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Gene: PCNA |
Gene summary for PCNA |
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Gene information | Species | Human | Gene symbol | PCNA | Gene ID | 5111 |
Gene name | proliferating cell nuclear antigen | |
Gene Alias | ATLD2 | |
Cytomap | 20p12.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P12004 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5111 | PCNA | GSM4909281 | Human | Breast | IDC | 1.92e-06 | 2.96e-01 | 0.21 |
5111 | PCNA | GSM4909282 | Human | Breast | IDC | 1.54e-24 | 5.82e-01 | -0.0288 |
5111 | PCNA | GSM4909285 | Human | Breast | IDC | 9.22e-23 | 5.19e-01 | 0.21 |
5111 | PCNA | GSM4909288 | Human | Breast | IDC | 1.92e-03 | 3.95e-01 | 0.0988 |
5111 | PCNA | GSM4909298 | Human | Breast | IDC | 5.22e-04 | 2.09e-01 | 0.1551 |
5111 | PCNA | GSM4909311 | Human | Breast | IDC | 6.26e-03 | -1.10e-01 | 0.1534 |
5111 | PCNA | GSM4909319 | Human | Breast | IDC | 2.74e-07 | -4.81e-02 | 0.1563 |
5111 | PCNA | brca2 | Human | Breast | Precancer | 4.18e-06 | 2.44e-01 | -0.024 |
5111 | PCNA | M2 | Human | Breast | IDC | 1.98e-09 | 6.53e-01 | 0.21 |
5111 | PCNA | NCCBC14 | Human | Breast | DCIS | 1.86e-03 | 1.63e-01 | 0.2021 |
5111 | PCNA | NCCBC5 | Human | Breast | DCIS | 4.22e-07 | 3.47e-01 | 0.2046 |
5111 | PCNA | P1 | Human | Breast | IDC | 1.40e-05 | 6.24e-03 | 0.1527 |
5111 | PCNA | P2 | Human | Breast | IDC | 1.56e-02 | 3.51e-01 | 0.21 |
5111 | PCNA | DCIS2 | Human | Breast | DCIS | 8.61e-24 | 2.79e-02 | 0.0085 |
5111 | PCNA | CA_HPV_3 | Human | Cervix | CC | 1.87e-04 | 2.66e-01 | 0.0414 |
5111 | PCNA | Tumor | Human | Cervix | CC | 1.91e-14 | 5.58e-01 | 0.1241 |
5111 | PCNA | sample3 | Human | Cervix | CC | 2.99e-20 | 5.95e-01 | 0.1387 |
5111 | PCNA | T3 | Human | Cervix | CC | 2.42e-25 | 6.42e-01 | 0.1389 |
5111 | PCNA | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.14e-08 | 3.94e-01 | -0.0811 |
5111 | PCNA | HTA11_78_2000001011 | Human | Colorectum | AD | 2.49e-06 | 3.68e-01 | -0.1088 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:010400417 | Oral cavity | LP | cellular response to environmental stimulus | 121/4623 | 331/18723 | 8.45e-07 | 2.20e-05 | 121 |
GO:1901654110 | Oral cavity | LP | response to ketone | 78/4623 | 194/18723 | 1.24e-06 | 3.03e-05 | 78 |
GO:000941112 | Oral cavity | LP | response to UV | 63/4623 | 149/18723 | 1.74e-06 | 4.05e-05 | 63 |
GO:0048545110 | Oral cavity | LP | response to steroid hormone | 122/4623 | 339/18723 | 1.91e-06 | 4.39e-05 | 122 |
GO:000188919 | Oral cavity | LP | liver development | 62/4623 | 147/18723 | 2.32e-06 | 5.14e-05 | 62 |
GO:000626011 | Oral cavity | LP | DNA replication | 97/4623 | 260/18723 | 3.67e-06 | 7.75e-05 | 97 |
GO:000931417 | Oral cavity | LP | response to radiation | 155/4623 | 456/18723 | 4.12e-06 | 8.49e-05 | 155 |
GO:0048732110 | Oral cavity | LP | gland development | 149/4623 | 436/18723 | 4.51e-06 | 9.17e-05 | 149 |
GO:006100819 | Oral cavity | LP | hepaticobiliary system development | 62/4623 | 150/18723 | 5.13e-06 | 1.03e-04 | 62 |
GO:007147815 | Oral cavity | LP | cellular response to radiation | 73/4623 | 186/18723 | 7.44e-06 | 1.41e-04 | 73 |
GO:007189715 | Oral cavity | LP | DNA biosynthetic process | 71/4623 | 180/18723 | 8.04e-06 | 1.52e-04 | 71 |
GO:005105213 | Oral cavity | LP | regulation of DNA metabolic process | 125/4623 | 359/18723 | 9.43e-06 | 1.75e-04 | 125 |
GO:005105415 | Oral cavity | LP | positive regulation of DNA metabolic process | 77/4623 | 201/18723 | 1.20e-05 | 2.15e-04 | 77 |
GO:003109916 | Oral cavity | LP | regeneration | 76/4623 | 198/18723 | 1.25e-05 | 2.24e-04 | 76 |
GO:200102018 | Oral cavity | LP | regulation of response to DNA damage stimulus | 82/4623 | 219/18723 | 1.71e-05 | 2.97e-04 | 82 |
GO:003464412 | Oral cavity | LP | cellular response to UV | 40/4623 | 90/18723 | 3.28e-05 | 5.02e-04 | 40 |
GO:0034614110 | Oral cavity | LP | cellular response to reactive oxygen species | 61/4623 | 155/18723 | 3.66e-05 | 5.43e-04 | 61 |
GO:200027818 | Oral cavity | LP | regulation of DNA biosynthetic process | 45/4623 | 106/18723 | 4.42e-05 | 6.30e-04 | 45 |
GO:004668617 | Oral cavity | LP | response to cadmium ion | 32/4623 | 68/18723 | 5.05e-05 | 7.07e-04 | 32 |
GO:0010038110 | Oral cavity | LP | response to metal ion | 124/4623 | 373/18723 | 1.09e-04 | 1.31e-03 | 124 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0453018 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0453019 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0453024 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0453034 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0453044 | Breast | DCIS | Tight junction | 37/846 | 169/8465 | 3.07e-06 | 4.20e-05 | 3.09e-05 | 37 |
hsa0453054 | Breast | DCIS | Tight junction | 37/846 | 169/8465 | 3.07e-06 | 4.20e-05 | 3.09e-05 | 37 |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa041106 | Cervix | CC | Cell cycle | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0411013 | Cervix | CC | Cell cycle | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa045302 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa045303 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa045304 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa05161 | Colorectum | MSS | Hepatitis B | 48/1875 | 162/8465 | 1.53e-02 | 4.93e-02 | 3.02e-02 | 48 |
hsa045305 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa051611 | Colorectum | MSS | Hepatitis B | 48/1875 | 162/8465 | 1.53e-02 | 4.93e-02 | 3.02e-02 | 48 |
hsa045306 | Colorectum | MSI-H | Tight junction | 31/797 | 169/8465 | 2.08e-04 | 2.80e-03 | 2.35e-03 | 31 |
hsa045307 | Colorectum | MSI-H | Tight junction | 31/797 | 169/8465 | 2.08e-04 | 2.80e-03 | 2.35e-03 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCNA | SNV | Missense_Mutation | novel | c.7N>C | p.Glu3Gln | p.E3Q | P12004 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
PCNA | SNV | Missense_Mutation | novel | c.199N>C | p.Ala67Pro | p.A67P | P12004 | protein_coding | tolerated(0.21) | benign(0.432) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
PCNA | SNV | Missense_Mutation | c.581N>T | p.Ala194Val | p.A194V | P12004 | protein_coding | tolerated(0.1) | benign(0.344) | TCGA-AA-3688-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PCNA | SNV | Missense_Mutation | c.256G>T | p.Asp86Tyr | p.D86Y | P12004 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PCNA | SNV | Missense_Mutation | c.208G>A | p.Val70Met | p.V70M | P12004 | protein_coding | tolerated(0.84) | benign(0.053) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCNA | SNV | Missense_Mutation | c.506N>G | p.Phe169Cys | p.F169C | P12004 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-3999-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unspecific | PD | ||
PCNA | SNV | Missense_Mutation | c.731T>G | p.Met244Arg | p.M244R | P12004 | protein_coding | tolerated(0.21) | possibly_damaging(0.881) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PCNA | SNV | Missense_Mutation | novel | c.385N>T | p.Pro129Ser | p.P129S | P12004 | protein_coding | deleterious(0) | possibly_damaging(0.541) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PCNA | SNV | Missense_Mutation | novel | c.536A>G | p.Asn179Ser | p.N179S | P12004 | protein_coding | tolerated(0.6) | benign(0.015) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCNA | SNV | Missense_Mutation | c.109C>A | p.Leu37Met | p.L37M | P12004 | protein_coding | deleterious(0.05) | probably_damaging(0.936) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5111 | PCNA | NA | ATX-101 | DEOXYCHOLIC ACID | ||
5111 | PCNA | NA | VIT-100 | |||
5111 | PCNA | NA | CAPSAICIN | CAPSAICIN | 9435579 | |
5111 | PCNA | NA | PENTOXIFYLLINE | PENTOXIFYLLINE | 10707869 | |
5111 | PCNA | NA | SUNSCREEN | 17021352 |
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