | GSM4909308 | Human | Breast | IDC | 5.27e-22 | -8.39e-01 | 0.158 |
6281 | S100A10 | GSM4909311 | Human | Breast | IDC | 2.57e-21 | -5.51e-01 | 0.1534 |
6281 | S100A10 | GSM4909312 | Human | Breast | IDC | 3.91e-16 | -5.88e-01 | 0.1552 |
6281 | S100A10 | GSM4909315 | Human | Breast | IDC | 1.02e-139 | 1.13e+00 | 0.21 |
6281 | S100A10 | GSM4909316 | Human | Breast | IDC | 2.73e-33 | 9.30e-01 | 0.21 |
6281 | S100A10 | GSM4909319 | Human | Breast | IDC | 2.14e-34 | -7.44e-01 | 0.1563 |
6281 | S100A10 | GSM4909321 | Human | Breast | IDC | 2.80e-02 | -2.89e-01 | 0.1559 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005149520 | Esophagus | ESCC | positive regulation of cytoskeleton organization | 147/8552 | 226/18723 | 2.93e-09 | 6.38e-08 | 147 |
GO:003158919 | Esophagus | ESCC | cell-substrate adhesion | 221/8552 | 363/18723 | 3.06e-09 | 6.62e-08 | 221 |
GO:001081020 | Esophagus | ESCC | regulation of cell-substrate adhesion | 144/8552 | 221/18723 | 3.55e-09 | 7.45e-08 | 144 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:004804116 | Esophagus | ESCC | focal adhesion assembly | 65/8552 | 87/18723 | 3.28e-08 | 6.08e-07 | 65 |
GO:004578527 | Esophagus | ESCC | positive regulation of cell adhesion | 255/8552 | 437/18723 | 5.07e-08 | 9.11e-07 | 255 |
GO:0032970111 | Esophagus | ESCC | regulation of actin filament-based process | 231/8552 | 397/18723 | 2.91e-07 | 4.20e-06 | 231 |
GO:001081126 | Esophagus | ESCC | positive regulation of cell-substrate adhesion | 84/8552 | 123/18723 | 3.18e-07 | 4.50e-06 | 84 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
GO:011005327 | Esophagus | ESCC | regulation of actin filament organization | 166/8552 | 278/18723 | 1.54e-06 | 1.85e-05 | 166 |
GO:000195217 | Esophagus | ESCC | regulation of cell-matrix adhesion | 85/8552 | 128/18723 | 1.70e-06 | 2.02e-05 | 85 |
GO:000716018 | Esophagus | ESCC | cell-matrix adhesion | 141/8552 | 233/18723 | 3.33e-06 | 3.71e-05 | 141 |
GO:005101727 | Esophagus | ESCC | actin filament bundle assembly | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:015011619 | Esophagus | ESCC | regulation of cell-substrate junction organization | 51/8552 | 71/18723 | 6.99e-06 | 7.04e-05 | 51 |
GO:006157227 | Esophagus | ESCC | actin filament bundle organization | 101/8552 | 161/18723 | 9.22e-06 | 8.82e-05 | 101 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:005189318 | Esophagus | ESCC | regulation of focal adhesion assembly | 47/8552 | 66/18723 | 2.31e-05 | 1.98e-04 | 47 |
GO:009010918 | Esophagus | ESCC | regulation of cell-substrate junction assembly | 47/8552 | 66/18723 | 2.31e-05 | 1.98e-04 | 47 |
GO:000941020 | Esophagus | ESCC | response to xenobiotic stimulus | 253/8552 | 462/18723 | 4.55e-05 | 3.58e-04 | 253 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0513243 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0513253 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0513244 | Cervix | N_HPV | Salmonella infection | 28/349 | 249/8465 | 1.18e-06 | 1.64e-05 | 1.28e-05 | 28 |
hsa0513254 | Cervix | N_HPV | Salmonella infection | 28/349 | 249/8465 | 1.18e-06 | 1.64e-05 | 1.28e-05 | 28 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa051322 | Colorectum | SER | Salmonella infection | 77/1580 | 249/8465 | 1.56e-06 | 2.35e-05 | 1.71e-05 | 77 |
hsa051323 | Colorectum | SER | Salmonella infection | 77/1580 | 249/8465 | 1.56e-06 | 2.35e-05 | 1.71e-05 | 77 |
hsa051324 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa051325 | Colorectum | MSS | Salmonella infection | 92/1875 | 249/8465 | 5.23e-08 | 9.74e-07 | 5.97e-07 | 92 |
hsa051326 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa051327 | Colorectum | MSI-H | Salmonella infection | 43/797 | 249/8465 | 5.91e-05 | 8.33e-04 | 6.98e-04 | 43 |
hsa051328 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
hsa051329 | Colorectum | FAP | Salmonella infection | 67/1404 | 249/8465 | 2.04e-05 | 2.52e-04 | 1.53e-04 | 67 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A10 | SNV | Missense_Mutation | c.104N>G | p.Met35Arg | p.M35R | P60903 | protein_coding | deleterious(0.01) | benign(0.424) | TCGA-AR-A0TP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
S100A10 | SNV | Missense_Mutation | novel | c.224N>G | p.Leu75Arg | p.L75R | P60903 | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | rs11542012 | c.230N>T | p.Ala77Val | p.A77V | P60903 | protein_coding | tolerated(0.3) | benign(0.104) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | rs374528021 | c.211N>G | p.Ser71Gly | p.S71G | P60903 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | novel | c.216C>A | p.Phe72Leu | p.F72L | P60903 | protein_coding | tolerated(0.1) | benign(0.132) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | novel | c.183N>T | p.Gln61His | p.Q61H | P60903 | protein_coding | deleterious(0.03) | benign(0.013) | TCGA-CV-6937-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
S100A10 | SNV | Missense_Mutation | novel | c.250A>T | p.Asn84Tyr | p.N84Y | P60903 | protein_coding | deleterious(0.02) | possibly_damaging(0.703) | TCGA-UF-A7JV-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
S100A10 | insertion | Frame_Shift_Ins | novel | c.265_266insGGTACATGTGTATAACGCGCAGGTTTGT | p.Val89GlyfsTer29 | p.V89Gfs*29 | P60903 | protein_coding | TCGA-CG-4440-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6281 | S100A10 | KINASE | GONADOTROPINS | 11356677 | ||
6281 | S100A10 | KINASE | DEXAMETHASONE | DEXAMETHASONE | 10358078 |
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