Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/SLPI_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SLPI_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SLPI_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SLPI_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/SLPI_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SLPI_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/SLPI_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SLPI_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SLPI_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SLPI_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SLPI_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SLPI_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SLPI_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0019731 | Stomach | GC | antibacterial humoral response | 13/1159 | 60/18723 | 6.18e-05 | 1.40e-03 | 13 |
GO:00190796 | Stomach | GC | viral genome replication | 20/1159 | 131/18723 | 1.59e-04 | 2.84e-03 | 20 |
GO:00433936 | Stomach | GC | regulation of protein binding | 25/1159 | 196/18723 | 4.72e-04 | 6.84e-03 | 25 |
GO:00507926 | Stomach | GC | regulation of viral process | 22/1159 | 164/18723 | 5.05e-04 | 7.16e-03 | 22 |
GO:19039006 | Stomach | GC | regulation of viral life cycle | 20/1159 | 148/18723 | 8.11e-04 | 1.02e-02 | 20 |
GO:0042742 | Stomach | GC | defense response to bacterium | 37/1159 | 350/18723 | 1.05e-03 | 1.23e-02 | 37 |
GO:00511005 | Stomach | GC | negative regulation of binding | 21/1159 | 162/18723 | 1.05e-03 | 1.24e-02 | 21 |
GO:00320913 | Stomach | GC | negative regulation of protein binding | 14/1159 | 94/18723 | 1.87e-03 | 1.93e-02 | 14 |
GO:00485253 | Stomach | GC | negative regulation of viral process | 13/1159 | 92/18723 | 4.27e-03 | 3.54e-02 | 13 |
GO:00450695 | Stomach | GC | regulation of viral genome replication | 12/1159 | 85/18723 | 5.97e-03 | 4.51e-02 | 12 |
GO:005254711 | Stomach | CAG with IM | regulation of peptidase activity | 61/1050 | 461/18723 | 3.60e-10 | 6.00e-08 | 61 |
GO:005254811 | Stomach | CAG with IM | regulation of endopeptidase activity | 58/1050 | 432/18723 | 5.62e-10 | 8.56e-08 | 58 |
GO:001603211 | Stomach | CAG with IM | viral process | 55/1050 | 415/18723 | 2.54e-09 | 2.88e-07 | 55 |
GO:001905811 | Stomach | CAG with IM | viral life cycle | 45/1050 | 317/18723 | 8.82e-09 | 7.70e-07 | 45 |
GO:004586111 | Stomach | CAG with IM | negative regulation of proteolysis | 45/1050 | 351/18723 | 1.90e-07 | 1.24e-05 | 45 |
GO:00197301 | Stomach | CAG with IM | antimicrobial humoral response | 23/1050 | 122/18723 | 2.62e-07 | 1.61e-05 | 23 |
GO:005109811 | Stomach | CAG with IM | regulation of binding | 45/1050 | 363/18723 | 4.99e-07 | 2.71e-05 | 45 |
GO:001046611 | Stomach | CAG with IM | negative regulation of peptidase activity | 35/1050 | 262/18723 | 1.66e-06 | 7.72e-05 | 35 |
GO:00109511 | Stomach | CAG with IM | negative regulation of endopeptidase activity | 34/1050 | 252/18723 | 1.86e-06 | 8.41e-05 | 34 |
GO:00069591 | Stomach | CAG with IM | humoral immune response | 39/1050 | 317/18723 | 3.43e-06 | 1.36e-04 | 39 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLPI | SNV | Missense_Mutation | novel | c.11N>A | p.Ser4Asn | p.S4N | P03973 | protein_coding | tolerated(0.21) | benign(0.026) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLPI | SNV | Missense_Mutation | | c.238A>G | p.Asn80Asp | p.N80D | P03973 | protein_coding | tolerated(0.29) | benign(0.015) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
SLPI | SNV | Missense_Mutation | novel | c.352T>C | p.Cys118Arg | p.C118R | P03973 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLPI | SNV | Missense_Mutation | | c.238N>C | p.Asn80His | p.N80H | P03973 | protein_coding | deleterious(0.03) | benign(0.188) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLPI | SNV | Missense_Mutation | novel | c.141G>T | p.Lys47Asn | p.K47N | P03973 | protein_coding | deleterious(0) | benign(0.001) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLPI | SNV | Missense_Mutation | novel | c.185G>T | p.Arg62Ile | p.R62I | P03973 | protein_coding | tolerated(0.11) | benign(0.062) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLPI | insertion | Frame_Shift_Ins | rs745834619 | c.306_307insC | p.Asn103GlnfsTer4 | p.N103Qfs*4 | P03973 | protein_coding | | | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SLPI | SNV | Missense_Mutation | novel | c.196N>A | p.Asp66Asn | p.D66N | P03973 | protein_coding | tolerated(0.09) | possibly_damaging(0.628) | TCGA-XR-A8TD-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SLPI | SNV | Missense_Mutation | | c.77N>G | p.Ser26Cys | p.S26C | P03973 | protein_coding | deleterious(0.01) | benign(0.24) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
SLPI | SNV | Missense_Mutation | novel | c.101T>A | p.Val34Asp | p.V34D | P03973 | protein_coding | tolerated(0.21) | possibly_damaging(0.472) | TCGA-52-7810-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |