Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: SNX1

Gene summary for SNX1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SNX1

Gene ID

6642

Gene namesorting nexin 1
Gene AliasHsT17379
Cytomap15q22.31
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q13596


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6642SNX1LZE2THumanEsophagusESCC4.47e-024.23e-010.082
6642SNX1LZE4THumanEsophagusESCC8.41e-144.15e-010.0811
6642SNX1LZE7THumanEsophagusESCC3.76e-096.14e-010.0667
6642SNX1LZE8THumanEsophagusESCC5.92e-092.21e-010.067
6642SNX1LZE20THumanEsophagusESCC3.91e-051.67e-010.0662
6642SNX1LZE24THumanEsophagusESCC4.38e-223.92e-010.0596
6642SNX1LZE21THumanEsophagusESCC1.90e-052.02e-010.0655
6642SNX1LZE6THumanEsophagusESCC9.07e-052.80e-010.0845
6642SNX1P1T-EHumanEsophagusESCC1.25e-086.16e-010.0875
6642SNX1P2T-EHumanEsophagusESCC5.33e-317.67e-010.1177
6642SNX1P4T-EHumanEsophagusESCC2.54e-298.41e-010.1323
6642SNX1P5T-EHumanEsophagusESCC5.68e-203.36e-010.1327
6642SNX1P8T-EHumanEsophagusESCC3.60e-408.54e-010.0889
6642SNX1P9T-EHumanEsophagusESCC7.52e-123.67e-010.1131
6642SNX1P10T-EHumanEsophagusESCC6.44e-356.55e-010.116
6642SNX1P11T-EHumanEsophagusESCC6.28e-106.03e-010.1426
6642SNX1P12T-EHumanEsophagusESCC9.19e-408.10e-010.1122
6642SNX1P15T-EHumanEsophagusESCC5.68e-521.11e+000.1149
6642SNX1P16T-EHumanEsophagusESCC1.09e-742.24e+000.1153
6642SNX1P17T-EHumanEsophagusESCC9.76e-074.25e-010.1278
Page: 1 2 3 4 5 6 7 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000165517ThyroidPTCurogenital system development149/5968338/187231.41e-062.01e-05149
GO:007200114ThyroidPTCrenal system development135/5968302/187231.76e-062.43e-05135
GO:0006898110ThyroidPTCreceptor-mediated endocytosis112/5968244/187232.87e-063.74e-05112
GO:00032794ThyroidPTCcardiac septum development54/5968103/187231.17e-051.29e-0454
GO:000091019ThyroidPTCcytokinesis82/5968173/187231.37e-051.47e-0482
GO:004308718ThyroidPTCregulation of GTPase activity148/5968348/187231.63e-051.71e-04148
GO:00421479ThyroidPTCretrograde transport, endosome to Golgi48/596891/187232.86e-052.78e-0448
GO:00325068ThyroidPTCcytokinetic process25/596839/187233.50e-053.30e-0425
GO:004311219ThyroidPTCreceptor metabolic process77/5968166/187236.21e-055.47e-0477
GO:00616408ThyroidPTCcytoskeleton-dependent cytokinesis50/5968100/187231.20e-049.59e-0450
GO:00032055ThyroidPTCcardiac chamber development72/5968161/187234.13e-042.77e-0372
GO:009758119ThyroidPTClamellipodium organization44/596890/187235.59e-043.56e-0344
GO:004354714ThyroidPTCpositive regulation of GTPase activity103/5968255/187232.38e-031.25e-02103
GO:00608402ThyroidPTCartery development43/5968100/187231.25e-024.88e-0243
GO:0009896210ThyroidATCpositive regulation of catabolic process290/6293492/187232.15e-311.94e-28290
GO:004217635ThyroidATCregulation of protein catabolic process239/6293391/187232.63e-291.85e-26239
GO:0048193111ThyroidATCGolgi vesicle transport189/6293296/187239.58e-275.05e-24189
GO:002241124ThyroidATCcellular component disassembly248/6293443/187231.34e-223.69e-20248
GO:0045732210ThyroidATCpositive regulation of protein catabolic process148/6293231/187231.93e-214.36e-19148
GO:001623623ThyroidATCmacroautophagy169/6293291/187236.56e-187.69e-16169
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04144210EsophagusESCCEndocytosis186/4205251/84659.74e-164.66e-142.39e-14186
hsa0414437EsophagusESCCEndocytosis186/4205251/84659.74e-164.66e-142.39e-14186
hsa0414412LiverCirrhoticEndocytosis119/2530251/84652.33e-094.56e-082.81e-08119
hsa0414413LiverCirrhoticEndocytosis119/2530251/84652.33e-094.56e-082.81e-08119
hsa0414422LiverHCCEndocytosis178/4020251/84652.03e-145.22e-132.91e-13178
hsa0414432LiverHCCEndocytosis178/4020251/84652.03e-145.22e-132.91e-13178
hsa0414427Oral cavityOSCCEndocytosis174/3704251/84659.42e-174.51e-152.29e-15174
hsa04144112Oral cavityOSCCEndocytosis174/3704251/84659.42e-174.51e-152.29e-15174
hsa0414428Oral cavityLPEndocytosis121/2418251/84651.89e-113.70e-102.38e-10121
hsa0414436Oral cavityLPEndocytosis121/2418251/84651.89e-113.70e-102.38e-10121
hsa0414425ProstateBPHEndocytosis89/1718251/84651.06e-081.29e-077.99e-0889
hsa04144111ProstateBPHEndocytosis89/1718251/84651.06e-081.29e-077.99e-0889
hsa0414426ProstateTumorEndocytosis92/1791251/84657.83e-091.04e-076.43e-0892
hsa0414435ProstateTumorEndocytosis92/1791251/84657.83e-091.04e-076.43e-0892
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SNX1SNVMissense_Mutationnovelc.38N>Cp.Arg13Thrp.R13TQ13596protein_codingdeleterious_low_confidence(0)possibly_damaging(0.886)TCGA-A2-A0YK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
SNX1SNVMissense_Mutationc.76G>Ap.Glu26Lysp.E26KQ13596protein_codingtolerated_low_confidence(0.25)benign(0.221)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
SNX1SNVMissense_Mutationrs780100137c.1424N>Ap.Arg475Glnp.R475QQ13596protein_codingdeleterious(0.04)probably_damaging(0.939)TCGA-BH-A0BT-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
SNX1insertionNonsense_Mutationnovelc.1435_1436insGGCCTTCCTGAGGCCTAGTCCCCCTGTTCTTTTTCp.Ile479ArgfsTer4p.I479Rfs*4Q13596protein_codingTCGA-A8-A06P-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificSD
SNX1insertionIn_Frame_Insnovelc.478_479insGTAAACp.Asn160delinsSerLysHisp.N160delinsSKHQ13596protein_codingTCGA-AC-A3QQ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SNX1SNVMissense_Mutationrs754631936c.1300N>Ap.Glu434Lysp.E434KQ13596protein_codingtolerated(0.6)probably_damaging(0.973)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SNX1SNVMissense_Mutationc.1306C>Tp.Arg436Trpp.R436WQ13596protein_codingdeleterious(0)probably_damaging(0.969)TCGA-C5-A2M2-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SNX1SNVMissense_Mutationc.262C>Gp.Leu88Valp.L88VQ13596protein_codingdeleterious(0.01)possibly_damaging(0.668)TCGA-EK-A2RJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SNX1SNVMissense_Mutationc.76N>Cp.Glu26Glnp.E26QQ13596protein_codingtolerated_low_confidence(0.19)possibly_damaging(0.51)TCGA-IR-A3LK-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
SNX1SNVMissense_Mutationnovelc.1291C>Tp.Arg431Trpp.R431WQ13596protein_codingdeleterious(0)probably_damaging(0.999)TCGA-MA-AA42-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
Page: 1 2 3 4 5 6 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1