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Gene: INE1 |
Gene summary for INE1 |
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Gene information | Species | Human | Gene symbol | INE1 | Gene ID | 8552 |
Gene name | inactivation escape 1 | |
Gene Alias | NCRNA00010 | |
Cytomap | Xp11.3 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8552 | INE1 | HCC1 | Human | Liver | HCC | 2.10e-06 | 1.87e+00 | 0.5336 |
8552 | INE1 | HCC2 | Human | Liver | HCC | 2.78e-04 | 7.61e-01 | 0.5341 |
8552 | INE1 | HCC5 | Human | Liver | HCC | 2.57e-02 | 4.34e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000268816 | Skin | SCCIS | regulation of leukocyte chemotaxis | 19/919 | 122/18723 | 7.60e-06 | 2.80e-04 | 19 |
GO:0052548112 | Skin | SCCIS | regulation of endopeptidase activity | 43/919 | 432/18723 | 8.92e-06 | 3.22e-04 | 43 |
GO:007167413 | Skin | SCCIS | mononuclear cell migration | 25/919 | 196/18723 | 1.19e-05 | 4.10e-04 | 25 |
GO:007167515 | Skin | SCCIS | regulation of mononuclear cell migration | 18/919 | 115/18723 | 1.22e-05 | 4.13e-04 | 18 |
GO:000269014 | Skin | SCCIS | positive regulation of leukocyte chemotaxis | 16/919 | 94/18723 | 1.25e-05 | 4.16e-04 | 16 |
GO:1903034110 | Skin | SCCIS | regulation of response to wounding | 22/919 | 167/18723 | 2.36e-05 | 6.65e-04 | 22 |
GO:0051346111 | Skin | SCCIS | negative regulation of hydrolase activity | 38/919 | 379/18723 | 2.49e-05 | 6.97e-04 | 38 |
GO:0097191112 | Skin | SCCIS | extrinsic apoptotic signaling pathway | 26/919 | 219/18723 | 2.87e-05 | 7.82e-04 | 26 |
GO:0010951110 | Skin | SCCIS | negative regulation of endopeptidase activity | 28/919 | 252/18723 | 4.82e-05 | 1.18e-03 | 28 |
GO:007167713 | Skin | SCCIS | positive regulation of mononuclear cell migration | 12/919 | 65/18723 | 6.61e-05 | 1.58e-03 | 12 |
GO:000759616 | Skin | SCCIS | blood coagulation | 25/919 | 217/18723 | 6.68e-05 | 1.59e-03 | 25 |
GO:0032496110 | Skin | SCCIS | response to lipopolysaccharide | 34/919 | 343/18723 | 8.22e-05 | 1.89e-03 | 34 |
GO:0010466110 | Skin | SCCIS | negative regulation of peptidase activity | 28/919 | 262/18723 | 9.55e-05 | 2.12e-03 | 28 |
GO:000759916 | Skin | SCCIS | hemostasis | 25/919 | 222/18723 | 9.68e-05 | 2.12e-03 | 25 |
GO:005081716 | Skin | SCCIS | coagulation | 25/919 | 222/18723 | 9.68e-05 | 2.12e-03 | 25 |
GO:0002237110 | Skin | SCCIS | response to molecule of bacterial origin | 35/919 | 363/18723 | 1.13e-04 | 2.41e-03 | 35 |
GO:009030316 | Skin | SCCIS | positive regulation of wound healing | 11/919 | 59/18723 | 1.21e-04 | 2.52e-03 | 11 |
GO:00025485 | Skin | SCCIS | monocyte chemotaxis | 12/919 | 70/18723 | 1.39e-04 | 2.87e-03 | 12 |
GO:0008625110 | Skin | SCCIS | extrinsic apoptotic signaling pathway via death domain receptors | 13/919 | 82/18723 | 1.69e-04 | 3.32e-03 | 13 |
GO:2001237112 | Skin | SCCIS | negative regulation of extrinsic apoptotic signaling pathway | 14/919 | 97/18723 | 2.67e-04 | 4.79e-03 | 14 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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