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Gene: IL1B |
Gene summary for IL1B |
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Gene information | Species | Human | Gene symbol | IL1B | Gene ID | 3553 |
Gene name | interleukin 1 beta | |
Gene Alias | IL-1 | |
Cytomap | 2q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P01584 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3553 | IL1B | LZE24T | Human | Esophagus | ESCC | 2.37e-02 | -8.50e-02 | 0.0596 |
3553 | IL1B | P5T-E | Human | Esophagus | ESCC | 2.88e-17 | 9.39e-01 | 0.1327 |
3553 | IL1B | P11T-E | Human | Esophagus | ESCC | 1.15e-05 | 1.15e+00 | 0.1426 |
3553 | IL1B | P21T-E | Human | Esophagus | ESCC | 2.10e-13 | 1.12e+00 | 0.1617 |
3553 | IL1B | P38T-E | Human | Esophagus | ESCC | 4.43e-06 | 1.46e+00 | 0.127 |
3553 | IL1B | P47T-E | Human | Esophagus | ESCC | 1.83e-07 | 4.18e-01 | 0.1067 |
3553 | IL1B | P89T-E | Human | Esophagus | ESCC | 4.52e-19 | 3.63e+00 | 0.1752 |
3553 | IL1B | P130T-E | Human | Esophagus | ESCC | 1.01e-36 | 2.56e+00 | 0.1676 |
3553 | IL1B | C04 | Human | Oral cavity | OSCC | 4.22e-10 | 2.13e+00 | 0.2633 |
3553 | IL1B | C21 | Human | Oral cavity | OSCC | 2.18e-60 | 2.83e+00 | 0.2678 |
3553 | IL1B | C30 | Human | Oral cavity | OSCC | 7.86e-32 | 1.39e+00 | 0.3055 |
3553 | IL1B | C43 | Human | Oral cavity | OSCC | 2.50e-02 | 4.06e-01 | 0.1704 |
3553 | IL1B | C51 | Human | Oral cavity | OSCC | 3.82e-14 | 4.84e-01 | 0.2674 |
3553 | IL1B | C57 | Human | Oral cavity | OSCC | 8.32e-08 | 4.99e-01 | 0.1679 |
3553 | IL1B | C06 | Human | Oral cavity | OSCC | 2.94e-06 | 1.59e+00 | 0.2699 |
3553 | IL1B | C07 | Human | Oral cavity | OSCC | 7.37e-05 | 7.16e-01 | 0.2491 |
3553 | IL1B | C08 | Human | Oral cavity | OSCC | 2.91e-08 | 3.52e-01 | 0.1919 |
3553 | IL1B | C09 | Human | Oral cavity | OSCC | 4.96e-02 | 3.10e-02 | 0.1431 |
3553 | IL1B | PTCwithHT_1 | Human | Thyroid | HT | 5.71e-22 | 1.41e+00 | 0.0238 |
3553 | IL1B | PTCwithHT_8 | Human | Thyroid | HT | 4.31e-16 | 8.93e-01 | 0.0351 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00329465 | Thyroid | HT | positive regulation of mononuclear cell proliferation | 18/1272 | 138/18723 | 5.75e-03 | 3.72e-02 | 18 |
GO:19010993 | Thyroid | HT | negative regulation of signal transduction in absence of ligand | 7/1272 | 33/18723 | 5.88e-03 | 3.74e-02 | 7 |
GO:20012403 | Thyroid | HT | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | 7/1272 | 33/18723 | 5.88e-03 | 3.74e-02 | 7 |
GO:00703047 | Thyroid | HT | positive regulation of stress-activated protein kinase signaling cascade | 17/1272 | 128/18723 | 5.97e-03 | 3.77e-02 | 17 |
GO:00434075 | Thyroid | HT | negative regulation of MAP kinase activity | 10/1272 | 59/18723 | 6.00e-03 | 3.77e-02 | 10 |
GO:00513535 | Thyroid | HT | positive regulation of oxidoreductase activity | 10/1272 | 59/18723 | 6.00e-03 | 3.77e-02 | 10 |
GO:009031620 | Thyroid | HT | positive regulation of intracellular protein transport | 20/1272 | 160/18723 | 6.03e-03 | 3.79e-02 | 20 |
GO:00706658 | Thyroid | HT | positive regulation of leukocyte proliferation | 19/1272 | 150/18723 | 6.36e-03 | 3.97e-02 | 19 |
GO:00024567 | Thyroid | HT | T cell mediated immunity | 15/1272 | 109/18723 | 6.84e-03 | 4.19e-02 | 15 |
GO:00327701 | Thyroid | HT | positive regulation of monooxygenase activity | 7/1272 | 34/18723 | 6.98e-03 | 4.22e-02 | 7 |
GO:003286820 | Thyroid | HT | response to insulin | 29/1272 | 264/18723 | 7.25e-03 | 4.35e-02 | 29 |
GO:00065096 | Thyroid | HT | membrane protein ectodomain proteolysis | 8/1272 | 43/18723 | 7.63e-03 | 4.50e-02 | 8 |
GO:00107185 | Thyroid | HT | positive regulation of epithelial to mesenchymal transition | 9/1272 | 52/18723 | 7.78e-03 | 4.57e-02 | 9 |
GO:000734618 | Thyroid | HT | regulation of mitotic cell cycle | 45/1272 | 457/18723 | 7.86e-03 | 4.61e-02 | 45 |
GO:004620918 | Thyroid | HT | nitric oxide metabolic process | 12/1272 | 81/18723 | 8.32e-03 | 4.79e-02 | 12 |
GO:00604858 | Thyroid | HT | mesenchyme development | 31/1272 | 291/18723 | 8.69e-03 | 4.92e-02 | 31 |
GO:0050999 | Thyroid | HT | regulation of nitric-oxide synthase activity | 8/1272 | 44/18723 | 8.78e-03 | 4.95e-02 | 8 |
GO:0009896113 | Thyroid | PTC | positive regulation of catabolic process | 278/5968 | 492/18723 | 3.35e-30 | 2.64e-27 | 278 |
GO:0031331113 | Thyroid | PTC | positive regulation of cellular catabolic process | 249/5968 | 427/18723 | 5.28e-30 | 3.58e-27 | 249 |
GO:0042176113 | Thyroid | PTC | regulation of protein catabolic process | 231/5968 | 391/18723 | 4.76e-29 | 2.14e-26 | 231 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa04932210 | Esophagus | ESCC | Non-alcoholic fatty liver disease | 122/4205 | 155/8465 | 5.69e-14 | 1.59e-12 | 8.14e-13 | 122 |
hsa05020210 | Esophagus | ESCC | Prion disease | 193/4205 | 273/8465 | 6.42e-13 | 1.34e-11 | 6.89e-12 | 193 |
hsa05418211 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0466810 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa0516425 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0513526 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa05171211 | Esophagus | ESCC | Coronavirus disease - COVID-19 | 156/4205 | 232/8465 | 3.18e-08 | 2.68e-07 | 1.37e-07 | 156 |
hsa05417211 | Esophagus | ESCC | Lipid and atherosclerosis | 143/4205 | 215/8465 | 3.30e-07 | 2.45e-06 | 1.26e-06 | 143 |
hsa05163210 | Esophagus | ESCC | Human cytomegalovirus infection | 148/4205 | 225/8465 | 5.73e-07 | 4.00e-06 | 2.05e-06 | 148 |
hsa0493310 | Esophagus | ESCC | AGE-RAGE signaling pathway in diabetic complications | 72/4205 | 100/8465 | 4.15e-06 | 2.28e-05 | 1.17e-05 | 72 |
hsa046259 | Esophagus | ESCC | C-type lectin receptor signaling pathway | 73/4205 | 104/8465 | 1.57e-05 | 7.98e-05 | 4.09e-05 | 73 |
hsa0465727 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0513428 | Esophagus | ESCC | Legionellosis | 42/4205 | 57/8465 | 1.83e-04 | 6.90e-04 | 3.53e-04 | 42 |
hsa051629 | Esophagus | ESCC | Measles | 90/4205 | 139/8465 | 2.16e-04 | 7.87e-04 | 4.03e-04 | 90 |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IL1B | IL1R1_IL1RAP | IL1B_IL1R1_IL1RAP | IL1 | Breast | DCIS |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | Breast | DCIS |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | Cervix | ADJ |
IL1B | IL1R1_IL1RAP | IL1B_IL1R1_IL1RAP | IL1 | Cervix | CC |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | CRC | MSI-H |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | CRC | MSS |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | Endometrium | AEH |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | Endometrium | EEC |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | Esophagus | Healthy |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | GC | ADJ |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | GC | GC |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | HNSCC | ADJ |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | HNSCC | Healthy |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | HNSCC | OSCC |
IL1B | IL1R1_IL1RAP | IL1B_IL1R1_IL1RAP | IL1 | HNSCC | Precancer |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | HNSCC | Precancer |
IL1B | IL1R1_IL1RAP | IL1B_IL1R1_IL1RAP | IL1 | Liver | Healthy |
IL1B | IL1R1_IL1RAP | IL1B_IL1R1_IL1RAP | IL1 | Liver | Precancer |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | Lung | AAH |
IL1B | IL1R2 | IL1B_IL1R2 | IL1 | Lung | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL1B | SNV | Missense_Mutation | c.33N>T | p.Met11Ile | p.M11I | P01584 | protein_coding | tolerated(0.17) | benign(0.026) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
IL1B | SNV | Missense_Mutation | rs766684369 | c.374C>T | p.Thr125Met | p.T125M | P01584 | protein_coding | tolerated(0.06) | probably_damaging(0.984) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
IL1B | SNV | Missense_Mutation | c.738N>A | p.Met246Ile | p.M246I | P01584 | protein_coding | tolerated(0.07) | benign(0.154) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IL1B | SNV | Missense_Mutation | rs762704392 | c.22N>A | p.Ala8Thr | p.A8T | P01584 | protein_coding | tolerated(1) | benign(0.001) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
IL1B | SNV | Missense_Mutation | rs144433180 | c.562N>A | p.Val188Met | p.V188M | P01584 | protein_coding | deleterious(0.02) | possibly_damaging(0.646) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IL1B | SNV | Missense_Mutation | novel | c.261N>T | p.Glu87Asp | p.E87D | P01584 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IL1B | SNV | Missense_Mutation | rs755957216 | c.193N>A | p.Ala65Thr | p.A65T | P01584 | protein_coding | deleterious(0.01) | benign(0.081) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
IL1B | SNV | Missense_Mutation | novel | c.734N>G | p.Asn245Ser | p.N245S | P01584 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IL1B | SNV | Missense_Mutation | rs144640380 | c.423N>C | p.Glu141Asp | p.E141D | P01584 | protein_coding | tolerated(0.05) | possibly_damaging(0.641) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IL1B | SNV | Missense_Mutation | rs775562734 | c.152N>A | p.Arg51Gln | p.R51Q | P01584 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3553 | IL1B | KINASE, DRUGGABLE GENOME | VERAPAMIL | VERAPAMIL | 2686646 | |
3553 | IL1B | KINASE, DRUGGABLE GENOME | ERYTHROMYCIN | ERYTHROMYCIN | 2534682 | |
3553 | IL1B | KINASE, DRUGGABLE GENOME | BECLOMETHASONE DIPROPIONATE | 9176529 | ||
3553 | IL1B | KINASE, DRUGGABLE GENOME | RESVERATROL | RESVERATROL | 16389574 | |
3553 | IL1B | KINASE, DRUGGABLE GENOME | AC-201 | DIACEREIN | ||
3553 | IL1B | KINASE, DRUGGABLE GENOME | XOMA 052 | |||
3553 | IL1B | KINASE, DRUGGABLE GENOME | CHINESE HERBS | 8871284 | ||
3553 | IL1B | KINASE, DRUGGABLE GENOME | aspirin | ASPIRIN | 19448967 | |
3553 | IL1B | KINASE, DRUGGABLE GENOME | ACITRETIN | ACITRETIN | 1431212 | |
3553 | IL1B | KINASE, DRUGGABLE GENOME | risedronate | RISEDRONIC ACID | 16257277 |
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