![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ADAM10 |
Gene summary for ADAM10 |
![]() |
Gene information | Species | Human | Gene symbol | ADAM10 | Gene ID | 102 |
Gene name | ADAM metallopeptidase domain 10 | |
Gene Alias | AD10 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R5U5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
102 | ADAM10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.03e-14 | -5.32e-01 | 0.0155 |
102 | ADAM10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.21e-06 | -5.43e-01 | -0.1207 |
102 | ADAM10 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.68e-05 | -4.60e-01 | -0.0842 |
102 | ADAM10 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.32e-07 | -4.23e-01 | 0.096 |
102 | ADAM10 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.39e-02 | -4.91e-01 | 0.0528 |
102 | ADAM10 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.85e-03 | -4.43e-01 | -0.0177 |
102 | ADAM10 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.20e-05 | -3.99e-01 | 0.0338 |
102 | ADAM10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.27e-11 | -4.83e-01 | 0.0674 |
102 | ADAM10 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.92e-04 | -4.24e-01 | 0.0588 |
102 | ADAM10 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.31e-07 | -3.72e-01 | 0.294 |
102 | ADAM10 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.17e-10 | -4.85e-01 | 0.3859 |
102 | ADAM10 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.34e-03 | -5.24e-01 | 0.2585 |
102 | ADAM10 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.11e-06 | -4.49e-01 | 0.3005 |
102 | ADAM10 | A001-C-207 | Human | Colorectum | FAP | 8.24e-04 | -1.67e-01 | 0.1278 |
102 | ADAM10 | A015-C-203 | Human | Colorectum | FAP | 1.86e-24 | -2.98e-01 | -0.1294 |
102 | ADAM10 | A015-C-204 | Human | Colorectum | FAP | 1.00e-05 | -2.00e-01 | -0.0228 |
102 | ADAM10 | A014-C-040 | Human | Colorectum | FAP | 4.12e-03 | -1.66e-01 | -0.1184 |
102 | ADAM10 | A002-C-201 | Human | Colorectum | FAP | 6.65e-14 | -1.81e-01 | 0.0324 |
102 | ADAM10 | A002-C-203 | Human | Colorectum | FAP | 3.01e-05 | -1.33e-01 | 0.2786 |
102 | ADAM10 | A001-C-119 | Human | Colorectum | FAP | 8.50e-06 | -1.14e-01 | -0.1557 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000155824 | Skin | cSCC | regulation of cell growth | 140/4864 | 414/18723 | 2.07e-04 | 1.72e-03 | 140 |
GO:003461226 | Skin | cSCC | response to tumor necrosis factor | 88/4864 | 253/18723 | 1.11e-03 | 7.31e-03 | 88 |
GO:006099622 | Skin | cSCC | dendritic spine development | 40/4864 | 99/18723 | 1.18e-03 | 7.70e-03 | 40 |
GO:00469317 | Skin | cSCC | pore complex assembly | 12/4864 | 20/18723 | 1.34e-03 | 8.54e-03 | 12 |
GO:003030722 | Skin | cSCC | positive regulation of cell growth | 61/4864 | 166/18723 | 1.39e-03 | 8.78e-03 | 61 |
GO:00164858 | Skin | cSCC | protein processing | 79/4864 | 225/18723 | 1.43e-03 | 9.02e-03 | 79 |
GO:001097522 | Skin | cSCC | regulation of neuron projection development | 141/4864 | 445/18723 | 3.72e-03 | 1.99e-02 | 141 |
GO:004521627 | Skin | cSCC | cell-cell junction organization | 69/4864 | 200/18723 | 4.46e-03 | 2.29e-02 | 69 |
GO:00336196 | Skin | cSCC | membrane protein proteolysis | 24/4864 | 57/18723 | 5.80e-03 | 2.87e-02 | 24 |
GO:000721922 | Skin | cSCC | Notch signaling pathway | 60/4864 | 172/18723 | 5.82e-03 | 2.87e-02 | 60 |
GO:19019988 | Skin | cSCC | toxin transport | 18/4864 | 40/18723 | 7.10e-03 | 3.40e-02 | 18 |
GO:000716224 | Skin | cSCC | negative regulation of cell adhesion | 98/4864 | 303/18723 | 7.45e-03 | 3.50e-02 | 98 |
GO:004592719 | Skin | cSCC | positive regulation of growth | 85/4864 | 259/18723 | 8.03e-03 | 3.73e-02 | 85 |
GO:004298713 | Skin | cSCC | amyloid precursor protein catabolic process | 27/4864 | 68/18723 | 9.07e-03 | 4.16e-02 | 27 |
GO:006100113 | Skin | cSCC | regulation of dendritic spine morphogenesis | 20/4864 | 47/18723 | 9.84e-03 | 4.34e-02 | 20 |
GO:0022411113 | Thyroid | PTC | cellular component disassembly | 232/5968 | 443/18723 | 1.36e-19 | 1.75e-17 | 232 |
GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
GO:0016049112 | Thyroid | PTC | cell growth | 225/5968 | 482/18723 | 4.75e-12 | 2.07e-10 | 225 |
GO:0001701111 | Thyroid | PTC | in utero embryonic development | 175/5968 | 367/18723 | 1.40e-10 | 4.73e-09 | 175 |
GO:0001558111 | Thyroid | PTC | regulation of cell growth | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa050102 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050103 | Colorectum | SER | Alzheimer disease | 146/1580 | 384/8465 | 6.52e-20 | 2.40e-18 | 1.75e-18 | 146 |
hsa050108 | Colorectum | FAP | Alzheimer disease | 105/1404 | 384/8465 | 3.74e-08 | 1.04e-06 | 6.33e-07 | 105 |
hsa050109 | Colorectum | FAP | Alzheimer disease | 105/1404 | 384/8465 | 3.74e-08 | 1.04e-06 | 6.33e-07 | 105 |
hsa0501014 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa051204 | Liver | Cirrhotic | Epithelial cell signaling in Helicobacter pylori infection | 34/2530 | 70/8465 | 7.42e-04 | 4.33e-03 | 2.67e-03 | 34 |
hsa0501015 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa0512011 | Liver | Cirrhotic | Epithelial cell signaling in Helicobacter pylori infection | 34/2530 | 70/8465 | 7.42e-04 | 4.33e-03 | 2.67e-03 | 34 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa051202 | Liver | HCC | Epithelial cell signaling in Helicobacter pylori infection | 50/4020 | 70/8465 | 3.96e-05 | 2.16e-04 | 1.20e-04 | 50 |
hsa0501032 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa051203 | Liver | HCC | Epithelial cell signaling in Helicobacter pylori infection | 50/4020 | 70/8465 | 3.96e-05 | 2.16e-04 | 1.20e-04 | 50 |
hsa0501062 | Oral cavity | NEOLP | Alzheimer disease | 97/1112 | 384/8465 | 3.97e-11 | 1.57e-09 | 9.89e-10 | 97 |
hsa0501072 | Oral cavity | NEOLP | Alzheimer disease | 97/1112 | 384/8465 | 3.97e-11 | 1.57e-09 | 9.89e-10 | 97 |
hsa0501026 | Prostate | BPH | Alzheimer disease | 165/1718 | 384/8465 | 4.03e-25 | 1.66e-23 | 1.03e-23 | 165 |
hsa051209 | Prostate | BPH | Epithelial cell signaling in Helicobacter pylori infection | 29/1718 | 70/8465 | 4.25e-05 | 2.98e-04 | 1.85e-04 | 29 |
hsa05010111 | Prostate | BPH | Alzheimer disease | 165/1718 | 384/8465 | 4.03e-25 | 1.66e-23 | 1.03e-23 | 165 |
hsa0512016 | Prostate | BPH | Epithelial cell signaling in Helicobacter pylori infection | 29/1718 | 70/8465 | 4.25e-05 | 2.98e-04 | 1.85e-04 | 29 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAM10 | SNV | Missense_Mutation | novel | c.1712N>G | p.Ile571Ser | p.I571S | O14672 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
ADAM10 | SNV | Missense_Mutation | c.292G>C | p.Asp98His | p.D98H | O14672 | protein_coding | deleterious(0.01) | probably_damaging(0.948) | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAM10 | SNV | Missense_Mutation | novel | c.1564N>A | p.Glu522Lys | p.E522K | O14672 | protein_coding | tolerated(0.49) | benign(0.01) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
ADAM10 | SNV | Missense_Mutation | c.313G>A | p.Gly105Arg | p.G105R | O14672 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ADAM10 | SNV | Missense_Mutation | rs371036827 | c.523G>A | p.Asp175Asn | p.D175N | O14672 | protein_coding | tolerated(0.09) | benign(0.097) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ADAM10 | SNV | Missense_Mutation | novel | c.740N>T | p.Ser247Phe | p.S247F | O14672 | protein_coding | deleterious(0) | possibly_damaging(0.593) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ADAM10 | SNV | Missense_Mutation | c.166N>A | p.Glu56Lys | p.E56K | O14672 | protein_coding | tolerated(0.57) | benign(0.216) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
ADAM10 | SNV | Missense_Mutation | c.1207N>C | p.Glu403Gln | p.E403Q | O14672 | protein_coding | tolerated(0.07) | probably_damaging(0.925) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ADAM10 | SNV | Missense_Mutation | c.779N>T | p.Thr260Ile | p.T260I | O14672 | protein_coding | deleterious(0.01) | possibly_damaging(0.517) | TCGA-A6-2680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADAM10 | SNV | Missense_Mutation | c.883N>G | p.Ile295Val | p.I295V | O14672 | protein_coding | tolerated(0.1) | benign(0.206) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
102 | ADAM10 | ENZYME, CELL SURFACE, TRANSPORTER, NEUTRAL ZINC METALLOPEPTIDASE, DRUGGABLE GENOME, PROTEASE | inhibitor | 348353646 | ||
102 | ADAM10 | ENZYME, CELL SURFACE, TRANSPORTER, NEUTRAL ZINC METALLOPEPTIDASE, DRUGGABLE GENOME, PROTEASE | inhibitor | 178103981 | ILOMASTAT | |
102 | ADAM10 | ENZYME, CELL SURFACE, TRANSPORTER, NEUTRAL ZINC METALLOPEPTIDASE, DRUGGABLE GENOME, PROTEASE | INCB7839 | |||
102 | ADAM10 | ENZYME, CELL SURFACE, TRANSPORTER, NEUTRAL ZINC METALLOPEPTIDASE, DRUGGABLE GENOME, PROTEASE | inhibitor | 252166769 | ||
102 | ADAM10 | ENZYME, CELL SURFACE, TRANSPORTER, NEUTRAL ZINC METALLOPEPTIDASE, DRUGGABLE GENOME, PROTEASE | MARIMASTAT | MARIMASTAT | 26192023 | |
102 | ADAM10 | ENZYME, CELL SURFACE, TRANSPORTER, NEUTRAL ZINC METALLOPEPTIDASE, DRUGGABLE GENOME, PROTEASE | Aderbasib | ADERBASIB |
Page: 1 |