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Gene: JUNB |
Gene summary for JUNB |
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Gene information | Species | Human | Gene symbol | JUNB | Gene ID | 3726 |
Gene name | JunB proto-oncogene, AP-1 transcription factor subunit | |
Gene Alias | AP-1 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P17275 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3726 | JUNB | GSM4909280 | Human | Breast | Precancer | 1.23e-02 | 4.42e-01 | 0.0305 |
3726 | JUNB | GSM4909281 | Human | Breast | IDC | 4.15e-07 | -4.93e-01 | 0.21 |
3726 | JUNB | GSM4909282 | Human | Breast | IDC | 2.42e-57 | 7.46e-01 | -0.0288 |
3726 | JUNB | GSM4909285 | Human | Breast | IDC | 4.26e-07 | 3.14e-01 | 0.21 |
3726 | JUNB | GSM4909290 | Human | Breast | IDC | 2.71e-04 | -4.08e-01 | 0.2096 |
3726 | JUNB | GSM4909294 | Human | Breast | IDC | 1.09e-19 | -7.18e-01 | 0.2022 |
3726 | JUNB | GSM4909296 | Human | Breast | IDC | 1.54e-07 | -5.06e-01 | 0.1524 |
3726 | JUNB | GSM4909297 | Human | Breast | IDC | 1.57e-10 | 1.00e-01 | 0.1517 |
3726 | JUNB | GSM4909299 | Human | Breast | IDC | 4.89e-06 | 3.52e-01 | 0.035 |
3726 | JUNB | GSM4909300 | Human | Breast | IDC | 7.10e-05 | 4.29e-01 | 0.0334 |
3726 | JUNB | GSM4909304 | Human | Breast | IDC | 3.65e-09 | -5.44e-01 | 0.1636 |
3726 | JUNB | GSM4909305 | Human | Breast | IDC | 3.08e-11 | 4.28e-01 | 0.0436 |
3726 | JUNB | GSM4909306 | Human | Breast | IDC | 1.17e-10 | 3.49e-01 | 0.1564 |
3726 | JUNB | GSM4909308 | Human | Breast | IDC | 8.75e-25 | 5.47e-01 | 0.158 |
3726 | JUNB | GSM4909311 | Human | Breast | IDC | 6.18e-24 | -2.76e-01 | 0.1534 |
3726 | JUNB | GSM4909312 | Human | Breast | IDC | 9.91e-17 | 4.04e-01 | 0.1552 |
3726 | JUNB | GSM4909313 | Human | Breast | IDC | 2.93e-12 | 4.41e-01 | 0.0391 |
3726 | JUNB | GSM4909315 | Human | Breast | IDC | 7.28e-17 | -6.80e-01 | 0.21 |
3726 | JUNB | GSM4909316 | Human | Breast | IDC | 1.01e-08 | -7.66e-01 | 0.21 |
3726 | JUNB | GSM4909319 | Human | Breast | IDC | 6.89e-36 | 1.66e-01 | 0.1563 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
GO:000756517 | Thyroid | ATC | female pregnancy | 82/6293 | 193/18723 | 6.04e-03 | 2.42e-02 | 82 |
GO:006067413 | Thyroid | ATC | placenta blood vessel development | 17/6293 | 30/18723 | 7.88e-03 | 3.06e-02 | 17 |
GO:007124823 | Thyroid | ATC | cellular response to metal ion | 82/6293 | 197/18723 | 1.11e-02 | 3.99e-02 | 82 |
GO:00601358 | Thyroid | ATC | maternal process involved in female pregnancy | 30/6293 | 62/18723 | 1.12e-02 | 4.00e-02 | 30 |
GO:0002573110 | Thyroid | ATC | myeloid leukocyte differentiation | 86/6293 | 208/18723 | 1.15e-02 | 4.11e-02 | 86 |
GO:000157021 | Thyroid | ATC | vasculogenesis | 37/6293 | 80/18723 | 1.26e-02 | 4.42e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa046686 | Cervix | CC | TNF signaling pathway | 28/1267 | 114/8465 | 4.60e-03 | 1.62e-02 | 9.59e-03 | 28 |
hsa0466813 | Cervix | CC | TNF signaling pathway | 28/1267 | 114/8465 | 4.60e-03 | 1.62e-02 | 9.59e-03 | 28 |
hsa04935 | Colorectum | MSS | Growth hormone synthesis, secretion and action | 42/1875 | 120/8465 | 8.17e-04 | 5.16e-03 | 3.16e-03 | 42 |
hsa049351 | Colorectum | MSS | Growth hormone synthesis, secretion and action | 42/1875 | 120/8465 | 8.17e-04 | 5.16e-03 | 3.16e-03 | 42 |
hsa046687 | Endometrium | EEC | TNF signaling pathway | 27/1237 | 114/8465 | 6.47e-03 | 3.22e-02 | 2.40e-02 | 27 |
hsa0466814 | Endometrium | EEC | TNF signaling pathway | 27/1237 | 114/8465 | 6.47e-03 | 3.22e-02 | 2.40e-02 | 27 |
hsa0466810 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa0466817 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa046684 | Liver | HCC | TNF signaling pathway | 73/4020 | 114/8465 | 2.53e-04 | 1.19e-03 | 6.63e-04 | 73 |
hsa0466811 | Liver | HCC | TNF signaling pathway | 73/4020 | 114/8465 | 2.53e-04 | 1.19e-03 | 6.63e-04 | 73 |
hsa046682 | Liver | Cyst | TNF signaling pathway | 12/339 | 114/8465 | 1.96e-03 | 1.88e-02 | 1.56e-02 | 12 |
hsa046683 | Liver | Cyst | TNF signaling pathway | 12/339 | 114/8465 | 1.96e-03 | 1.88e-02 | 1.56e-02 | 12 |
hsa046685 | Lung | IAC | TNF signaling pathway | 25/1053 | 114/8465 | 3.01e-03 | 1.53e-02 | 1.02e-02 | 25 |
hsa04380 | Lung | IAC | Osteoclast differentiation | 27/1053 | 128/8465 | 3.74e-03 | 1.84e-02 | 1.22e-02 | 27 |
hsa049356 | Lung | IAC | Growth hormone synthesis, secretion and action | 24/1053 | 120/8465 | 1.18e-02 | 4.22e-02 | 2.80e-02 | 24 |
hsa0466812 | Lung | IAC | TNF signaling pathway | 25/1053 | 114/8465 | 3.01e-03 | 1.53e-02 | 1.02e-02 | 25 |
hsa043801 | Lung | IAC | Osteoclast differentiation | 27/1053 | 128/8465 | 3.74e-03 | 1.84e-02 | 1.22e-02 | 27 |
hsa0493511 | Lung | IAC | Growth hormone synthesis, secretion and action | 24/1053 | 120/8465 | 1.18e-02 | 4.22e-02 | 2.80e-02 | 24 |
hsa0493521 | Lung | AIS | Growth hormone synthesis, secretion and action | 23/961 | 120/8465 | 7.85e-03 | 3.58e-02 | 2.29e-02 | 23 |
hsa0493531 | Lung | AIS | Growth hormone synthesis, secretion and action | 23/961 | 120/8465 | 7.85e-03 | 3.58e-02 | 2.29e-02 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JUNB | SNV | Missense_Mutation | novel | c.1003N>A | p.Gly335Ser | p.G335S | P17275 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
JUNB | SNV | Missense_Mutation | rs781257277 | c.167G>C | p.Arg56Pro | p.R56P | P17275 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
JUNB | SNV | Missense_Mutation | c.879N>G | p.Ile293Met | p.I293M | P17275 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
JUNB | deletion | Frame_Shift_Del | c.340delN | p.Gly115ValfsTer35 | p.G115Vfs*35 | P17275 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
JUNB | deletion | Frame_Shift_Del | c.340delN | p.Gly115ValfsTer35 | p.G115Vfs*35 | P17275 | protein_coding | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
JUNB | deletion | Frame_Shift_Del | c.373delN | p.Gly126AlafsTer24 | p.G126Afs*24 | P17275 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
JUNB | deletion | Frame_Shift_Del | c.373delN | p.Gly126AlafsTer24 | p.G126Afs*24 | P17275 | protein_coding | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
JUNB | SNV | Missense_Mutation | novel | c.10N>G | p.Lys4Glu | p.K4E | P17275 | protein_coding | deleterious(0.02) | benign(0.269) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
JUNB | deletion | Frame_Shift_Del | c.340delN | p.Gly115ValfsTer35 | p.G115Vfs*35 | P17275 | protein_coding | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
JUNB | SNV | Missense_Mutation | c.394C>A | p.Gln132Lys | p.Q132K | P17275 | protein_coding | deleterious(0) | possibly_damaging(0.79) | TCGA-RC-A7SF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3726 | JUNB | TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR | UVB | 9607142 | ||
3726 | JUNB | TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR | INSULIN | INSULIN | 8264634 | |
3726 | JUNB | TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR | CYTOKINES | 9591138 | ||
3726 | JUNB | TRANSCRIPTION FACTOR, TRANSCRIPTION FACTOR BINDING, TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR | DEXAMETHASONE | DEXAMETHASONE | 9024781 |
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