Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/HSPE1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/HSPE1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/HSPE1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/HSPE1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/HSPE1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HSPE1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/HSPE1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HSPE1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HSPE1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/HSPE1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HSPE1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HSPE1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004328131 | Stomach | CAG | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 19/552 | 209/18723 | 1.46e-05 | 5.69e-04 | 19 |
GO:001095231 | Stomach | CAG | positive regulation of peptidase activity | 17/552 | 197/18723 | 7.83e-05 | 2.10e-03 | 17 |
GO:001095031 | Stomach | CAG | positive regulation of endopeptidase activity | 15/552 | 179/18723 | 2.80e-04 | 5.41e-03 | 15 |
GO:20010563 | Stomach | CAG | positive regulation of cysteine-type endopeptidase activity | 13/552 | 148/18723 | 4.47e-04 | 7.68e-03 | 13 |
GO:00432803 | Stomach | CAG | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 11/552 | 129/18723 | 1.53e-03 | 1.86e-02 | 11 |
GO:000645741 | Stomach | WIM | protein folding | 28/426 | 212/18723 | 6.19e-14 | 8.17e-11 | 28 |
GO:00069864 | Stomach | WIM | response to unfolded protein | 22/426 | 137/18723 | 5.76e-13 | 5.71e-10 | 22 |
GO:00359664 | Stomach | WIM | response to topologically incorrect protein | 22/426 | 159/18723 | 1.25e-11 | 8.26e-09 | 22 |
GO:00510854 | Stomach | WIM | chaperone cofactor-dependent protein refolding | 11/426 | 34/18723 | 1.33e-10 | 5.89e-08 | 11 |
GO:00064584 | Stomach | WIM | 'de novo' protein folding | 12/426 | 43/18723 | 1.34e-10 | 5.89e-08 | 12 |
GO:00610774 | Stomach | WIM | chaperone-mediated protein folding | 14/426 | 67/18723 | 2.63e-10 | 1.04e-07 | 14 |
GO:00510844 | Stomach | WIM | 'de novo' posttranslational protein folding | 11/426 | 39/18723 | 7.03e-10 | 1.74e-07 | 11 |
GO:005254841 | Stomach | WIM | regulation of endopeptidase activity | 26/426 | 432/18723 | 7.15e-06 | 3.54e-04 | 26 |
GO:005254741 | Stomach | WIM | regulation of peptidase activity | 27/426 | 461/18723 | 7.84e-06 | 3.79e-04 | 27 |
GO:200011641 | Stomach | WIM | regulation of cysteine-type endopeptidase activity | 16/426 | 235/18723 | 1.02e-04 | 2.76e-03 | 16 |
GO:004328141 | Stomach | WIM | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 14/426 | 209/18723 | 3.21e-04 | 6.53e-03 | 14 |
GO:004586241 | Stomach | WIM | positive regulation of proteolysis | 20/426 | 372/18723 | 3.63e-04 | 7.19e-03 | 20 |
GO:001095241 | Stomach | WIM | positive regulation of peptidase activity | 12/426 | 197/18723 | 1.91e-03 | 2.38e-02 | 12 |
GO:00109504 | Stomach | WIM | positive regulation of endopeptidase activity | 11/426 | 179/18723 | 2.71e-03 | 3.07e-02 | 11 |
GO:00064575 | Stomach | SIM | protein folding | 39/708 | 212/18723 | 1.60e-16 | 1.08e-13 | 39 |