Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/CLASP2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CLASP2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CLASP2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CLASP2_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CLASP2_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CLASP2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003432912 | Lung | AIS | cell junction assembly | 84/1849 | 420/18723 | 2.16e-10 | 5.71e-08 | 84 |
GO:000195212 | Lung | AIS | regulation of cell-matrix adhesion | 38/1849 | 128/18723 | 2.93e-10 | 7.42e-08 | 38 |
GO:015011613 | Lung | AIS | regulation of cell-substrate junction organization | 26/1849 | 71/18723 | 1.30e-09 | 2.52e-07 | 26 |
GO:007265912 | Lung | AIS | protein localization to plasma membrane | 58/1849 | 284/18723 | 6.25e-08 | 7.14e-06 | 58 |
GO:005101713 | Lung | AIS | actin filament bundle assembly | 38/1849 | 157/18723 | 1.36e-07 | 1.44e-05 | 38 |
GO:199077812 | Lung | AIS | protein localization to cell periphery | 64/1849 | 333/18723 | 1.42e-07 | 1.48e-05 | 64 |
GO:006157213 | Lung | AIS | actin filament bundle organization | 38/1849 | 161/18723 | 2.71e-07 | 2.37e-05 | 38 |
GO:003103213 | Lung | AIS | actomyosin structure organization | 43/1849 | 196/18723 | 4.08e-07 | 3.25e-05 | 43 |
GO:003295613 | Lung | AIS | regulation of actin cytoskeleton organization | 63/1849 | 358/18723 | 4.06e-06 | 2.09e-04 | 63 |
GO:003297013 | Lung | AIS | regulation of actin filament-based process | 68/1849 | 397/18723 | 4.49e-06 | 2.27e-04 | 68 |
GO:190290313 | Lung | AIS | regulation of supramolecular fiber organization | 66/1849 | 383/18723 | 5.01e-06 | 2.45e-04 | 66 |
GO:004206013 | Lung | AIS | wound healing | 71/1849 | 422/18723 | 5.32e-06 | 2.52e-04 | 71 |
GO:001063913 | Lung | AIS | negative regulation of organelle organization | 61/1849 | 348/18723 | 6.53e-06 | 2.92e-04 | 61 |
GO:190188811 | Lung | AIS | regulation of cell junction assembly | 41/1849 | 204/18723 | 7.76e-06 | 3.35e-04 | 41 |
GO:003003813 | Lung | AIS | contractile actin filament bundle assembly | 26/1849 | 106/18723 | 9.56e-06 | 4.06e-04 | 26 |
GO:004314913 | Lung | AIS | stress fiber assembly | 26/1849 | 106/18723 | 9.56e-06 | 4.06e-04 | 26 |
GO:00322321 | Lung | AIS | negative regulation of actin filament bundle assembly | 13/1849 | 35/18723 | 1.49e-05 | 5.44e-04 | 13 |
GO:011005313 | Lung | AIS | regulation of actin filament organization | 50/1849 | 278/18723 | 2.13e-05 | 7.27e-04 | 50 |
GO:004477211 | Lung | AIS | mitotic cell cycle phase transition | 69/1849 | 424/18723 | 2.23e-05 | 7.42e-04 | 69 |
GO:003223113 | Lung | AIS | regulation of actin filament bundle assembly | 25/1849 | 105/18723 | 2.43e-05 | 8.01e-04 | 25 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLASP2 | SNV | Missense_Mutation | | c.1111N>A | p.Asp371Asn | p.D371N | | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
CLASP2 | SNV | Missense_Mutation | | c.293N>C | p.Ile98Thr | p.I98T | | protein_coding | tolerated(0.23) | benign(0.234) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CLASP2 | SNV | Missense_Mutation | | c.1355T>C | p.Val452Ala | p.V452A | | protein_coding | tolerated(0.06) | probably_damaging(0.954) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLASP2 | SNV | Missense_Mutation | rs554149266 | c.1343N>A | p.Arg448Gln | p.R448Q | | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLASP2 | SNV | Missense_Mutation | novel | c.3842G>T | p.Gly1281Val | p.G1281V | | protein_coding | deleterious(0.03) | possibly_damaging(0.531) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
CLASP2 | SNV | Missense_Mutation | novel | c.179N>A | p.Gly60Glu | p.G60E | | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CLASP2 | SNV | Missense_Mutation | | c.2793N>A | p.Met931Ile | p.M931I | | protein_coding | deleterious(0.01) | benign(0.233) | TCGA-BH-A18T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CLASP2 | SNV | Missense_Mutation | | c.2897C>G | p.Ser966Cys | p.S966C | | protein_coding | deleterious(0.03) | possibly_damaging(0.54) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
CLASP2 | SNV | Missense_Mutation | novel | c.2311N>G | p.Leu771Val | p.L771V | | protein_coding | tolerated(0.17) | possibly_damaging(0.875) | TCGA-E2-A14V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
CLASP2 | insertion | Nonsense_Mutation | novel | c.2873_2874insCTAGGGATGAGGCCTACATGACCATGGTG | p.Met958IlefsTer2 | p.M958Ifs*2 | | protein_coding | | | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |