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Gene: TTN |
Gene summary for TTN |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TTN | Gene ID | 7273 |
| Gene name | titin | |
| Gene Alias | CMD1G | |
| Cytomap | 2q31.2 | |
| Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q8WZ42 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7273 | TTN | HCC1_Meng | Human | Liver | HCC | 1.93e-02 | -1.44e-01 | 0.0246 |
| 7273 | TTN | HCC5 | Human | Liver | HCC | 6.34e-15 | 2.72e+00 | 0.4932 |
| 7273 | TTN | S028 | Human | Liver | HCC | 7.08e-10 | 6.89e-01 | 0.2503 |
| 7273 | TTN | S029 | Human | Liver | HCC | 1.04e-02 | 3.61e-01 | 0.2581 |
| 7273 | TTN | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.80e-10 | 5.59e-01 | -0.2116 |
| 7273 | TTN | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.21e-06 | 7.26e-01 | -0.1941 |
| 7273 | TTN | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.26e-07 | 6.77e-01 | -0.2107 |
| 7273 | TTN | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.27e-10 | 6.99e-01 | -0.2119 |
| 7273 | TTN | HTA12-18-3 | Human | Pancreas | PDAC | 1.07e-02 | 5.78e-01 | 0.0716 |
| 7273 | TTN | HTA12-25-1 | Human | Pancreas | PDAC | 2.02e-02 | 4.06e-01 | 0.313 |
| 7273 | TTN | HTA12-26-1 | Human | Pancreas | PDAC | 1.84e-07 | 4.56e-01 | 0.3728 |
| 7273 | TTN | HTA12-29-1 | Human | Pancreas | PDAC | 3.65e-29 | 6.66e-01 | 0.3722 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000704412 | Liver | Cirrhotic | cell-substrate junction assembly | 46/4634 | 95/18723 | 4.89e-07 | 1.10e-05 | 46 |
| GO:000815412 | Liver | Cirrhotic | actin polymerization or depolymerization | 86/4634 | 218/18723 | 1.04e-06 | 2.13e-05 | 86 |
| GO:00108216 | Liver | Cirrhotic | regulation of mitochondrion organization | 62/4634 | 144/18723 | 1.09e-06 | 2.22e-05 | 62 |
| GO:003004112 | Liver | Cirrhotic | actin filament polymerization | 77/4634 | 191/18723 | 1.41e-06 | 2.79e-05 | 77 |
| GO:003253512 | Liver | Cirrhotic | regulation of cellular component size | 135/4634 | 383/18723 | 2.32e-06 | 4.26e-05 | 135 |
| GO:005149512 | Liver | Cirrhotic | positive regulation of cytoskeleton organization | 87/4634 | 226/18723 | 2.96e-06 | 5.25e-05 | 87 |
| GO:003158912 | Liver | Cirrhotic | cell-substrate adhesion | 128/4634 | 363/18723 | 4.10e-06 | 6.90e-05 | 128 |
| GO:004804111 | Liver | Cirrhotic | focal adhesion assembly | 41/4634 | 87/18723 | 4.78e-06 | 7.86e-05 | 41 |
| GO:003083312 | Liver | Cirrhotic | regulation of actin filament polymerization | 69/4634 | 172/18723 | 5.92e-06 | 9.65e-05 | 69 |
| GO:003227312 | Liver | Cirrhotic | positive regulation of protein polymerization | 58/4634 | 138/18723 | 5.96e-06 | 9.69e-05 | 58 |
| GO:00080647 | Liver | Cirrhotic | regulation of actin polymerization or depolymerization | 74/4634 | 188/18723 | 6.26e-06 | 9.92e-05 | 74 |
| GO:20012377 | Liver | Cirrhotic | negative regulation of extrinsic apoptotic signaling pathway | 44/4634 | 97/18723 | 7.61e-06 | 1.15e-04 | 44 |
| GO:00308327 | Liver | Cirrhotic | regulation of actin filament length | 74/4634 | 189/18723 | 7.83e-06 | 1.18e-04 | 74 |
| GO:000689811 | Liver | Cirrhotic | receptor-mediated endocytosis | 91/4634 | 244/18723 | 8.13e-06 | 1.22e-04 | 91 |
| GO:001604911 | Liver | Cirrhotic | cell growth | 160/4634 | 482/18723 | 1.50e-05 | 2.07e-04 | 160 |
| GO:009758111 | Liver | Cirrhotic | lamellipodium organization | 40/4634 | 90/18723 | 3.48e-05 | 4.26e-04 | 40 |
| GO:000716011 | Liver | Cirrhotic | cell-matrix adhesion | 85/4634 | 233/18723 | 4.06e-05 | 4.83e-04 | 85 |
| GO:19031465 | Liver | Cirrhotic | regulation of autophagy of mitochondrion | 18/4634 | 33/18723 | 2.33e-04 | 2.11e-03 | 18 |
| GO:00308387 | Liver | Cirrhotic | positive regulation of actin filament polymerization | 40/4634 | 99/18723 | 4.21e-04 | 3.46e-03 | 40 |
| GO:000155811 | Liver | Cirrhotic | regulation of cell growth | 132/4634 | 414/18723 | 5.53e-04 | 4.36e-03 | 132 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa054142 | Lung | AIS | Dilated cardiomyopathy | 22/961 | 96/8465 | 9.02e-04 | 7.11e-03 | 4.55e-03 | 22 |
| hsa054102 | Lung | AIS | Hypertrophic cardiomyopathy | 20/961 | 90/8465 | 2.25e-03 | 1.37e-02 | 8.80e-03 | 20 |
| hsa054143 | Lung | AIS | Dilated cardiomyopathy | 22/961 | 96/8465 | 9.02e-04 | 7.11e-03 | 4.55e-03 | 22 |
| hsa054103 | Lung | AIS | Hypertrophic cardiomyopathy | 20/961 | 90/8465 | 2.25e-03 | 1.37e-02 | 8.80e-03 | 20 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TTN | SNV | Missense_Mutation | rs557526069 | c.35041G>A | p.Glu11681Lys | p.E11681K | protein_coding | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |||
| TTN | SNV | Missense_Mutation | novel | c.31372N>C | p.Val10458Leu | p.V10458L | protein_coding | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
| TTN | SNV | Missense_Mutation | c.69142N>A | p.Glu23048Lys | p.E23048K | protein_coding | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||||
| TTN | SNV | Missense_Mutation | novel | c.105331G>C | p.Glu35111Gln | p.E35111Q | protein_coding | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |||
| TTN | SNV | Missense_Mutation | novel | c.91713G>A | p.Met30571Ile | p.M30571I | protein_coding | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |||
| TTN | SNV | Missense_Mutation | c.31520A>T | p.Glu10507Val | p.E10507V | protein_coding | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |||||
| TTN | SNV | Missense_Mutation | novel | c.43021N>A | p.Glu14341Lys | p.E14341K | protein_coding | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |||
| TTN | SNV | Missense_Mutation | c.58960N>T | p.Val19654Phe | p.V19654F | protein_coding | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | ||||
| TTN | SNV | Missense_Mutation | novel | c.38183N>T | p.Lys12728Ile | p.K12728I | protein_coding | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |||
| TTN | SNV | Missense_Mutation | novel | c.10739C>G | p.Ala3580Gly | p.A3580G | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 7273 | TTN | DRUGGABLE GENOME, TYROSINE KINASE, SERINE THREONINE KINASE, KINASE, ENZYME | PROTEASE INHIBITORS | 9648223 |
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