Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: UBR5

Gene summary for UBR5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

UBR5

Gene ID

51366

Gene nameubiquitin protein ligase E3 component n-recognin 5
Gene AliasDD5
Cytomap8q22.3
Gene Typeprotein-coding
GO ID

GO:0000209

UniProtAcc

O95071


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51366UBR5CA_HPV_1HumanCervixCC2.52e-04-5.12e-020.0264
51366UBR5CCI_1HumanCervixCC8.71e-081.10e+000.528
51366UBR5CCI_2HumanCervixCC1.00e-141.95e+000.5249
51366UBR5CCI_3HumanCervixCC1.26e-131.23e+000.516
51366UBR5HTA11_3410_2000001011HumanColorectumAD2.24e-21-6.76e-010.0155
51366UBR5HTA11_2487_2000001011HumanColorectumSER3.81e-04-4.76e-01-0.1808
51366UBR5HTA11_2951_2000001011HumanColorectumAD3.06e-03-7.44e-010.0216
51366UBR5HTA11_3361_2000001011HumanColorectumAD2.02e-09-7.07e-01-0.1207
51366UBR5HTA11_696_2000001011HumanColorectumAD1.20e-12-4.54e-01-0.1464
51366UBR5HTA11_866_2000001011HumanColorectumAD2.33e-08-3.76e-01-0.1001
51366UBR5HTA11_5216_2000001011HumanColorectumSER3.40e-02-5.05e-01-0.1462
51366UBR5HTA11_7862_2000001011HumanColorectumAD1.03e-03-6.23e-01-0.0179
51366UBR5HTA11_866_3004761011HumanColorectumAD1.22e-15-6.61e-010.096
51366UBR5HTA11_8622_2000001021HumanColorectumSER6.08e-04-6.69e-010.0528
51366UBR5HTA11_10623_2000001011HumanColorectumAD2.15e-02-5.58e-01-0.0177
51366UBR5HTA11_10711_2000001011HumanColorectumAD8.44e-07-5.67e-010.0338
51366UBR5HTA11_7696_3000711011HumanColorectumAD4.32e-15-5.39e-010.0674
51366UBR5HTA11_6818_2000001021HumanColorectumAD1.64e-03-4.86e-010.0588
51366UBR5HTA11_99999970781_79442HumanColorectumMSS2.20e-08-3.47e-010.294
51366UBR5HTA11_99999973899_84307HumanColorectumMSS3.81e-06-6.60e-010.2585
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00323866LiverNAFLDregulation of intracellular transport49/1882337/187235.34e-034.11e-0249
GO:00165743LiverNAFLDhistone ubiquitination11/188247/187235.92e-034.47e-0211
GO:19033217LiverNAFLDnegative regulation of protein modification by small protein conjugation or removal18/188295/187236.05e-034.54e-0218
GO:00323886LiverNAFLDpositive regulation of intracellular transport32/1882202/187236.42e-034.69e-0232
GO:19038297LiverNAFLDpositive regulation of cellular protein localization41/1882276/187237.11e-034.95e-0241
GO:007259412LiverCirrhoticestablishment of protein localization to organelle189/4634422/187231.01e-192.45e-17189
GO:003238611LiverCirrhoticregulation of intracellular transport147/4634337/187231.84e-141.72e-12147
GO:004854512LiverCirrhoticresponse to steroid hormone146/4634339/187237.87e-146.76e-12146
GO:003315711LiverCirrhoticregulation of intracellular protein transport108/4634229/187231.23e-131.04e-11108
GO:190382912LiverCirrhoticpositive regulation of cellular protein localization123/4634276/187234.06e-133.22e-11123
GO:190495112LiverCirrhoticpositive regulation of establishment of protein localization135/4634319/187233.20e-122.28e-10135
GO:005122212LiverCirrhoticpositive regulation of protein transport126/4634303/187236.85e-113.77e-09126
GO:003238811LiverCirrhoticpositive regulation of intracellular transport92/4634202/187238.60e-114.66e-0992
GO:009031611LiverCirrhoticpositive regulation of intracellular protein transport77/4634160/187231.17e-106.21e-0977
GO:190332012LiverCirrhoticregulation of protein modification by small protein conjugation or removal105/4634242/187231.43e-107.43e-09105
GO:007138312LiverCirrhoticcellular response to steroid hormone stimulus90/4634204/187231.04e-094.70e-0890
GO:003139612LiverCirrhoticregulation of protein ubiquitination89/4634210/187231.40e-085.30e-0789
GO:000691312LiverCirrhoticnucleocytoplasmic transport118/4634301/187231.71e-086.27e-07118
GO:005116912LiverCirrhoticnuclear transport118/4634301/187231.71e-086.27e-07118
GO:003450411LiverCirrhoticprotein localization to nucleus113/4634290/187235.00e-081.58e-06113
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0412014CervixCCUbiquitin mediated proteolysis49/1267142/84654.26e-097.68e-084.54e-0849
hsa0412015CervixCCUbiquitin mediated proteolysis49/1267142/84654.26e-097.68e-084.54e-0849
hsa04120ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa041201ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa041202ColorectumSERUbiquitin mediated proteolysis39/1580142/84656.18e-033.66e-022.66e-0239
hsa041203ColorectumSERUbiquitin mediated proteolysis39/1580142/84656.18e-033.66e-022.66e-0239
hsa041204ColorectumMSSUbiquitin mediated proteolysis55/1875142/84655.02e-066.00e-053.68e-0555
hsa041205ColorectumMSSUbiquitin mediated proteolysis55/1875142/84655.02e-066.00e-053.68e-0555
hsa041206ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041207ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041208ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa041209ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa0412016EndometriumAEHUbiquitin mediated proteolysis41/1197142/84653.42e-064.27e-053.13e-0541
hsa0412017EndometriumAEHUbiquitin mediated proteolysis41/1197142/84653.42e-064.27e-053.13e-0541
hsa0412023EndometriumEECUbiquitin mediated proteolysis41/1237142/84657.86e-069.58e-057.14e-0541
hsa0412033EndometriumEECUbiquitin mediated proteolysis41/1237142/84657.86e-069.58e-057.14e-0541
hsa0412026EsophagusHGINUbiquitin mediated proteolysis49/1383142/84657.78e-081.33e-061.06e-0649
hsa04120111EsophagusHGINUbiquitin mediated proteolysis49/1383142/84657.78e-081.33e-061.06e-0649
hsa0412027EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
hsa0412036EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
UBR5SNVMissense_Mutationnovelc.5624N>Tp.Ser1875Phep.S1875FO95071protein_codingdeleterious(0)probably_damaging(0.974)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
UBR5SNVMissense_Mutationnovelc.5161A>Cp.Thr1721Prop.T1721PO95071protein_codingtolerated(0.08)benign(0)TCGA-A2-A0CW-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
UBR5SNVMissense_Mutationc.1608N>Tp.Leu536Phep.L536FO95071protein_codingdeleterious(0.01)possibly_damaging(0.656)TCGA-A7-A0D9-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereSD
UBR5SNVMissense_Mutationnovelc.1367C>Tp.Ser456Phep.S456FO95071protein_codingtolerated(0.12)benign(0.094)TCGA-A8-A06U-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
UBR5SNVMissense_Mutationc.7679N>Tp.Gly2560Valp.G2560VO95071protein_codingdeleterious(0)possibly_damaging(0.908)TCGA-A8-A08R-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
UBR5SNVMissense_Mutationnovelc.5161N>Cp.Thr1721Prop.T1721PO95071protein_codingtolerated(0.08)benign(0)TCGA-A8-A097-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
UBR5SNVMissense_Mutationc.1795N>Cp.Lys599Glnp.K599QO95071protein_codingtolerated(0.07)probably_damaging(0.95)TCGA-A8-A09Q-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozoleSD
UBR5SNVMissense_Mutationnovelc.2473N>Tp.Asp825Tyrp.D825YO95071protein_codingdeleterious(0)probably_damaging(0.99)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
UBR5SNVMissense_Mutationc.6185N>Ap.Arg2062Lysp.R2062KO95071protein_codingtolerated(0.19)possibly_damaging(0.815)TCGA-AO-A0J9-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamidePD
UBR5SNVMissense_Mutationnovelc.5161N>Cp.Thr1721Prop.T1721PO95071protein_codingtolerated(0.08)benign(0)TCGA-AO-A12H-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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