Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/HSPE1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/HSPE1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/HSPE1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/HSPE1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/HSPE1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HSPE1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/HSPE1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HSPE1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HSPE1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/HSPE1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HSPE1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HSPE1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525475 | Stomach | SIM | regulation of peptidase activity | 54/708 | 461/18723 | 1.46e-13 | 6.25e-11 | 54 |
GO:00525485 | Stomach | SIM | regulation of endopeptidase activity | 51/708 | 432/18723 | 5.26e-13 | 2.07e-10 | 51 |
GO:00610775 | Stomach | SIM | chaperone-mediated protein folding | 18/708 | 67/18723 | 3.33e-11 | 8.72e-09 | 18 |
GO:00359665 | Stomach | SIM | response to topologically incorrect protein | 26/708 | 159/18723 | 2.83e-10 | 6.29e-08 | 26 |
GO:00064585 | Stomach | SIM | 'de novo' protein folding | 14/708 | 43/18723 | 3.05e-10 | 6.29e-08 | 14 |
GO:00069865 | Stomach | SIM | response to unfolded protein | 24/708 | 137/18723 | 3.20e-10 | 6.29e-08 | 24 |
GO:00510855 | Stomach | SIM | chaperone cofactor-dependent protein refolding | 12/708 | 34/18723 | 1.99e-09 | 2.79e-07 | 12 |
GO:00510845 | Stomach | SIM | 'de novo' posttranslational protein folding | 12/708 | 39/18723 | 1.19e-08 | 1.48e-06 | 12 |
GO:200011651 | Stomach | SIM | regulation of cysteine-type endopeptidase activity | 27/708 | 235/18723 | 2.92e-07 | 2.03e-05 | 27 |
GO:00432815 | Stomach | SIM | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 23/708 | 209/18723 | 4.58e-06 | 1.89e-04 | 23 |
GO:004586251 | Stomach | SIM | positive regulation of proteolysis | 32/708 | 372/18723 | 1.41e-05 | 4.83e-04 | 32 |
GO:00109525 | Stomach | SIM | positive regulation of peptidase activity | 21/708 | 197/18723 | 1.92e-05 | 6.11e-04 | 21 |
GO:00109505 | Stomach | SIM | positive regulation of endopeptidase activity | 19/708 | 179/18723 | 5.01e-05 | 1.33e-03 | 19 |
GO:20010564 | Stomach | SIM | positive regulation of cysteine-type endopeptidase activity | 15/708 | 148/18723 | 4.97e-04 | 8.08e-03 | 15 |
GO:00432804 | Stomach | SIM | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 12/708 | 129/18723 | 3.60e-03 | 3.36e-02 | 12 |
GO:000645727 | Thyroid | HT | protein folding | 45/1272 | 212/18723 | 5.29e-12 | 1.01e-09 | 45 |
GO:000698627 | Thyroid | HT | response to unfolded protein | 34/1272 | 137/18723 | 2.36e-11 | 3.75e-09 | 34 |
GO:005254729 | Thyroid | HT | regulation of peptidase activity | 71/1272 | 461/18723 | 6.39e-11 | 9.11e-09 | 71 |
GO:003596627 | Thyroid | HT | response to topologically incorrect protein | 35/1272 | 159/18723 | 4.27e-10 | 4.95e-08 | 35 |
GO:005254829 | Thyroid | HT | regulation of endopeptidase activity | 64/1272 | 432/18723 | 2.80e-09 | 2.68e-07 | 64 |