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Gene: NCK2 |
Gene summary for NCK2 |
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Gene information | Species | Human | Gene symbol | NCK2 | Gene ID | 8440 |
Gene name | NCK adaptor protein 2 | |
Gene Alias | GRB4 | |
Cytomap | 2q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A0S2Z4M6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8440 | NCK2 | CCI_1 | Human | Cervix | CC | 1.34e-04 | 6.41e-01 | 0.528 |
8440 | NCK2 | CCI_3 | Human | Cervix | CC | 5.98e-08 | 8.91e-01 | 0.516 |
8440 | NCK2 | C04 | Human | Oral cavity | OSCC | 6.53e-07 | 5.94e-01 | 0.2633 |
8440 | NCK2 | C21 | Human | Oral cavity | OSCC | 1.33e-05 | 4.28e-01 | 0.2678 |
8440 | NCK2 | C30 | Human | Oral cavity | OSCC | 1.48e-24 | 1.15e+00 | 0.3055 |
8440 | NCK2 | C38 | Human | Oral cavity | OSCC | 2.40e-05 | 8.24e-01 | 0.172 |
8440 | NCK2 | C43 | Human | Oral cavity | OSCC | 9.54e-10 | 2.48e-01 | 0.1704 |
8440 | NCK2 | C46 | Human | Oral cavity | OSCC | 1.93e-09 | 3.27e-01 | 0.1673 |
8440 | NCK2 | C51 | Human | Oral cavity | OSCC | 9.64e-07 | 6.24e-01 | 0.2674 |
8440 | NCK2 | C57 | Human | Oral cavity | OSCC | 1.41e-05 | 3.71e-01 | 0.1679 |
8440 | NCK2 | C08 | Human | Oral cavity | OSCC | 8.04e-11 | 2.14e-01 | 0.1919 |
8440 | NCK2 | LN38 | Human | Oral cavity | OSCC | 2.21e-02 | 7.23e-01 | 0.168 |
8440 | NCK2 | EOLP-1 | Human | Oral cavity | EOLP | 1.55e-02 | 1.59e-01 | -0.0202 |
8440 | NCK2 | NEOLP-3 | Human | Oral cavity | NEOLP | 6.99e-04 | 2.25e-01 | -0.0191 |
8440 | NCK2 | SYSMH1 | Human | Oral cavity | OSCC | 1.71e-12 | 3.15e-01 | 0.1127 |
8440 | NCK2 | SYSMH2 | Human | Oral cavity | OSCC | 2.11e-14 | 3.97e-01 | 0.2326 |
8440 | NCK2 | SYSMH3 | Human | Oral cavity | OSCC | 4.80e-17 | 4.65e-01 | 0.2442 |
8440 | NCK2 | SYSMH5 | Human | Oral cavity | OSCC | 1.58e-04 | 1.17e-01 | 0.0647 |
8440 | NCK2 | SYSMH6 | Human | Oral cavity | OSCC | 2.39e-07 | 2.47e-01 | 0.1275 |
8440 | NCK2 | P1_S1_AK | Human | Skin | AK | 8.08e-08 | 3.48e-01 | -0.3399 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:2001233113 | Thyroid | PTC | regulation of apoptotic signaling pathway | 197/5968 | 356/18723 | 2.58e-20 | 3.69e-18 | 197 |
GO:0097193113 | Thyroid | PTC | intrinsic apoptotic signaling pathway | 164/5968 | 288/18723 | 9.17e-19 | 1.09e-16 | 164 |
GO:0006413112 | Thyroid | PTC | translational initiation | 84/5968 | 118/18723 | 1.89e-18 | 2.09e-16 | 84 |
GO:1902903113 | Thyroid | PTC | regulation of supramolecular fiber organization | 202/5968 | 383/18723 | 1.16e-17 | 1.15e-15 | 202 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
GO:0007015112 | Thyroid | PTC | actin filament organization | 225/5968 | 442/18723 | 3.76e-17 | 3.44e-15 | 225 |
GO:0035966113 | Thyroid | PTC | response to topologically incorrect protein | 101/5968 | 159/18723 | 2.00e-16 | 1.66e-14 | 101 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
GO:0010563113 | Thyroid | PTC | negative regulation of phosphorus metabolic process | 219/5968 | 442/18723 | 4.47e-15 | 3.07e-13 | 219 |
GO:0045936113 | Thyroid | PTC | negative regulation of phosphate metabolic process | 218/5968 | 441/18723 | 7.08e-15 | 4.75e-13 | 218 |
GO:0006986113 | Thyroid | PTC | response to unfolded protein | 87/5968 | 137/18723 | 2.46e-14 | 1.57e-12 | 87 |
GO:0032956113 | Thyroid | PTC | regulation of actin cytoskeleton organization | 182/5968 | 358/18723 | 4.64e-14 | 2.79e-12 | 182 |
GO:2001242113 | Thyroid | PTC | regulation of intrinsic apoptotic signaling pathway | 99/5968 | 164/18723 | 4.74e-14 | 2.79e-12 | 99 |
GO:0034250113 | Thyroid | PTC | positive regulation of cellular amide metabolic process | 98/5968 | 162/18723 | 5.26e-14 | 3.04e-12 | 98 |
GO:0032970113 | Thyroid | PTC | regulation of actin filament-based process | 197/5968 | 397/18723 | 8.91e-14 | 4.89e-12 | 197 |
GO:0001933113 | Thyroid | PTC | negative regulation of protein phosphorylation | 173/5968 | 342/18723 | 3.46e-13 | 1.75e-11 | 173 |
GO:0051258113 | Thyroid | PTC | protein polymerization | 154/5968 | 297/18723 | 5.35e-13 | 2.66e-11 | 154 |
GO:0110053112 | Thyroid | PTC | regulation of actin filament organization | 146/5968 | 278/18723 | 5.87e-13 | 2.85e-11 | 146 |
GO:0045727113 | Thyroid | PTC | positive regulation of translation | 84/5968 | 136/18723 | 6.52e-13 | 3.08e-11 | 84 |
GO:0042326113 | Thyroid | PTC | negative regulation of phosphorylation | 189/5968 | 385/18723 | 1.00e-12 | 4.64e-11 | 189 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513020 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
hsa0401210 | Cervix | CC | ErbB signaling pathway | 28/1267 | 85/8465 | 2.40e-05 | 1.82e-04 | 1.08e-04 | 28 |
hsa043609 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa046604 | Cervix | CC | T cell receptor signaling pathway | 25/1267 | 104/8465 | 9.52e-03 | 2.94e-02 | 1.74e-02 | 25 |
hsa05130110 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
hsa0401213 | Cervix | CC | ErbB signaling pathway | 28/1267 | 85/8465 | 2.40e-05 | 1.82e-04 | 1.08e-04 | 28 |
hsa0436012 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa0466011 | Cervix | CC | T cell receptor signaling pathway | 25/1267 | 104/8465 | 9.52e-03 | 2.94e-02 | 1.74e-02 | 25 |
hsa0513030 | Oral cavity | OSCC | Pathogenic Escherichia coli infection | 129/3704 | 197/8465 | 4.32e-10 | 5.17e-09 | 2.63e-09 | 129 |
hsa046606 | Oral cavity | OSCC | T cell receptor signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa0401216 | Oral cavity | OSCC | ErbB signaling pathway | 55/3704 | 85/8465 | 7.46e-05 | 2.81e-04 | 1.43e-04 | 55 |
hsa0436014 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa05130114 | Oral cavity | OSCC | Pathogenic Escherichia coli infection | 129/3704 | 197/8465 | 4.32e-10 | 5.17e-09 | 2.63e-09 | 129 |
hsa0466012 | Oral cavity | OSCC | T cell receptor signaling pathway | 67/3704 | 104/8465 | 1.57e-05 | 6.75e-05 | 3.44e-05 | 67 |
hsa0401217 | Oral cavity | OSCC | ErbB signaling pathway | 55/3704 | 85/8465 | 7.46e-05 | 2.81e-04 | 1.43e-04 | 55 |
hsa0436015 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa0513045 | Oral cavity | EOLP | Pathogenic Escherichia coli infection | 54/1218 | 197/8465 | 1.10e-06 | 9.96e-06 | 5.87e-06 | 54 |
hsa0466021 | Oral cavity | EOLP | T cell receptor signaling pathway | 34/1218 | 104/8465 | 1.63e-06 | 1.39e-05 | 8.18e-06 | 34 |
hsa0401223 | Oral cavity | EOLP | ErbB signaling pathway | 27/1218 | 85/8465 | 3.39e-05 | 1.69e-04 | 9.94e-05 | 27 |
hsa0436023 | Oral cavity | EOLP | Axon guidance | 38/1218 | 182/8465 | 1.02e-02 | 2.80e-02 | 1.65e-02 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCK2 | SNV | Missense_Mutation | novel | c.122N>G | p.Val41Gly | p.V41G | O43639 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A1G6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
NCK2 | SNV | Missense_Mutation | novel | c.568N>G | p.Asn190Asp | p.N190D | O43639 | protein_coding | tolerated(0.25) | benign(0.062) | TCGA-A7-A6VY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
NCK2 | SNV | Missense_Mutation | novel | c.547C>T | p.Arg183Cys | p.R183C | O43639 | protein_coding | deleterious(0.04) | possibly_damaging(0.513) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NCK2 | SNV | Missense_Mutation | novel | c.60N>T | p.Glu20Asp | p.E20D | O43639 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
NCK2 | SNV | Missense_Mutation | rs370241867 | c.872N>T | p.Thr291Met | p.T291M | O43639 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NCK2 | SNV | Missense_Mutation | rs754330998 | c.548N>A | p.Arg183His | p.R183H | O43639 | protein_coding | tolerated(0.33) | benign(0.255) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
NCK2 | SNV | Missense_Mutation | c.1028N>A | p.Cys343Tyr | p.C343Y | O43639 | protein_coding | tolerated(0.06) | possibly_damaging(0.9) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
NCK2 | SNV | Missense_Mutation | rs766993432 | c.592C>T | p.His198Tyr | p.H198Y | O43639 | protein_coding | deleterious(0.02) | benign(0.209) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NCK2 | SNV | Missense_Mutation | novel | c.826T>C | p.Ser276Pro | p.S276P | O43639 | protein_coding | tolerated(0.28) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NCK2 | SNV | Missense_Mutation | rs780151498 | c.836G>A | p.Arg279His | p.R279H | O43639 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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