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Gene: PLSCR1 |
Gene summary for PLSCR1 |
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Gene information | Species | Human | Gene symbol | PLSCR1 | Gene ID | 5359 |
Gene name | phospholipid scramblase 1 | |
Gene Alias | MMTRA1B | |
Cytomap | 3q24 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | O15162 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5359 | PLSCR1 | CA_HPV_1 | Human | Cervix | CC | 1.12e-05 | 3.42e-01 | 0.0264 |
5359 | PLSCR1 | CA_HPV_2 | Human | Cervix | CC | 2.97e-07 | 3.55e-01 | 0.0391 |
5359 | PLSCR1 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.24e-04 | 2.52e-01 | 0.0208 |
5359 | PLSCR1 | CCI_2 | Human | Cervix | CC | 1.67e-14 | 2.08e+00 | 0.5249 |
5359 | PLSCR1 | CCI_3 | Human | Cervix | CC | 5.22e-03 | 6.56e-01 | 0.516 |
5359 | PLSCR1 | Tumor | Human | Cervix | CC | 3.75e-37 | 7.32e-01 | 0.1241 |
5359 | PLSCR1 | sample3 | Human | Cervix | CC | 1.51e-48 | 8.09e-01 | 0.1387 |
5359 | PLSCR1 | H2 | Human | Cervix | HSIL_HPV | 9.92e-05 | 2.74e-01 | 0.0632 |
5359 | PLSCR1 | T3 | Human | Cervix | CC | 3.37e-46 | 8.09e-01 | 0.1389 |
5359 | PLSCR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.33e-11 | -5.09e-01 | 0.0155 |
5359 | PLSCR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.30e-05 | -4.14e-01 | -0.1464 |
5359 | PLSCR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.20e-02 | -3.08e-01 | -0.1001 |
5359 | PLSCR1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.12e-03 | -4.89e-01 | 0.0338 |
5359 | PLSCR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.50e-05 | -3.64e-01 | 0.0674 |
5359 | PLSCR1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.30e-11 | -4.83e-01 | 0.3005 |
5359 | PLSCR1 | F007 | Human | Colorectum | FAP | 1.35e-06 | -5.09e-01 | 0.1176 |
5359 | PLSCR1 | A001-C-207 | Human | Colorectum | FAP | 3.54e-02 | -2.79e-01 | 0.1278 |
5359 | PLSCR1 | A015-C-203 | Human | Colorectum | FAP | 9.96e-21 | -3.69e-01 | -0.1294 |
5359 | PLSCR1 | A015-C-204 | Human | Colorectum | FAP | 7.17e-06 | -3.95e-01 | -0.0228 |
5359 | PLSCR1 | A014-C-040 | Human | Colorectum | FAP | 1.98e-03 | -5.14e-01 | -0.1184 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0019079113 | Thyroid | PTC | viral genome replication | 74/5968 | 131/18723 | 4.85e-09 | 1.26e-07 | 74 |
GO:0042060112 | Thyroid | PTC | wound healing | 190/5968 | 422/18723 | 7.72e-09 | 1.92e-07 | 190 |
GO:0052126113 | Thyroid | PTC | movement in host environment | 91/5968 | 175/18723 | 2.41e-08 | 5.43e-07 | 91 |
GO:0050792113 | Thyroid | PTC | regulation of viral process | 85/5968 | 164/18723 | 8.33e-08 | 1.70e-06 | 85 |
GO:004578718 | Thyroid | PTC | positive regulation of cell cycle | 144/5968 | 313/18723 | 9.93e-08 | 1.99e-06 | 144 |
GO:000961520 | Thyroid | PTC | response to virus | 162/5968 | 367/18723 | 4.52e-07 | 7.41e-06 | 162 |
GO:1903900113 | Thyroid | PTC | regulation of viral life cycle | 72/5968 | 148/18723 | 1.49e-05 | 1.58e-04 | 72 |
GO:0010038112 | Thyroid | PTC | response to metal ion | 157/5968 | 373/18723 | 1.80e-05 | 1.86e-04 | 157 |
GO:00070595 | Thyroid | PTC | chromosome segregation | 146/5968 | 346/18723 | 2.99e-05 | 2.87e-04 | 146 |
GO:0044409113 | Thyroid | PTC | entry into host | 72/5968 | 151/18723 | 3.48e-05 | 3.29e-04 | 72 |
GO:0045069112 | Thyroid | PTC | regulation of viral genome replication | 45/5968 | 85/18723 | 4.46e-05 | 4.04e-04 | 45 |
GO:0046718112 | Thyroid | PTC | viral entry into host cell | 68/5968 | 144/18723 | 8.26e-05 | 7.00e-04 | 68 |
GO:000657513 | Thyroid | PTC | cellular modified amino acid metabolic process | 85/5968 | 188/18723 | 8.29e-05 | 7.01e-04 | 85 |
GO:009006816 | Thyroid | PTC | positive regulation of cell cycle process | 103/5968 | 236/18723 | 9.03e-05 | 7.50e-04 | 103 |
GO:000283114 | Thyroid | PTC | regulation of response to biotic stimulus | 136/5968 | 327/18723 | 1.22e-04 | 9.69e-04 | 136 |
GO:003210316 | Thyroid | PTC | positive regulation of response to external stimulus | 167/5968 | 427/18723 | 8.31e-04 | 5.13e-03 | 167 |
GO:004239813 | Thyroid | PTC | cellular modified amino acid biosynthetic process | 25/5968 | 46/18723 | 1.31e-03 | 7.43e-03 | 25 |
GO:00516077 | Thyroid | PTC | defense response to virus | 108/5968 | 265/18723 | 1.34e-03 | 7.55e-03 | 108 |
GO:01405467 | Thyroid | PTC | defense response to symbiont | 108/5968 | 265/18723 | 1.34e-03 | 7.55e-03 | 108 |
GO:00519835 | Thyroid | PTC | regulation of chromosome segregation | 43/5968 | 91/18723 | 1.53e-03 | 8.55e-03 | 43 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLSCR1 | SNV | Missense_Mutation | novel | c.19C>A | p.Gln7Lys | p.Q7K | O15162 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.522) | TCGA-LL-A50Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | CR |
PLSCR1 | insertion | Frame_Shift_Ins | novel | c.597_598insTGGAAACTAGGATTTCCAC | p.Gly200TrpfsTer29 | p.G200Wfs*29 | O15162 | protein_coding | TCGA-BH-A0DP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
PLSCR1 | SNV | Missense_Mutation | novel | c.506G>A | p.Gly169Asp | p.G169D | O15162 | protein_coding | tolerated(0.29) | probably_damaging(0.968) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PLSCR1 | SNV | Missense_Mutation | novel | c.820N>T | p.Ala274Ser | p.A274S | O15162 | protein_coding | tolerated(0.12) | benign(0.276) | TCGA-JW-A69B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PLSCR1 | SNV | Missense_Mutation | rs377240309 | c.837C>G | p.Ile279Met | p.I279M | O15162 | protein_coding | deleterious(0.01) | possibly_damaging(0.714) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
PLSCR1 | SNV | Missense_Mutation | c.761N>A | p.Cys254Tyr | p.C254Y | O15162 | protein_coding | tolerated(0.41) | benign(0) | TCGA-A6-2682-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5 | PD | |
PLSCR1 | SNV | Missense_Mutation | rs769076735 | c.452N>A | p.Arg151Gln | p.R151Q | O15162 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PLSCR1 | SNV | Missense_Mutation | novel | c.652N>G | p.Thr218Ala | p.T218A | O15162 | protein_coding | tolerated(0.08) | benign(0.381) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLSCR1 | SNV | Missense_Mutation | novel | c.850N>T | p.Asp284Tyr | p.D284Y | O15162 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PLSCR1 | SNV | Missense_Mutation | novel | c.392N>G | p.Ile131Ser | p.I131S | O15162 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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