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Gene: CORO1B |
Gene summary for CORO1B |
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Gene information | Species | Human | Gene symbol | CORO1B | Gene ID | 57175 |
Gene name | coronin 1B | |
Gene Alias | CORONIN-2 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R5K1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57175 | CORO1B | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.20e-04 | 1.56e-01 | 0.0155 |
57175 | CORO1B | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.81e-27 | 7.47e-01 | -0.1808 |
57175 | CORO1B | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.14e-03 | 3.47e-01 | 0.0216 |
57175 | CORO1B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.82e-08 | 3.50e-01 | -0.0811 |
57175 | CORO1B | HTA11_78_2000001011 | Human | Colorectum | AD | 5.30e-17 | 4.25e-01 | -0.1088 |
57175 | CORO1B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-25 | 5.73e-01 | -0.1954 |
57175 | CORO1B | HTA11_411_2000001011 | Human | Colorectum | SER | 9.97e-09 | 9.35e-01 | -0.2602 |
57175 | CORO1B | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.33e-08 | 6.64e-01 | -0.2196 |
57175 | CORO1B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.68e-08 | 3.28e-01 | -0.1207 |
57175 | CORO1B | HTA11_83_2000001011 | Human | Colorectum | SER | 1.29e-04 | 3.17e-01 | -0.1526 |
57175 | CORO1B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.48e-22 | 4.60e-01 | -0.1464 |
57175 | CORO1B | HTA11_866_2000001011 | Human | Colorectum | AD | 3.84e-03 | 1.79e-01 | -0.1001 |
57175 | CORO1B | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.53e-16 | 4.57e-01 | -0.059 |
57175 | CORO1B | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.44e-10 | 5.26e-01 | -0.2061 |
57175 | CORO1B | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.08e-03 | 2.94e-01 | -0.1462 |
57175 | CORO1B | HTA11_546_2000001011 | Human | Colorectum | AD | 3.50e-06 | 3.60e-01 | -0.0842 |
57175 | CORO1B | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-03 | 1.75e-01 | 0.096 |
57175 | CORO1B | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.90e-03 | 4.85e-01 | 0.0451 |
57175 | CORO1B | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.22e-06 | 3.97e-01 | 0.0528 |
57175 | CORO1B | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.27e-08 | 3.95e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003431417 | Thyroid | PTC | Arp2/3 complex-mediated actin nucleation | 24/5968 | 39/18723 | 1.30e-04 | 1.03e-03 | 24 |
GO:190274518 | Thyroid | PTC | positive regulation of lamellipodium organization | 23/5968 | 37/18723 | 1.44e-04 | 1.12e-03 | 23 |
GO:005149419 | Thyroid | PTC | negative regulation of cytoskeleton organization | 73/5968 | 163/18723 | 3.59e-04 | 2.44e-03 | 73 |
GO:009758119 | Thyroid | PTC | lamellipodium organization | 44/5968 | 90/18723 | 5.59e-04 | 3.56e-03 | 44 |
GO:00450109 | Thyroid | PTC | actin nucleation | 28/5968 | 52/18723 | 8.33e-04 | 5.13e-03 | 28 |
GO:190274317 | Thyroid | PTC | regulation of lamellipodium organization | 28/5968 | 54/18723 | 1.79e-03 | 9.68e-03 | 28 |
GO:001481212 | Thyroid | PTC | muscle cell migration | 50/5968 | 110/18723 | 1.93e-03 | 1.04e-02 | 50 |
GO:004354219 | Thyroid | PTC | endothelial cell migration | 112/5968 | 279/18723 | 2.03e-03 | 1.09e-02 | 112 |
GO:00149095 | Thyroid | PTC | smooth muscle cell migration | 44/5968 | 97/18723 | 3.65e-03 | 1.76e-02 | 44 |
GO:1902903210 | Thyroid | ATC | regulation of supramolecular fiber organization | 210/6293 | 383/18723 | 6.20e-18 | 7.54e-16 | 210 |
GO:0043254210 | Thyroid | ATC | regulation of protein-containing complex assembly | 225/6293 | 428/18723 | 2.72e-16 | 2.33e-14 | 225 |
GO:002260429 | Thyroid | ATC | regulation of cell morphogenesis | 171/6293 | 309/18723 | 2.36e-15 | 1.70e-13 | 171 |
GO:0032970210 | Thyroid | ATC | regulation of actin filament-based process | 208/6293 | 397/18723 | 5.82e-15 | 3.80e-13 | 208 |
GO:0007015210 | Thyroid | ATC | actin filament organization | 227/6293 | 442/18723 | 5.96e-15 | 3.85e-13 | 227 |
GO:0032956210 | Thyroid | ATC | regulation of actin cytoskeleton organization | 190/6293 | 358/18723 | 1.73e-14 | 1.01e-12 | 190 |
GO:003134623 | Thyroid | ATC | positive regulation of cell projection organization | 186/6293 | 353/18723 | 7.99e-14 | 4.23e-12 | 186 |
GO:005125829 | Thyroid | ATC | protein polymerization | 159/6293 | 297/18723 | 9.33e-13 | 3.96e-11 | 159 |
GO:0110053210 | Thyroid | ATC | regulation of actin filament organization | 150/6293 | 278/18723 | 1.82e-12 | 7.58e-11 | 150 |
GO:004206034 | Thyroid | ATC | wound healing | 210/6293 | 422/18723 | 3.33e-12 | 1.37e-10 | 210 |
GO:001063926 | Thyroid | ATC | negative regulation of organelle organization | 179/6293 | 348/18723 | 3.74e-12 | 1.50e-10 | 179 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CORO1B | SNV | Missense_Mutation | c.1385N>A | p.Ala462Asp | p.A462D | Q9BR76 | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD | |
CORO1B | SNV | Missense_Mutation | rs757671047 | c.209N>A | p.Arg70His | p.R70H | Q9BR76 | protein_coding | deleterious(0.02) | possibly_damaging(0.684) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | c.619N>T | p.Arg207Trp | p.R207W | Q9BR76 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
CORO1B | SNV | Missense_Mutation | rs767771419 | c.1003G>A | p.Ala335Thr | p.A335T | Q9BR76 | protein_coding | tolerated(0.07) | benign(0.281) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | rs772528176 | c.1148N>A | p.Arg383Gln | p.R383Q | Q9BR76 | protein_coding | tolerated(0.39) | benign(0) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | rs769428845 | c.286N>A | p.Glu96Lys | p.E96K | Q9BR76 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CORO1B | SNV | Missense_Mutation | c.517N>G | p.Ser173Gly | p.S173G | Q9BR76 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-AH-6897-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CORO1B | insertion | In_Frame_Ins | novel | c.562_563insTCAGCTGGAACCACAATG | p.Val182_Asn187dup | p.V182_N187dup | Q9BR76 | protein_coding | TCGA-G5-6233-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | ||
CORO1B | SNV | Missense_Mutation | novel | c.81N>T | p.Glu27Asp | p.E27D | Q9BR76 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CORO1B | SNV | Missense_Mutation | novel | c.236N>A | p.Cys79Tyr | p.C79Y | Q9BR76 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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