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Gene: SRF |
Gene summary for SRF |
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Gene information | Species | Human | Gene symbol | SRF | Gene ID | 6722 |
Gene name | serum response factor | |
Gene Alias | MCM1 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B4DU24 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6722 | SRF | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.08e-04 | 3.42e-01 | -0.0811 |
6722 | SRF | HTA11_696_2000001011 | Human | Colorectum | AD | 7.01e-05 | 2.10e-01 | -0.1464 |
6722 | SRF | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.39e-10 | 3.69e-01 | -0.059 |
6722 | SRF | HTA11_866_3004761011 | Human | Colorectum | AD | 3.51e-03 | 2.42e-01 | 0.096 |
6722 | SRF | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.53e-07 | 2.32e-01 | 0.0674 |
6722 | SRF | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.59e-15 | 4.12e-01 | 0.294 |
6722 | SRF | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.38e-24 | 5.53e-01 | 0.3859 |
6722 | SRF | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.97e-09 | 4.77e-01 | 0.2585 |
6722 | SRF | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.10e-04 | 1.99e-01 | 0.3005 |
6722 | SRF | LZE8T | Human | Esophagus | ESCC | 1.64e-04 | 4.89e-02 | 0.067 |
6722 | SRF | LZE20T | Human | Esophagus | ESCC | 2.83e-02 | -4.23e-02 | 0.0662 |
6722 | SRF | LZE24T | Human | Esophagus | ESCC | 8.90e-06 | 2.54e-01 | 0.0596 |
6722 | SRF | P2T-E | Human | Esophagus | ESCC | 4.47e-11 | 9.40e-02 | 0.1177 |
6722 | SRF | P4T-E | Human | Esophagus | ESCC | 6.97e-14 | 2.19e-01 | 0.1323 |
6722 | SRF | P5T-E | Human | Esophagus | ESCC | 2.95e-12 | 9.77e-02 | 0.1327 |
6722 | SRF | P8T-E | Human | Esophagus | ESCC | 7.41e-05 | 3.32e-02 | 0.0889 |
6722 | SRF | P9T-E | Human | Esophagus | ESCC | 1.03e-09 | 1.76e-02 | 0.1131 |
6722 | SRF | P10T-E | Human | Esophagus | ESCC | 5.36e-14 | 1.43e-01 | 0.116 |
6722 | SRF | P11T-E | Human | Esophagus | ESCC | 5.84e-06 | 3.81e-02 | 0.1426 |
6722 | SRF | P12T-E | Human | Esophagus | ESCC | 4.59e-14 | 1.82e-02 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:01200346 | Oral cavity | OSCC | positive regulation of plasma membrane bounded cell projection assembly | 55/7305 | 105/18723 | 3.64e-03 | 1.51e-02 | 55 |
GO:004521618 | Oral cavity | OSCC | cell-cell junction organization | 97/7305 | 200/18723 | 3.83e-03 | 1.57e-02 | 97 |
GO:00603484 | Oral cavity | OSCC | bone development | 99/7305 | 205/18723 | 4.13e-03 | 1.68e-02 | 99 |
GO:00426927 | Oral cavity | OSCC | muscle cell differentiation | 175/7305 | 384/18723 | 4.79e-03 | 1.92e-02 | 175 |
GO:003432916 | Oral cavity | OSCC | cell junction assembly | 190/7305 | 420/18723 | 4.99e-03 | 1.96e-02 | 190 |
GO:00604256 | Oral cavity | OSCC | lung morphogenesis | 29/7305 | 50/18723 | 5.01e-03 | 1.96e-02 | 29 |
GO:00486759 | Oral cavity | OSCC | axon extension | 61/7305 | 120/18723 | 5.52e-03 | 2.14e-02 | 61 |
GO:00987513 | Oral cavity | OSCC | bone cell development | 21/7305 | 34/18723 | 6.02e-03 | 2.28e-02 | 21 |
GO:00147067 | Oral cavity | OSCC | striated muscle tissue development | 174/7305 | 384/18723 | 6.45e-03 | 2.40e-02 | 174 |
GO:00605629 | Oral cavity | OSCC | epithelial tube morphogenesis | 149/7305 | 325/18723 | 6.73e-03 | 2.50e-02 | 149 |
GO:0035855 | Oral cavity | OSCC | megakaryocyte development | 12/7305 | 17/18723 | 8.40e-03 | 3.05e-02 | 12 |
GO:00903983 | Oral cavity | OSCC | cellular senescence | 48/7305 | 93/18723 | 9.03e-03 | 3.26e-02 | 48 |
GO:00615153 | Oral cavity | OSCC | myeloid cell development | 38/7305 | 71/18723 | 9.12e-03 | 3.27e-02 | 38 |
GO:003103217 | Oral cavity | OSCC | actomyosin structure organization | 93/7305 | 196/18723 | 9.63e-03 | 3.41e-02 | 93 |
GO:00075969 | Oral cavity | OSCC | blood coagulation | 102/7305 | 217/18723 | 9.69e-03 | 3.43e-02 | 102 |
GO:00600553 | Oral cavity | OSCC | angiogenesis involved in wound healing | 19/7305 | 31/18723 | 9.93e-03 | 3.48e-02 | 19 |
GO:00602611 | Oral cavity | OSCC | positive regulation of transcription initiation from RNA polymerase II promoter | 16/7305 | 25/18723 | 1.00e-02 | 3.49e-02 | 16 |
GO:00335614 | Oral cavity | OSCC | regulation of water loss via skin | 17/7305 | 27/18723 | 1.01e-02 | 3.49e-02 | 17 |
GO:006156410 | Oral cavity | OSCC | axon development | 207/7305 | 467/18723 | 1.01e-02 | 3.51e-02 | 207 |
GO:00022445 | Oral cavity | OSCC | hematopoietic progenitor cell differentiation | 57/7305 | 114/18723 | 1.09e-02 | 3.71e-02 | 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05166 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa051661 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa051662 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa04022 | Colorectum | MSS | cGMP-PKG signaling pathway | 51/1875 | 167/8465 | 6.83e-03 | 2.73e-02 | 1.67e-02 | 51 |
hsa051663 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa040221 | Colorectum | MSS | cGMP-PKG signaling pathway | 51/1875 | 167/8465 | 6.83e-03 | 2.73e-02 | 1.67e-02 | 51 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0401014 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa05166113 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0401015 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
SRF | STM | Thyroid | ADJ | TFCP2L1,AC016831.1,ST7-AS1, etc. | 5.35e-01 | ![]() |
SRF | STM | Thyroid | goiters | TFCP2L1,AC016831.1,ST7-AS1, etc. | 6.93e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRF | SNV | Missense_Mutation | novel | c.1081C>G | p.Gln361Glu | p.Q361E | P11831 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SRF | SNV | Missense_Mutation | novel | c.627G>C | p.Glu209Asp | p.E209D | P11831 | protein_coding | tolerated(0.14) | benign(0.269) | TCGA-BH-A0BF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SRF | SNV | Missense_Mutation | novel | c.1313N>T | p.Pro438Leu | p.P438L | P11831 | protein_coding | deleterious(0) | benign(0.015) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
SRF | SNV | Missense_Mutation | novel | c.857N>G | p.Ser286Cys | p.S286C | P11831 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
SRF | SNV | Missense_Mutation | novel | c.655C>A | p.Leu219Ile | p.L219I | P11831 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SRF | SNV | Missense_Mutation | rs761821794 | c.1174N>A | p.Ala392Thr | p.A392T | P11831 | protein_coding | tolerated(0.12) | probably_damaging(0.985) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SRF | SNV | Missense_Mutation | c.1036A>G | p.Met346Val | p.M346V | P11831 | protein_coding | tolerated(0.14) | possibly_damaging(0.878) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
SRF | SNV | Missense_Mutation | c.1504N>A | p.Ala502Thr | p.A502T | P11831 | protein_coding | tolerated_low_confidence(0.76) | benign(0) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SRF | SNV | Missense_Mutation | c.1328T>C | p.Val443Ala | p.V443A | P11831 | protein_coding | tolerated(0.1) | probably_damaging(0.956) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SRF | SNV | Missense_Mutation | c.1097C>T | p.Pro366Leu | p.P366L | P11831 | protein_coding | tolerated(0.08) | benign(0.115) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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