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Gene: TUT4 |
Gene summary for TUT4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TUT4 | Gene ID | 23318 |
Gene name | terminal uridylyl transferase 4 | |
Gene Alias | PAPD3 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A0C4DFM7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23318 | TUT4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.96e-10 | -3.80e-01 | 0.0155 |
23318 | TUT4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.17e-03 | -4.02e-01 | -0.1808 |
23318 | TUT4 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.92e-03 | -4.73e-01 | -0.1526 |
23318 | TUT4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.17e-03 | -3.02e-01 | -0.1464 |
23318 | TUT4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.81e-03 | -1.29e-01 | 0.0588 |
23318 | TUT4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.51e-40 | -6.77e-01 | 0.294 |
23318 | TUT4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.78e-14 | -6.77e-01 | 0.281 |
23318 | TUT4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.28e-38 | -6.77e-01 | 0.3859 |
23318 | TUT4 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.15e-11 | -6.77e-01 | 0.2585 |
23318 | TUT4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.22e-41 | -6.77e-01 | 0.3005 |
23318 | TUT4 | A015-C-203 | Human | Colorectum | FAP | 1.31e-23 | -2.17e-01 | -0.1294 |
23318 | TUT4 | A015-C-204 | Human | Colorectum | FAP | 8.35e-04 | -2.42e-01 | -0.0228 |
23318 | TUT4 | A002-C-201 | Human | Colorectum | FAP | 3.62e-10 | -2.48e-01 | 0.0324 |
23318 | TUT4 | A002-C-203 | Human | Colorectum | FAP | 2.48e-03 | -1.33e-01 | 0.2786 |
23318 | TUT4 | A001-C-108 | Human | Colorectum | FAP | 2.55e-15 | -1.48e-02 | -0.0272 |
23318 | TUT4 | A002-C-205 | Human | Colorectum | FAP | 3.98e-15 | -1.55e-01 | -0.1236 |
23318 | TUT4 | A015-C-006 | Human | Colorectum | FAP | 8.06e-10 | -1.47e-01 | -0.0994 |
23318 | TUT4 | A015-C-106 | Human | Colorectum | FAP | 2.61e-06 | 3.24e-03 | -0.0511 |
23318 | TUT4 | A002-C-114 | Human | Colorectum | FAP | 1.07e-11 | -9.15e-02 | -0.1561 |
23318 | TUT4 | A015-C-104 | Human | Colorectum | FAP | 3.41e-26 | 3.12e-02 | -0.1899 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003424915 | Skin | cSCC | negative regulation of cellular amide metabolic process | 104/4864 | 273/18723 | 6.44e-06 | 9.00e-05 | 104 |
GO:009872715 | Skin | cSCC | maintenance of cell number | 58/4864 | 134/18723 | 9.83e-06 | 1.29e-04 | 58 |
GO:001714814 | Skin | cSCC | negative regulation of translation | 93/4864 | 245/18723 | 2.28e-05 | 2.63e-04 | 93 |
GO:000028818 | Skin | cSCC | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 29/4864 | 56/18723 | 3.25e-05 | 3.56e-04 | 29 |
GO:003105023 | Skin | cSCC | dsRNA processing | 27/4864 | 54/18723 | 1.32e-04 | 1.19e-03 | 27 |
GO:007091823 | Skin | cSCC | production of small RNA involved in gene silencing by RNA | 27/4864 | 54/18723 | 1.32e-04 | 1.19e-03 | 27 |
GO:003519623 | Skin | cSCC | production of miRNAs involved in gene silencing by miRNA | 26/4864 | 52/18723 | 1.74e-04 | 1.49e-03 | 26 |
GO:00346614 | Skin | cSCC | ncRNA catabolic process | 20/4864 | 43/18723 | 2.91e-03 | 1.62e-02 | 20 |
GO:000028917 | Skin | cSCC | nuclear-transcribed mRNA poly(A) tail shortening | 14/4864 | 29/18723 | 8.08e-03 | 3.74e-02 | 14 |
GO:001058622 | Skin | cSCC | miRNA metabolic process | 13/4864 | 27/18723 | 1.09e-02 | 4.74e-02 | 13 |
GO:0009896113 | Thyroid | PTC | positive regulation of catabolic process | 278/5968 | 492/18723 | 3.35e-30 | 2.64e-27 | 278 |
GO:0031331113 | Thyroid | PTC | positive regulation of cellular catabolic process | 249/5968 | 427/18723 | 5.28e-30 | 3.58e-27 | 249 |
GO:1903311112 | Thyroid | PTC | regulation of mRNA metabolic process | 181/5968 | 288/18723 | 1.60e-27 | 5.94e-25 | 181 |
GO:003447018 | Thyroid | PTC | ncRNA processing | 215/5968 | 395/18723 | 7.14e-21 | 1.22e-18 | 215 |
GO:0006401112 | Thyroid | PTC | RNA catabolic process | 163/5968 | 278/18723 | 2.13e-20 | 3.27e-18 | 163 |
GO:0006402112 | Thyroid | PTC | mRNA catabolic process | 139/5968 | 232/18723 | 9.59e-19 | 1.12e-16 | 139 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
GO:0034655112 | Thyroid | PTC | nucleobase-containing compound catabolic process | 211/5968 | 407/18723 | 2.72e-17 | 2.52e-15 | 211 |
GO:0000956111 | Thyroid | PTC | nuclear-transcribed mRNA catabolic process | 78/5968 | 112/18723 | 2.37e-16 | 1.94e-14 | 78 |
GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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