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Gene: INS |
Gene summary for INS |
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Gene information | Species | Human | Gene symbol | INS | Gene ID | 3630 |
Gene name | insulin | |
Gene Alias | IDDM | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | I3WAC9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3630 | INS | HTA12-15-2 | Human | Pancreas | PDAC | 4.21e-07 | 6.33e-01 | 0.2315 |
3630 | INS | HTA12-16-5 | Human | Pancreas | PDAC | 1.34e-09 | 5.46e-01 | 0.047 |
3630 | INS | HTA12-29-1 | Human | Pancreas | PDAC | 1.10e-17 | 5.45e-01 | 0.3722 |
3630 | INS | HTA12-9-1 | Human | Pancreas | PDAC | 1.54e-02 | 3.32e-01 | 0.1532 |
3630 | INS | HTA12-9-2 | Human | Pancreas | PDAC | 3.02e-06 | -8.82e-01 | 0.0835 |
3630 | INS | 3829-EC | Human | Pancreas | PanIN | 3.51e-44 | 7.24e-01 | 0.009 |
3630 | INS | 4347-EC | Human | Pancreas | PanIN | 4.13e-187 | 1.20e+00 | 0.0572 |
3630 | INS | 4741-EC1 | Human | Pancreas | PanIN | 1.43e-45 | 8.66e-01 | 0.0223 |
3630 | INS | 181429 | Human | Pancreas | PDAC | 1.38e-04 | -1.64e+00 | 0.1416 |
3630 | INS | DS20191261Tumor | Human | Pancreas | PDAC | 1.19e-32 | -1.64e+00 | 0.1367 |
3630 | INS | DS20191261TumorKeller | Human | Pancreas | PDAC | 1.12e-06 | -1.64e+00 | 0.1407 |
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Tissue | Expression Dynamics | Abbreviation |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00067574 | Colorectum | FAP | ATP generation from ADP | 32/2622 | 82/18723 | 1.82e-08 | 1.87e-06 | 32 |
GO:00091354 | Colorectum | FAP | purine nucleoside diphosphate metabolic process | 37/2622 | 103/18723 | 2.00e-08 | 1.98e-06 | 37 |
GO:00091794 | Colorectum | FAP | purine ribonucleoside diphosphate metabolic process | 37/2622 | 103/18723 | 2.00e-08 | 1.98e-06 | 37 |
GO:19016533 | Colorectum | FAP | cellular response to peptide | 89/2622 | 359/18723 | 2.93e-08 | 2.64e-06 | 89 |
GO:00091854 | Colorectum | FAP | ribonucleoside diphosphate metabolic process | 37/2622 | 106/18723 | 4.79e-08 | 3.86e-06 | 37 |
GO:00713753 | Colorectum | FAP | cellular response to peptide hormone stimulus | 75/2622 | 290/18723 | 5.60e-08 | 4.29e-06 | 75 |
GO:00328683 | Colorectum | FAP | response to insulin | 68/2622 | 264/18723 | 2.71e-07 | 1.55e-05 | 68 |
GO:00459273 | Colorectum | FAP | positive regulation of growth | 66/2622 | 259/18723 | 6.11e-07 | 3.05e-05 | 66 |
GO:00469394 | Colorectum | FAP | nucleotide phosphorylation | 33/2622 | 101/18723 | 1.40e-06 | 6.17e-05 | 33 |
GO:00068982 | Colorectum | FAP | receptor-mediated endocytosis | 62/2622 | 244/18723 | 1.47e-06 | 6.39e-05 | 62 |
GO:00328693 | Colorectum | FAP | cellular response to insulin stimulus | 54/2622 | 203/18723 | 1.54e-06 | 6.59e-05 | 54 |
GO:01060273 | Colorectum | FAP | neuron projection organization | 31/2622 | 93/18723 | 1.79e-06 | 7.35e-05 | 31 |
GO:00160523 | Colorectum | FAP | carbohydrate catabolic process | 44/2622 | 154/18723 | 1.82e-06 | 7.42e-05 | 44 |
GO:00061654 | Colorectum | FAP | nucleoside diphosphate phosphorylation | 32/2622 | 99/18723 | 2.61e-06 | 9.94e-05 | 32 |
GO:00431122 | Colorectum | FAP | receptor metabolic process | 46/2622 | 166/18723 | 2.70e-06 | 1.02e-04 | 46 |
GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
GO:00091174 | Colorectum | FAP | nucleotide metabolic process | 105/2622 | 489/18723 | 3.52e-06 | 1.25e-04 | 105 |
GO:00091324 | Colorectum | FAP | nucleoside diphosphate metabolic process | 37/2622 | 124/18723 | 3.86e-06 | 1.32e-04 | 37 |
GO:00486392 | Colorectum | FAP | positive regulation of developmental growth | 47/2622 | 174/18723 | 4.55e-06 | 1.52e-04 | 47 |
GO:00067534 | Colorectum | FAP | nucleoside phosphate metabolic process | 105/2622 | 497/18723 | 7.47e-06 | 2.25e-04 | 105 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Breast | ADJ |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Breast | Healthy |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Breast | IDC |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Breast | Precancer |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Cervix | ADJ |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Cervix | Healthy |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Cervix | Precancer |
NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | ADJ |
NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | CRC |
NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | FAP |
NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | Healthy |
NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | MSI-H |
NAMPT | INSR | NAMPT_INSR | VISFATIN | CRC | MSS |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Endometrium | ADJ |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Endometrium | AEH |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Endometrium | EEC |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Endometrium | Healthy |
NAMPT | INSR | NAMPT_INSR | VISFATIN | Esophagus | ESCC |
NAMPT | INSR | NAMPT_INSR | VISFATIN | GC | ADJ |
NAMPT | INSR | NAMPT_INSR | VISFATIN | GC | GC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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