Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PLEC_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PLEC_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PLEC_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/PLEC_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PLEC_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PLEC_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PLEC_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PLEC_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PLEC_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00616404 | Prostate | BPH | cytoskeleton-dependent cytokinesis | 31/3107 | 100/18723 | 2.63e-04 | 2.06e-03 | 31 |
GO:005087817 | Prostate | BPH | regulation of body fluid levels | 89/3107 | 379/18723 | 3.08e-04 | 2.37e-03 | 89 |
GO:00069972 | Prostate | BPH | nucleus organization | 38/3107 | 133/18723 | 3.69e-04 | 2.72e-03 | 38 |
GO:00712604 | Prostate | BPH | cellular response to mechanical stimulus | 26/3107 | 81/18723 | 4.39e-04 | 3.16e-03 | 26 |
GO:00096129 | Prostate | BPH | response to mechanical stimulus | 55/3107 | 216/18723 | 5.61e-04 | 3.91e-03 | 55 |
GO:00099138 | Prostate | BPH | epidermal cell differentiation | 52/3107 | 202/18723 | 5.95e-04 | 4.11e-03 | 52 |
GO:00426926 | Prostate | BPH | muscle cell differentiation | 88/3107 | 384/18723 | 7.59e-04 | 5.01e-03 | 88 |
GO:01201939 | Prostate | BPH | tight junction organization | 25/3107 | 80/18723 | 8.72e-04 | 5.62e-03 | 25 |
GO:00325064 | Prostate | BPH | cytokinetic process | 15/3107 | 39/18723 | 8.91e-04 | 5.72e-03 | 15 |
GO:00302165 | Prostate | BPH | keratinocyte differentiation | 38/3107 | 139/18723 | 9.35e-04 | 5.92e-03 | 38 |
GO:00107617 | Prostate | BPH | fibroblast migration | 17/3107 | 47/18723 | 9.41e-04 | 5.94e-03 | 17 |
GO:00011018 | Prostate | BPH | response to acid chemical | 37/3107 | 135/18723 | 1.03e-03 | 6.46e-03 | 37 |
GO:00352645 | Prostate | BPH | multicellular organism growth | 36/3107 | 132/18723 | 1.31e-03 | 7.90e-03 | 36 |
GO:0035051 | Prostate | BPH | cardiocyte differentiation | 40/3107 | 156/18723 | 2.58e-03 | 1.38e-02 | 40 |
GO:00308668 | Prostate | BPH | cortical actin cytoskeleton organization | 14/3107 | 40/18723 | 3.68e-03 | 1.85e-02 | 14 |
GO:00420634 | Prostate | BPH | gliogenesis | 68/3107 | 301/18723 | 4.06e-03 | 2.02e-02 | 68 |
GO:00714984 | Prostate | BPH | cellular response to fluid shear stress | 9/3107 | 21/18723 | 4.10e-03 | 2.03e-02 | 9 |
GO:00454452 | Prostate | BPH | myoblast differentiation | 24/3107 | 84/18723 | 4.13e-03 | 2.04e-02 | 24 |
GO:00343328 | Prostate | BPH | adherens junction organization | 16/3107 | 49/18723 | 4.35e-03 | 2.14e-02 | 16 |
GO:00712294 | Prostate | BPH | cellular response to acid chemical | 23/3107 | 80/18723 | 4.53e-03 | 2.19e-02 | 23 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEC | SNV | Missense_Mutation | | c.4341N>C | p.Glu1447Asp | p.E1447D | Q15149 | protein_coding | tolerated(1) | benign(0) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
PLEC | SNV | Missense_Mutation | | c.10135N>G | p.Pro3379Ala | p.P3379A | Q15149 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
PLEC | SNV | Missense_Mutation | | c.8535G>C | p.Glu2845Asp | p.E2845D | Q15149 | protein_coding | deleterious(0.02) | benign(0.026) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
PLEC | SNV | Missense_Mutation | rs368982802 | c.10961N>T | p.Thr3654Met | p.T3654M | Q15149 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEC | SNV | Missense_Mutation | | c.2672N>G | p.Ser891Cys | p.S891C | Q15149 | protein_coding | deleterious(0) | benign(0.139) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PLEC | SNV | Missense_Mutation | novel | c.8752N>C | p.Tyr2918His | p.Y2918H | Q15149 | protein_coding | deleterious(0.04) | possibly_damaging(0.853) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PLEC | SNV | Missense_Mutation | | c.1230G>T | p.Arg410Ser | p.R410S | Q15149 | protein_coding | tolerated(0.72) | benign(0.001) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEC | SNV | Missense_Mutation | rs782166303 | c.172C>T | p.Arg58Trp | p.R58W | Q15149 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEC | SNV | Missense_Mutation | novel | c.934N>G | p.Tyr312Asp | p.Y312D | Q15149 | protein_coding | deleterious(0) | possibly_damaging(0.615) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLEC | SNV | Missense_Mutation | novel | c.4297G>T | p.Val1433Leu | p.V1433L | Q15149 | protein_coding | tolerated(0.81) | benign(0) | TCGA-BH-A42T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |