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Gene: TNFRSF1A |
Gene summary for TNFRSF1A |
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Gene information | Species | Human | Gene symbol | TNFRSF1A | Gene ID | 7132 |
Gene name | TNF receptor superfamily member 1A | |
Gene Alias | CD120a | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0001885 | UniProtAcc | P19438 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7132 | TNFRSF1A | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.09e-05 | 4.40e-01 | -0.1808 |
7132 | TNFRSF1A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.09e-05 | 3.28e-01 | -0.1954 |
7132 | TNFRSF1A | HTA11_411_2000001011 | Human | Colorectum | SER | 4.81e-02 | 8.89e-01 | -0.2602 |
7132 | TNFRSF1A | HTA11_696_2000001011 | Human | Colorectum | AD | 2.23e-05 | 3.82e-01 | -0.1464 |
7132 | TNFRSF1A | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.65e-07 | 4.56e-01 | -0.059 |
7132 | TNFRSF1A | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.38e-03 | 1.37e-01 | 0.0674 |
7132 | TNFRSF1A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.03e-04 | 2.34e-01 | 0.3859 |
7132 | TNFRSF1A | A015-C-203 | Human | Colorectum | FAP | 8.20e-03 | -1.17e-01 | -0.1294 |
7132 | TNFRSF1A | A002-C-205 | Human | Colorectum | FAP | 4.05e-02 | -1.45e-01 | -0.1236 |
7132 | TNFRSF1A | A002-C-016 | Human | Colorectum | FAP | 4.45e-04 | -1.44e-01 | 0.0521 |
7132 | TNFRSF1A | A002-C-116 | Human | Colorectum | FAP | 5.45e-03 | -1.57e-01 | -0.0452 |
7132 | TNFRSF1A | F034 | Human | Colorectum | FAP | 3.81e-02 | -1.41e-01 | -0.0665 |
7132 | TNFRSF1A | CRC-3-11773 | Human | Colorectum | CRC | 2.19e-02 | -8.51e-02 | 0.2564 |
7132 | TNFRSF1A | LZE2T | Human | Esophagus | ESCC | 4.29e-03 | 3.71e-02 | 0.082 |
7132 | TNFRSF1A | LZE3D | Human | Esophagus | HGIN | 5.58e-03 | 4.70e-01 | 0.0668 |
7132 | TNFRSF1A | LZE4T | Human | Esophagus | ESCC | 5.99e-16 | 2.96e-01 | 0.0811 |
7132 | TNFRSF1A | LZE5T | Human | Esophagus | ESCC | 1.41e-02 | 2.52e-01 | 0.0514 |
7132 | TNFRSF1A | LZE8T | Human | Esophagus | ESCC | 1.37e-05 | 3.36e-01 | 0.067 |
7132 | TNFRSF1A | LZE20T | Human | Esophagus | ESCC | 7.22e-09 | 2.15e-01 | 0.0662 |
7132 | TNFRSF1A | LZE22D1 | Human | Esophagus | HGIN | 3.91e-05 | 9.52e-02 | 0.0595 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00346124 | Stomach | WIM | response to tumor necrosis factor | 18/426 | 253/18723 | 2.12e-05 | 8.33e-04 | 18 |
GO:00192211 | Stomach | WIM | cytokine-mediated signaling pathway | 26/426 | 472/18723 | 3.31e-05 | 1.16e-03 | 26 |
GO:00971914 | Stomach | WIM | extrinsic apoptotic signaling pathway | 16/426 | 219/18723 | 4.40e-05 | 1.38e-03 | 16 |
GO:00332094 | Stomach | WIM | tumor necrosis factor-mediated signaling pathway | 10/426 | 99/18723 | 8.58e-05 | 2.40e-03 | 10 |
GO:00096123 | Stomach | WIM | response to mechanical stimulus | 14/426 | 216/18723 | 4.48e-04 | 8.34e-03 | 14 |
GO:000663131 | Stomach | WIM | fatty acid metabolic process | 20/426 | 390/18723 | 6.59e-04 | 1.07e-02 | 20 |
GO:000315841 | Stomach | WIM | endothelium development | 10/426 | 136/18723 | 1.11e-03 | 1.63e-02 | 10 |
GO:00321031 | Stomach | WIM | positive regulation of response to external stimulus | 20/426 | 427/18723 | 1.96e-03 | 2.41e-02 | 20 |
GO:000188531 | Stomach | WIM | endothelial cell development | 6/426 | 64/18723 | 3.30e-03 | 3.41e-02 | 6 |
GO:006102831 | Stomach | WIM | establishment of endothelial barrier | 5/426 | 46/18723 | 3.79e-03 | 3.71e-02 | 5 |
GO:00712143 | Stomach | WIM | cellular response to abiotic stimulus | 16/426 | 331/18723 | 3.96e-03 | 3.84e-02 | 16 |
GO:01040043 | Stomach | WIM | cellular response to environmental stimulus | 16/426 | 331/18723 | 3.96e-03 | 3.84e-02 | 16 |
GO:004544631 | Stomach | WIM | endothelial cell differentiation | 8/426 | 118/18723 | 5.59e-03 | 4.78e-02 | 8 |
GO:0097193113 | Thyroid | PTC | intrinsic apoptotic signaling pathway | 164/5968 | 288/18723 | 9.17e-19 | 1.09e-16 | 164 |
GO:0072659112 | Thyroid | PTC | protein localization to plasma membrane | 153/5968 | 284/18723 | 9.90e-15 | 6.50e-13 | 153 |
GO:1990778111 | Thyroid | PTC | protein localization to cell periphery | 172/5968 | 333/18723 | 3.71e-14 | 2.30e-12 | 172 |
GO:0097191113 | Thyroid | PTC | extrinsic apoptotic signaling pathway | 117/5968 | 219/18723 | 2.73e-11 | 1.03e-09 | 117 |
GO:0071496113 | Thyroid | PTC | cellular response to external stimulus | 158/5968 | 320/18723 | 4.12e-11 | 1.47e-09 | 158 |
GO:0071214111 | Thyroid | PTC | cellular response to abiotic stimulus | 158/5968 | 331/18723 | 9.90e-10 | 2.89e-08 | 158 |
GO:0104004111 | Thyroid | PTC | cellular response to environmental stimulus | 158/5968 | 331/18723 | 9.90e-10 | 2.89e-08 | 158 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa04932 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa05132 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa05417 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa05166 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa049321 | Colorectum | AD | Non-alcoholic fatty liver disease | 90/2092 | 155/8465 | 4.83e-19 | 1.80e-17 | 1.15e-17 | 90 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa051711 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa051321 | Colorectum | AD | Salmonella infection | 102/2092 | 249/8465 | 7.65e-09 | 1.28e-07 | 8.17e-08 | 102 |
hsa054171 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Breast | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Breast | DCIS |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Breast | Healthy |
LTA | TNFRSF1A | LTA_TNFRSF1A | LT | Cervix | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Cervix | CC |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Cervix | Healthy |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Cervix | Precancer |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Endometrium | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Endometrium | AEH |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Endometrium | EEC |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Endometrium | Healthy |
LTA | TNFRSF1A | LTA_TNFRSF1A | LT | Esophagus | ESCC |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | GC | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | HNSCC | ADJ |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | HNSCC | OSCC |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | HNSCC | Precancer |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Liver | Healthy |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Liver | Precancer |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Lung | AAH |
TNF | TNFRSF1A | TNF_TNFRSF1A | TNF | Lung | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF1A | SNV | Missense_Mutation | rs199961053 | c.167N>T | p.Ser56Leu | p.S56L | P19438 | protein_coding | deleterious(0) | possibly_damaging(0.591) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF1A | SNV | Missense_Mutation | novel | c.829N>G | p.Pro277Ala | p.P277A | P19438 | protein_coding | tolerated(0.24) | benign(0) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF1A | SNV | Missense_Mutation | rs104895245 | c.265N>C | p.Phe89Leu | p.F89L | P19438 | protein_coding | deleterious(0.01) | possibly_damaging(0.898) | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TNFRSF1A | SNV | Missense_Mutation | c.74C>T | p.Ser25Leu | p.S25L | P19438 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TNFRSF1A | SNV | Missense_Mutation | novel | c.977N>T | p.Ala326Val | p.A326V | P19438 | protein_coding | tolerated(0.5) | benign(0.028) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNFRSF1A | SNV | Missense_Mutation | c.364N>T | p.Asp122Tyr | p.D122Y | P19438 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TNFRSF1A | SNV | Missense_Mutation | rs201794033 | c.928N>T | p.Pro310Ser | p.P310S | P19438 | protein_coding | tolerated(0.13) | possibly_damaging(0.902) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TNFRSF1A | SNV | Missense_Mutation | rs768168665 | c.1267N>T | p.Arg423Cys | p.R423C | P19438 | protein_coding | tolerated(0.15) | benign(0.153) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TNFRSF1A | SNV | Missense_Mutation | c.47N>C | p.Leu16Pro | p.L16P | P19438 | protein_coding | tolerated(0.14) | benign(0.026) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TNFRSF1A | SNV | Missense_Mutation | rs199961053 | c.167N>T | p.Ser56Leu | p.S56L | P19438 | protein_coding | deleterious(0) | possibly_damaging(0.591) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | UVB | 9754576 | ||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | CYCLOPHOSPHAMIDE | CYCLOPHOSPHAMIDE | 9894568 | |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | infliximab | INFLIXIMAB | 22480748 | |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | Tumor necrosis factor alpha (TNF-alpha) inhibitors | 22480748,24776844,25311255 | ||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | 178101767 | |||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | 178101757 | |||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | adalimumab | ADALIMUMAB | 22480748 | |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | 178101766 | |||
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | etanercept | ETANERCEPT | 22480748 | |
7132 | TNFRSF1A | CELL SURFACE, DRUGGABLE GENOME | CYT-6091 |
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