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Gene: RNF2 |
Gene summary for RNF2 |
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Gene information | Species | Human | Gene symbol | RNF2 | Gene ID | 6045 |
Gene name | ring finger protein 2 | |
Gene Alias | BAP-1 | |
Cytomap | 1q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q99496 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6045 | RNF2 | LZE4T | Human | Esophagus | ESCC | 7.12e-03 | 1.03e-01 | 0.0811 |
6045 | RNF2 | LZE8T | Human | Esophagus | ESCC | 2.48e-08 | 1.41e-01 | 0.067 |
6045 | RNF2 | LZE24T | Human | Esophagus | ESCC | 2.31e-19 | 3.44e-01 | 0.0596 |
6045 | RNF2 | LZE6T | Human | Esophagus | ESCC | 1.67e-02 | 1.92e-01 | 0.0845 |
6045 | RNF2 | P1T-E | Human | Esophagus | ESCC | 6.43e-03 | 2.00e-01 | 0.0875 |
6045 | RNF2 | P2T-E | Human | Esophagus | ESCC | 9.00e-29 | 4.63e-01 | 0.1177 |
6045 | RNF2 | P4T-E | Human | Esophagus | ESCC | 4.16e-15 | 3.56e-01 | 0.1323 |
6045 | RNF2 | P5T-E | Human | Esophagus | ESCC | 1.20e-23 | 5.29e-01 | 0.1327 |
6045 | RNF2 | P8T-E | Human | Esophagus | ESCC | 1.32e-14 | 1.75e-01 | 0.0889 |
6045 | RNF2 | P9T-E | Human | Esophagus | ESCC | 3.02e-16 | 2.91e-01 | 0.1131 |
6045 | RNF2 | P10T-E | Human | Esophagus | ESCC | 1.95e-21 | 4.38e-01 | 0.116 |
6045 | RNF2 | P11T-E | Human | Esophagus | ESCC | 3.36e-09 | 4.31e-01 | 0.1426 |
6045 | RNF2 | P12T-E | Human | Esophagus | ESCC | 1.45e-06 | 2.82e-01 | 0.1122 |
6045 | RNF2 | P15T-E | Human | Esophagus | ESCC | 9.35e-24 | 5.15e-01 | 0.1149 |
6045 | RNF2 | P16T-E | Human | Esophagus | ESCC | 7.63e-31 | 5.73e-01 | 0.1153 |
6045 | RNF2 | P17T-E | Human | Esophagus | ESCC | 7.75e-05 | 3.14e-01 | 0.1278 |
6045 | RNF2 | P19T-E | Human | Esophagus | ESCC | 1.31e-02 | 4.86e-01 | 0.1662 |
6045 | RNF2 | P20T-E | Human | Esophagus | ESCC | 9.47e-22 | 4.39e-01 | 0.1124 |
6045 | RNF2 | P21T-E | Human | Esophagus | ESCC | 2.43e-19 | 2.73e-01 | 0.1617 |
6045 | RNF2 | P22T-E | Human | Esophagus | ESCC | 3.54e-13 | 2.73e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190305019 | Prostate | Tumor | regulation of proteolysis involved in cellular protein catabolic process | 83/3246 | 221/18723 | 5.12e-13 | 5.49e-11 | 83 |
GO:003133119 | Prostate | Tumor | positive regulation of cellular catabolic process | 134/3246 | 427/18723 | 5.54e-13 | 5.84e-11 | 134 |
GO:004316119 | Prostate | Tumor | proteasome-mediated ubiquitin-dependent protein catabolic process | 130/3246 | 412/18723 | 7.97e-13 | 8.00e-11 | 130 |
GO:200005819 | Prostate | Tumor | regulation of ubiquitin-dependent protein catabolic process | 66/3246 | 164/18723 | 3.30e-12 | 2.78e-10 | 66 |
GO:006113619 | Prostate | Tumor | regulation of proteasomal protein catabolic process | 71/3246 | 187/18723 | 1.34e-11 | 1.00e-09 | 71 |
GO:004573219 | Prostate | Tumor | positive regulation of protein catabolic process | 82/3246 | 231/18723 | 2.13e-11 | 1.49e-09 | 82 |
GO:003243419 | Prostate | Tumor | regulation of proteasomal ubiquitin-dependent protein catabolic process | 55/3246 | 134/18723 | 8.40e-11 | 5.27e-09 | 55 |
GO:001605514 | Prostate | Tumor | Wnt signaling pathway | 131/3246 | 444/18723 | 1.16e-10 | 7.11e-09 | 131 |
GO:019873814 | Prostate | Tumor | cell-cell signaling by wnt | 131/3246 | 446/18723 | 1.61e-10 | 9.69e-09 | 131 |
GO:003011114 | Prostate | Tumor | regulation of Wnt signaling pathway | 99/3246 | 328/18723 | 5.92e-09 | 2.34e-07 | 99 |
GO:190336419 | Prostate | Tumor | positive regulation of cellular protein catabolic process | 56/3246 | 155/18723 | 1.51e-08 | 5.43e-07 | 56 |
GO:200006019 | Prostate | Tumor | positive regulation of ubiquitin-dependent protein catabolic process | 41/3246 | 107/18723 | 1.99e-07 | 4.86e-06 | 41 |
GO:003243618 | Prostate | Tumor | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 36/3246 | 90/18723 | 3.15e-07 | 7.14e-06 | 36 |
GO:190305216 | Prostate | Tumor | positive regulation of proteolysis involved in cellular protein catabolic process | 47/3246 | 133/18723 | 4.46e-07 | 9.77e-06 | 47 |
GO:190180017 | Prostate | Tumor | positive regulation of proteasomal protein catabolic process | 42/3246 | 114/18723 | 4.99e-07 | 1.08e-05 | 42 |
GO:000020914 | Prostate | Tumor | protein polyubiquitination | 64/3246 | 236/18723 | 1.08e-04 | 1.03e-03 | 64 |
GO:003017813 | Prostate | Tumor | negative regulation of Wnt signaling pathway | 46/3246 | 170/18723 | 9.84e-04 | 6.37e-03 | 46 |
GO:190331126 | Skin | cSCC | regulation of mRNA metabolic process | 162/4864 | 288/18723 | 5.90e-28 | 2.46e-25 | 162 |
GO:005068425 | Skin | cSCC | regulation of mRNA processing | 92/4864 | 137/18723 | 4.81e-24 | 1.08e-21 | 92 |
GO:190332029 | Skin | cSCC | regulation of protein modification by small protein conjugation or removal | 125/4864 | 242/18723 | 9.50e-18 | 1.05e-15 | 125 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF2 | SNV | Missense_Mutation | novel | c.848N>C | p.Leu283Pro | p.L283P | Q99496 | protein_coding | deleterious(0.02) | possibly_damaging(0.799) | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RNF2 | SNV | Missense_Mutation | c.473G>A | p.Arg158Gln | p.R158Q | Q99496 | protein_coding | deleterious(0.01) | possibly_damaging(0.726) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RNF2 | SNV | Missense_Mutation | c.128G>A | p.Arg43Gln | p.R43Q | Q99496 | protein_coding | deleterious(0) | possibly_damaging(0.759) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNF2 | SNV | Missense_Mutation | novel | c.293G>T | p.Arg98Ile | p.R98I | Q99496 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF2 | SNV | Missense_Mutation | c.577A>T | p.Ser193Cys | p.S193C | Q99496 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNF2 | SNV | Missense_Mutation | novel | c.339N>G | p.Ile113Met | p.I113M | Q99496 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RNF2 | SNV | Missense_Mutation | c.587G>A | p.Arg196Gln | p.R196Q | Q99496 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RNF2 | SNV | Missense_Mutation | c.77G>A | p.Arg26Gln | p.R26Q | Q99496 | protein_coding | deleterious(0.04) | possibly_damaging(0.688) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RNF2 | SNV | Missense_Mutation | c.77N>A | p.Arg26Gln | p.R26Q | Q99496 | protein_coding | deleterious(0.04) | possibly_damaging(0.688) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
RNF2 | insertion | Frame_Shift_Ins | novel | c.971_972insA | p.Met325HisfsTer16 | p.M325Hfs*16 | Q99496 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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