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Gene: STK39 |
Gene summary for STK39 |
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Gene information | Species | Human | Gene symbol | STK39 | Gene ID | 27347 |
Gene name | serine/threonine kinase 39 | |
Gene Alias | DCHT | |
Cytomap | 2q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9UEW8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27347 | STK39 | CCI_1 | Human | Cervix | CC | 1.80e-18 | 1.12e+00 | 0.528 |
27347 | STK39 | CCI_2 | Human | Cervix | CC | 6.28e-12 | 1.01e+00 | 0.5249 |
27347 | STK39 | CCI_3 | Human | Cervix | CC | 6.22e-07 | 5.63e-01 | 0.516 |
27347 | STK39 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.32e-16 | -5.59e-01 | 0.0155 |
27347 | STK39 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.84e-06 | -9.30e-01 | 0.0216 |
27347 | STK39 | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.83e-05 | -7.35e-01 | -0.2196 |
27347 | STK39 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.18e-16 | -8.90e-01 | -0.1207 |
27347 | STK39 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.63e-03 | -3.21e-01 | -0.1464 |
27347 | STK39 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.58e-11 | -4.97e-01 | -0.1001 |
27347 | STK39 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.47e-05 | -5.80e-01 | -0.1706 |
27347 | STK39 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.03e-08 | -7.95e-01 | -0.2061 |
27347 | STK39 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.74e-04 | -7.15e-01 | -0.1462 |
27347 | STK39 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.88e-02 | -5.99e-01 | -0.00410000000000005 |
27347 | STK39 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.63e-13 | -6.97e-01 | 0.096 |
27347 | STK39 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.26e-08 | -6.93e-01 | 0.0446 |
27347 | STK39 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.45e-07 | -7.89e-01 | 0.0451 |
27347 | STK39 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.87e-04 | -5.06e-01 | 0.0338 |
27347 | STK39 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.04e-11 | -5.03e-01 | 0.0674 |
27347 | STK39 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.69e-08 | -5.79e-01 | 0.0112 |
27347 | STK39 | HTA11_11156_2000001011 | Human | Colorectum | AD | 3.54e-02 | -9.18e-01 | 0.0397 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004677715 | Skin | cSCC | protein autophosphorylation | 84/4864 | 227/18723 | 1.53e-04 | 1.35e-03 | 84 |
GO:003287225 | Skin | cSCC | regulation of stress-activated MAPK cascade | 72/4864 | 192/18723 | 2.76e-04 | 2.22e-03 | 72 |
GO:000697021 | Skin | cSCC | response to osmotic stress | 35/4864 | 84/18723 | 1.23e-03 | 7.97e-03 | 35 |
GO:001820923 | Skin | cSCC | peptidyl-serine modification | 108/4864 | 338/18723 | 7.73e-03 | 3.60e-02 | 108 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK39 | SNV | Missense_Mutation | c.1466N>A | p.Ala489Asp | p.A489D | Q9UEW8 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AC-A2FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
STK39 | insertion | Nonsense_Mutation | novel | c.210_211insTAGAGCTTGGCTCTCTGGTTTGTGATCAACCTCA | p.Ser71Ter | p.S71* | Q9UEW8 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
STK39 | insertion | Nonsense_Mutation | novel | c.1193_1194insCTGGTCATCTTTTGATTAAGAGATCGTATTTGATTT | p.Ala398_Ala399insTrpSerSerPheAspTerGluIleValPheAspLeu | p.A398_A399insWSSFD*EIVFDL | Q9UEW8 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
STK39 | deletion | Frame_Shift_Del | novel | c.1269delC | p.Glu424AsnfsTer29 | p.E424Nfs*29 | Q9UEW8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
STK39 | insertion | Frame_Shift_Ins | novel | c.973_974insTCCTTCCAAAA | p.Arg325IlefsTer12 | p.R325Ifs*12 | Q9UEW8 | protein_coding | TCGA-E2-A15P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
STK39 | SNV | Missense_Mutation | c.361N>T | p.Val121Leu | p.V121L | Q9UEW8 | protein_coding | tolerated(0.07) | possibly_damaging(0.546) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
STK39 | SNV | Missense_Mutation | novel | c.1582T>G | p.Ser528Ala | p.S528A | Q9UEW8 | protein_coding | tolerated(0.14) | benign(0.045) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
STK39 | SNV | Missense_Mutation | novel | c.564N>C | p.Gln188His | p.Q188H | Q9UEW8 | protein_coding | tolerated(0.28) | possibly_damaging(0.859) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
STK39 | SNV | Missense_Mutation | novel | c.562N>G | p.Gln188Glu | p.Q188E | Q9UEW8 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-ZJ-AAXD-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
STK39 | SNV | Missense_Mutation | c.442G>A | p.Asp148Asn | p.D148N | Q9UEW8 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
27347 | STK39 | KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | losartan | LOSARTAN | 21993215 |
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