Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PPIF_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PPIF_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PPIF_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PPIF_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PPIF_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PPIF_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PPIF_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004345715 | Thyroid | PTC | regulation of cellular respiration | 28/5968 | 49/18723 | 2.25e-04 | 1.64e-03 | 28 |
GO:000183625 | Thyroid | PTC | release of cytochrome c from mitochondria | 32/5968 | 59/18723 | 3.06e-04 | 2.14e-03 | 32 |
GO:00029314 | Thyroid | PTC | response to ischemia | 31/5968 | 58/18723 | 5.31e-04 | 3.41e-03 | 31 |
GO:00902006 | Thyroid | PTC | positive regulation of release of cytochrome c from mitochondria | 17/5968 | 28/18723 | 1.55e-03 | 8.63e-03 | 17 |
GO:005159219 | Thyroid | PTC | response to calcium ion | 65/5968 | 149/18723 | 1.67e-03 | 9.16e-03 | 65 |
GO:003579410 | Thyroid | PTC | positive regulation of mitochondrial membrane permeability | 23/5968 | 43/18723 | 2.66e-03 | 1.35e-02 | 23 |
GO:009019910 | Thyroid | PTC | regulation of release of cytochrome c from mitochondria | 25/5968 | 48/18723 | 2.86e-03 | 1.42e-02 | 25 |
GO:0071241110 | Thyroid | PTC | cellular response to inorganic substance | 92/5968 | 226/18723 | 3.01e-03 | 1.49e-02 | 92 |
GO:0051346112 | Thyroid | PTC | negative regulation of hydrolase activity | 146/5968 | 379/18723 | 3.33e-03 | 1.62e-02 | 146 |
GO:001082318 | Thyroid | PTC | negative regulation of mitochondrion organization | 25/5968 | 49/18723 | 4.09e-03 | 1.95e-02 | 25 |
GO:190268615 | Thyroid | PTC | mitochondrial outer membrane permeabilization involved in programmed cell death | 21/5968 | 40/18723 | 5.37e-03 | 2.47e-02 | 21 |
GO:00510518 | Thyroid | PTC | negative regulation of transport | 176/5968 | 470/18723 | 5.44e-03 | 2.49e-02 | 176 |
GO:190571010 | Thyroid | PTC | positive regulation of membrane permeability | 24/5968 | 48/18723 | 6.73e-03 | 2.90e-02 | 24 |
GO:00434629 | Thyroid | PTC | regulation of ATPase activity | 23/5968 | 46/18723 | 7.89e-03 | 3.33e-02 | 23 |
GO:00702656 | Thyroid | PTC | necrotic cell death | 29/5968 | 62/18723 | 9.96e-03 | 4.07e-02 | 29 |
GO:000208211 | Thyroid | PTC | regulation of oxidative phosphorylation | 13/5968 | 23/18723 | 1.25e-02 | 4.88e-02 | 13 |
GO:0071248110 | Thyroid | PTC | cellular response to metal ion | 78/5968 | 197/18723 | 1.29e-02 | 4.98e-02 | 78 |
GO:000645733 | Thyroid | ATC | protein folding | 140/6293 | 212/18723 | 3.46e-22 | 8.09e-20 | 140 |
GO:200123335 | Thyroid | ATC | regulation of apoptotic signaling pathway | 206/6293 | 356/18723 | 2.81e-21 | 5.92e-19 | 206 |
GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPIF | SNV | Missense_Mutation | novel | c.620N>A | p.Ser207Asn | p.S207N | P30405 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPIF | insertion | In_Frame_Ins | novel | c.618_619insCTTGTTCCTTTGACTCTTGACTCATCATTCATGACCGTT | p.Leu206_Ser207insLeuValProLeuThrLeuAspSerSerPheMetThrVal | p.L206_S207insLVPLTLDSSFMTV | P30405 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPIF | deletion | In_Frame_Del | novel | c.551_553delNNN | p.Ile184_Glu185delinsLys | p.I184_E185delinsK | P30405 | protein_coding | | | TCGA-E9-A5FK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | CR |
PPIF | SNV | Missense_Mutation | novel | c.228N>T | p.Glu76Asp | p.E76D | P30405 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPIF | SNV | Missense_Mutation | novel | c.365N>T | p.Gly122Val | p.G122V | P30405 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.995) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPIF | SNV | Missense_Mutation | rs145899672 | c.265N>A | p.Gly89Ser | p.G89S | P30405 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPIF | SNV | Missense_Mutation | rs371203826 | c.211G>A | p.Val71Ile | p.V71I | P30405 | protein_coding | deleterious_low_confidence(0.02) | benign(0.404) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
PPIF | SNV | Missense_Mutation | | c.569N>G | p.Lys190Arg | p.K190R | P30405 | protein_coding | tolerated_low_confidence(0.69) | benign(0.006) | TCGA-BS-A0TA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
PPIF | SNV | Missense_Mutation | rs771871615 | c.364G>A | p.Gly122Arg | p.G122R | P30405 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.654) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PPIF | SNV | Missense_Mutation | novel | c.280A>C | p.Thr94Pro | p.T94P | P30405 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.864) | TCGA-D1-A0ZP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |