Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/MAP1B_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MAP1B_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/MAP1B_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/MAP1B_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/MAP1B_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MAP1B_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083617 | Prostate | BPH | regulation of cell size | 45/3107 | 181/18723 | 2.79e-03 | 1.47e-02 | 45 |
GO:19901387 | Prostate | BPH | neuron projection extension | 43/3107 | 172/18723 | 3.06e-03 | 1.60e-02 | 43 |
GO:00611624 | Prostate | BPH | establishment of monopolar cell polarity | 10/3107 | 24/18723 | 3.21e-03 | 1.67e-02 | 10 |
GO:00486388 | Prostate | BPH | regulation of developmental growth | 74/3107 | 330/18723 | 3.43e-03 | 1.76e-02 | 74 |
GO:00507706 | Prostate | BPH | regulation of axonogenesis | 39/3107 | 154/18723 | 3.65e-03 | 1.85e-02 | 39 |
GO:00311102 | Prostate | BPH | regulation of microtubule polymerization or depolymerization | 25/3107 | 88/18723 | 3.76e-03 | 1.89e-02 | 25 |
GO:00507726 | Prostate | BPH | positive regulation of axonogenesis | 23/3107 | 79/18723 | 3.81e-03 | 1.91e-02 | 23 |
GO:00613393 | Prostate | BPH | establishment or maintenance of monopolar cell polarity | 10/3107 | 25/18723 | 4.57e-03 | 2.19e-02 | 10 |
GO:00323872 | Prostate | BPH | negative regulation of intracellular transport | 18/3107 | 58/18723 | 4.75e-03 | 2.27e-02 | 18 |
GO:00457736 | Prostate | BPH | positive regulation of axon extension | 14/3107 | 42/18723 | 6.05e-03 | 2.78e-02 | 14 |
GO:00436243 | Prostate | BPH | cellular protein complex disassembly | 34/3107 | 136/18723 | 7.81e-03 | 3.42e-02 | 34 |
GO:0045664 | Prostate | BPH | regulation of neuron differentiation | 46/3107 | 196/18723 | 7.95e-03 | 3.47e-02 | 46 |
GO:00512614 | Prostate | BPH | protein depolymerization | 29/3107 | 114/18723 | 1.04e-02 | 4.35e-02 | 29 |
GO:00075848 | Prostate | BPH | response to nutrient | 41/3107 | 174/18723 | 1.09e-02 | 4.50e-02 | 41 |
GO:19018802 | Prostate | BPH | negative regulation of protein depolymerization | 20/3107 | 72/18723 | 1.16e-02 | 4.70e-02 | 20 |
GO:190290319 | Prostate | Tumor | regulation of supramolecular fiber organization | 131/3246 | 383/18723 | 6.68e-16 | 1.26e-13 | 131 |
GO:190290519 | Prostate | Tumor | positive regulation of supramolecular fiber organization | 79/3246 | 209/18723 | 1.26e-12 | 1.15e-10 | 79 |
GO:003238614 | Prostate | Tumor | regulation of intracellular transport | 111/3246 | 337/18723 | 1.83e-12 | 1.65e-10 | 111 |
GO:004325419 | Prostate | Tumor | regulation of protein-containing complex assembly | 132/3246 | 428/18723 | 3.32e-12 | 2.78e-10 | 132 |
GO:005149517 | Prostate | Tumor | positive regulation of cytoskeleton organization | 78/3246 | 226/18723 | 3.05e-10 | 1.65e-08 | 78 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP1B | SNV | Missense_Mutation | | c.254N>A | p.Arg85Gln | p.R85Q | P46821 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAP1B | SNV | Missense_Mutation | | c.2220N>T | p.Lys740Asn | p.K740N | P46821 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAP1B | SNV | Missense_Mutation | novel | c.6534N>G | p.Ile2178Met | p.I2178M | P46821 | protein_coding | tolerated(0.25) | probably_damaging(0.984) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
MAP1B | SNV | Missense_Mutation | rs6876207 | c.3662N>G | p.Ser1221Cys | p.S1221C | P46821 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MAP1B | insertion | Frame_Shift_Ins | novel | c.6042_6043insGGGCTTC | p.Thr2015GlyfsTer7 | p.T2015Gfs*7 | P46821 | protein_coding | | | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | | SD |
MAP1B | insertion | Frame_Shift_Ins | novel | c.1478_1479insGTATCTGCAGAGAATATGCTGGGTGACCCACTCATGTTTCAAT | p.Ser493ArgfsTer62 | p.S493Rfs*62 | P46821 | protein_coding | | | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
MAP1B | insertion | Frame_Shift_Ins | novel | c.2748_2749insTGCATGATCCAAAATACTTTATTTCTATGGCTCATTGCCAA | p.Lys917CysfsTer18 | p.K917Cfs*18 | P46821 | protein_coding | | | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
MAP1B | insertion | Frame_Shift_Ins | novel | c.4966_4967insGCAGAGGCAG | p.Gln1656ArgfsTer29 | p.Q1656Rfs*29 | P46821 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
MAP1B | insertion | Frame_Shift_Ins | novel | c.4968_4969insGTAGCCCCGGTGTCTCCTGAGGTGACCCAAGAAG | p.Ser1657ValfsTer36 | p.S1657Vfs*36 | P46821 | protein_coding | | | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
MAP1B | insertion | Frame_Shift_Ins | novel | c.1503_1504insGAGATGAGGT | p.Leu502GlufsTer42 | p.L502Efs*42 | P46821 | protein_coding | | | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |