Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MAP4

Gene summary for MAP4

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MAP4

Gene ID

4134

Gene namemicrotubule associated protein 4
Gene AliasMAP4
Cytomap3p21.31
Gene Typeprotein-coding
GO ID

GO:0000226

UniProtAcc

P27816


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4134MAP4CA_HPV_1HumanCervixCC1.82e-035.82e-020.0264
4134MAP4CCI_2HumanCervixCC5.20e-058.20e-010.5249
4134MAP4CCI_3HumanCervixCC9.96e-111.30e+000.516
4134MAP4HTA11_3410_2000001011HumanColorectumAD8.00e-09-3.33e-010.0155
4134MAP4HTA11_347_2000001011HumanColorectumAD2.18e-054.60e-01-0.1954
4134MAP4HTA11_1391_2000001011HumanColorectumAD1.43e-035.48e-01-0.059
4134MAP4HTA11_99999970781_79442HumanColorectumMSS1.24e-02-3.16e-010.294
4134MAP4A015-C-203HumanColorectumFAP1.43e-28-3.57e-01-0.1294
4134MAP4A015-C-204HumanColorectumFAP6.55e-05-1.79e-01-0.0228
4134MAP4A014-C-040HumanColorectumFAP2.73e-06-5.65e-01-0.1184
4134MAP4A002-C-201HumanColorectumFAP1.04e-14-3.73e-010.0324
4134MAP4A002-C-203HumanColorectumFAP1.95e-03-1.86e-010.2786
4134MAP4A001-C-119HumanColorectumFAP1.77e-07-3.37e-01-0.1557
4134MAP4A001-C-108HumanColorectumFAP4.48e-16-1.28e-01-0.0272
4134MAP4A002-C-205HumanColorectumFAP5.31e-27-4.12e-01-0.1236
4134MAP4A015-C-005HumanColorectumFAP2.03e-03-2.27e-01-0.0336
4134MAP4A015-C-006HumanColorectumFAP5.96e-20-3.09e-01-0.0994
4134MAP4A015-C-106HumanColorectumFAP2.39e-09-1.58e-01-0.0511
4134MAP4A002-C-114HumanColorectumFAP2.71e-19-2.34e-01-0.1561
4134MAP4A015-C-104HumanColorectumFAP3.28e-32-3.96e-01-0.1899
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003428420Oral cavityOSCCresponse to monosaccharide114/7305225/187232.37e-041.54e-03114
GO:007133316Oral cavityOSCCcellular response to glucose stimulus79/7305151/187235.97e-043.39e-0379
GO:000974619Oral cavityOSCCresponse to hexose109/7305219/187237.41e-044.05e-03109
GO:000167816Oral cavityOSCCcellular glucose homeostasis88/7305172/187237.74e-044.22e-0388
GO:004308710Oral cavityOSCCregulation of GTPase activity165/7305348/187237.94e-044.27e-03165
GO:007133116Oral cavityOSCCcellular response to hexose stimulus79/7305153/187239.92e-045.17e-0379
GO:00071629Oral cavityOSCCnegative regulation of cell adhesion145/7305303/187239.95e-045.18e-03145
GO:000930610Oral cavityOSCCprotein secretion169/7305359/187231.04e-035.34e-03169
GO:000974917Oral cavityOSCCresponse to glucose105/7305212/187231.13e-035.78e-03105
GO:004259316Oral cavityOSCCglucose homeostasis125/7305258/187231.21e-036.08e-03125
GO:003559210Oral cavityOSCCestablishment of protein localization to extracellular region169/7305360/187231.21e-036.08e-03169
GO:007132616Oral cavityOSCCcellular response to monosaccharide stimulus79/7305154/187231.27e-036.33e-0379
GO:19021161Oral cavityOSCCnegative regulation of organelle assembly26/730541/187231.34e-036.62e-0326
GO:00611792Oral cavityOSCCnegative regulation of insulin secretion involved in cellular response to glucose stimulus9/730510/187231.36e-036.62e-039
GO:00716929Oral cavityOSCCprotein localization to extracellular region172/7305368/187231.40e-036.79e-03172
GO:003350016Oral cavityOSCCcarbohydrate homeostasis125/7305259/187231.44e-036.97e-03125
GO:00611788Oral cavityOSCCregulation of insulin secretion involved in cellular response to glucose stimulus37/730564/187231.76e-038.31e-0337
GO:00311023Oral cavityOSCCneuron projection regeneration35/730560/187231.87e-038.82e-0335
GO:001063418Oral cavityOSCCpositive regulation of epithelial cell migration88/7305176/187231.91e-038.94e-0388
GO:007132217Oral cavityOSCCcellular response to carbohydrate stimulus82/7305163/187232.14e-039.81e-0382
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MAP4SNVMissense_Mutationnovelc.3131A>Gp.Asn1044Serp.N1044SP27816protein_codingdeleterious(0.01)possibly_damaging(0.641)TCGA-AR-A5QQ-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycarboplatinPD
MAP4SNVMissense_Mutationc.71A>Gp.Asp24Glyp.D24GP27816protein_codingdeleterious(0)probably_damaging(0.997)TCGA-C8-A26Y-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MAP4insertionIn_Frame_Insnovelc.3410_3411insCTTACTGTCCAAAACTACAAGGACAGTGACAGTTCTGACAGGp.Gln1137delinsHisLeuLeuSerLysThrThrArgThrValThrValLeuThrGlyp.Q1137delinsHLLSKTTRTVTVLTGP27816protein_codingTCGA-A8-A0A2-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
MAP4insertionNonsense_Mutationnovelc.2692_2693insACTGCATATAGTGATGGAGAAAGATCACAGTp.Pro898HisfsTer4p.P898Hfs*4P27816protein_codingTCGA-BH-A0EE-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydocetaxelSD
MAP4SNVMissense_Mutationnovelc.1241N>Tp.Ser414Leup.S414LP27816protein_codingdeleterious(0)possibly_damaging(0.656)TCGA-DS-A5RQ-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinCR
MAP4SNVMissense_Mutationnovelc.2122N>Gp.Gln708Glup.Q708EP27816protein_codingdeleterious(0.04)benign(0.328)TCGA-EK-A2RJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
MAP4SNVMissense_Mutationc.3155G>Ap.Gly1052Glup.G1052EP27816protein_codingdeleterious(0)probably_damaging(0.973)TCGA-EK-A2RK-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
MAP4SNVMissense_Mutationc.2968G>Tp.Gly990Trpp.G990WP27816protein_codingdeleterious(0)probably_damaging(0.999)TCGA-MU-A5YI-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
MAP4SNVMissense_Mutationnovelc.2544G>Cp.Lys848Asnp.K848NP27816protein_codingdeleterious(0)probably_damaging(0.928)TCGA-VS-A94X-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
MAP4SNVMissense_Mutationnovelc.478G>Tp.Ala160Serp.A160SP27816protein_codingtolerated(0.13)benign(0.039)TCGA-5M-AATE-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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